Title:
7-HETEROCYCLYL QUINOLINE AND THIENO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE
Document Type and Number:
WIPO Patent Application WO2002048112
Kind Code:
A3
Abstract:
The present invention is directed to novel 7-heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives of the general formula (I) or (II), wherein all variables are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions associated with gonadotropin releasing hormone (GnRH). The compounds of the invention are antagonists of GnRH, useful in the treatment of the infertility, prostate cancer, benign prostate hyperplasia (BPH) and as contraceptives.
Inventors:
SUI ZHIHUA
MACIELAG MARK
LANTER JAMES C
MACIELAG MARK
LANTER JAMES C
Application Number:
PCT/US2001/048119
Publication Date:
August 22, 2002
Filing Date:
December 11, 2001
Export Citation:
Assignee:
ORTHO MCNEIL PHARM INC (US)
International Classes:
C07D215/22; A61K31/4365; A61K31/437; A61K31/4709; A61K31/4745; A61P13/08; A61P15/00; A61P15/08; A61P15/16; A61P35/00; A61P43/00; C07D405/04; C07D409/04; C07D471/04; C07D495/04; C07D495/14; (IPC1-7): C07D215/22; C07D471/04; C07D495/04; A61K31/47; A61K31/435; A61P15/00; A61P35/00
Domestic Patent References:
| WO1997014682A1 | 1997-04-24 | |||
| WO1995028405A1 | 1995-10-26 |
Foreign References:
| US6015789A | 2000-01-18 |
Other References:
See also references of EP 1345907A2
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