7-PHENYL-SUBSTITUTED TETRACYCLINE COMPOUNDS

Title:

7-PHENYL-SUBSTITUTED TETRACYCLINE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO2001098236

Kind Code:

A3

Abstract:

7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. 7-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.

Inventors:

NELSON MARK
ISMAIL MOHAMED Y

Application Number:

PCT/US2001/019286

Publication Date:

March 28, 2002

Filing Date:

June 15, 2001

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Assignee:

TUFTS COLLEGE (US)

International Classes:

A61K31/65; C07C237/26; (IPC1-7): C07C237/26; A61K31/65; A61P31/04; C07C231/12

Domestic Patent References:

WO2001019784A1

2001-03-22

Foreign References:

FR2208885A1

1974-06-28

Other References:

KOZA D J: "SYNTHESIS OF 7-SUBSTITUTED TETRACYCLINE DERIVATIVES", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 2, no. 6, 2000, pages 815 - 817, XP000943852, ISSN: 1523-7060

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