Title:
7-POLYAMINOALKYL(OXY)IMINOMETHYLCAMPTOTHECINS BEARING PROTECTIVE GROUPS
Document Type and Number:
WIPO Patent Application WO2005005431
Kind Code:
A3
Abstract:
Compounds are disclosed with the general formula (I) in which the groups are as defined in the description here below and characterized by the presence of polyamine substituents on the imine/oxime residue, such amine groups being in turn protected by suitable protective groups. Said compounds are endowed with potent topoisomerase I inhibiting activity and therefore are useful as medicaments for the treatment of tumours and viral and parasite infections.
Inventors:
GIANNINI GIUSEPPE (IT)
PENCO SERGIO (IT)
TINTI MARIA ORNELLA (IT)
PISANO CLAUDIO (IT)
VESCI LOREDANA (IT)
MERLINI LUCIO (IT)
ZUNINO FRANCO (IT)
PENCO SERGIO (IT)
TINTI MARIA ORNELLA (IT)
PISANO CLAUDIO (IT)
VESCI LOREDANA (IT)
MERLINI LUCIO (IT)
ZUNINO FRANCO (IT)
Application Number:
PCT/IT2004/000374
Publication Date:
February 24, 2005
Filing Date:
July 06, 2004
Export Citation:
Assignee:
SIGMA TAU IND FARMACEUTI (IT)
IST NAZ STUD CURA DEI TUMORI (IT)
GIANNINI GIUSEPPE (IT)
PENCO SERGIO (IT)
TINTI MARIA ORNELLA (IT)
PISANO CLAUDIO (IT)
VESCI LOREDANA (IT)
MERLINI LUCIO (IT)
ZUNINO FRANCO (IT)
IST NAZ STUD CURA DEI TUMORI (IT)
GIANNINI GIUSEPPE (IT)
PENCO SERGIO (IT)
TINTI MARIA ORNELLA (IT)
PISANO CLAUDIO (IT)
VESCI LOREDANA (IT)
MERLINI LUCIO (IT)
ZUNINO FRANCO (IT)
International Classes:
A61K31/437; A61P35/00; C07D491/00; C07D491/22; (IPC1-7): C07D491/22; A61K31/437; A61P35/00
Domestic Patent References:
| WO2004083214A1 | 2004-09-30 | |||
| WO2003101995A2 | 2003-12-11 | |||
| WO1997000876A1 | 1997-01-09 |
Foreign References:
| EP1044977A1 | 2000-10-18 | |||
| US20010008939A1 | 2001-07-19 |
Other References:
S. DALLAVALLE ET AL.: "Novel Cytotoxic 7-Iminomethyl and 7-Aminomethyl Derivatives of Camptothecin", BIOORG. MED. CHEM. LETT., vol. 11, 2001, pages 291 - 294, XP002286415
S. DALLAVALLE ET AL.: "Perspectives in camptothecin development", EXPERT. OPIN. THER. PATENTS, vol. 12, no. 6, 2002, pages 837 - 844, XP002251117
S. DALLAVALLE ET AL.: "Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity", J. MED. CHEM., vol. 44, no. 20, 9 May 2001 (2001-05-09), pages 3264 - 3274, XP002307863
S. DALLAVALLE ET AL.: "Perspectives in camptothecin development", EXPERT. OPIN. THER. PATENTS, vol. 12, no. 6, 2002, pages 837 - 844, XP002251117
S. DALLAVALLE ET AL.: "Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity", J. MED. CHEM., vol. 44, no. 20, 9 May 2001 (2001-05-09), pages 3264 - 3274, XP002307863
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