Title:
7H-AZULENE[1,2,3-I,J]ISOQUINOLIN-7-ONE COMPOUNDS, SINGLE CRYSTAL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/171684
Kind Code:
A1
Abstract:
Provided in the present invention are a class of 7H-azulene[1,2,3-i,j]isoquinolin-7-one compounds, a single crystal and a use thereof: a 7H-azulene[1,2,3-i,j]isoquinolin-7-one compound has a structure represented by formula (I), and the same obtains a crude extract by means Acorus calamus L. extraction, then being isolated by means of sequential extraction using solvents of different polarities and column chromatography to obtain a new alkaloid compound. The present invention is expected to be developed into a new class of drugs which attains the goals of preventing and treating diseases such as Alzheimer's disease, cerebral stroke and epilepsy by means of exerting a nerve cell protection effect.
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Inventors:
LI SHUNXIANG (CN)
LI JUAN (CN)
LI JUAN (CN)
Application Number:
PCT/CN2018/080074
Publication Date:
September 27, 2018
Filing Date:
March 22, 2018
Export Citation:
Assignee:
UNIV HUNAN CHINESE MEDICINE (CN)
International Classes:
A61K31/4738; C07D221/18; A61K31/4741; A61P9/10; A61P25/00; A61P25/08; A61P25/28; C07D491/056
Foreign References:
| CN1220260A | 1999-06-23 | |||
| CN1973877A | 2007-06-06 | |||
| CN104211640A | 2014-12-17 |
Other References:
LI, JUAN ET AL.: "A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus Calamus L.", CHEMISTRY & BIODIVERSITY, vol. 14, no. 10, October 2017 (2017-10-01), XP055540629, ISSN: 1612-1872
Attorney, Agent or Firm:
CHANGSHA CHUWEI INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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