Title:
6,6 SOUTHWESTERN CORE COMPOUNDS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2024/059216
Kind Code:
A3
Abstract:
Negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions.
Inventors:
LINDSLEY CRAIG W (US)
CONN P JEFFREY (US)
FELTS ANDREW S (US)
CAPSTICK RORY A (US)
TEMPLE KAYLA J (US)
RINGUETTE ANNA E (US)
CONN P JEFFREY (US)
FELTS ANDREW S (US)
CAPSTICK RORY A (US)
TEMPLE KAYLA J (US)
RINGUETTE ANNA E (US)
Application Number:
PCT/US2023/032772
Publication Date:
April 25, 2024
Filing Date:
September 14, 2023
Export Citation:
Assignee:
UNIV VANDERBILT (US)
International Classes:
C07D215/48; C07D401/14; C07D403/12; C07D471/04; A61K31/4709; A61P25/00; A61P25/28
Attorney, Agent or Firm:
MYERS JR., Richard S. et al. (US)
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