Title:
AAK1 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/284838
Kind Code:
A1
Abstract:
A compound of formula (I) and a stereoisomer, deuterated compound, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, or a pharmaceutical composition containing same, and the use thereof as an AAK1 inhibitor in the preparation of a drug for treating related diseases.
Inventors:
LI YAO (CN)
WANG WENJING (CN)
SHI ZONGJUN (CN)
ZHANG HAOLIANG (CN)
DU CHENGLONG (CN)
CHENG FENGKAI (CN)
LIU XIN (CN)
ZHANG XIAOZHUAN (CN)
WANG LONG (CN)
TANG PINGMING (CN)
YU YAN (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
WANG WENJING (CN)
SHI ZONGJUN (CN)
ZHANG HAOLIANG (CN)
DU CHENGLONG (CN)
CHENG FENGKAI (CN)
LIU XIN (CN)
ZHANG XIAOZHUAN (CN)
WANG LONG (CN)
TANG PINGMING (CN)
YU YAN (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2022/105793
Publication Date:
January 19, 2023
Filing Date:
July 14, 2022
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/04; A61K31/444; A61P25/00
Domestic Patent References:
| WO2010038465A1 | 2010-04-08 | |||
| WO2017059085A1 | 2017-04-06 |
Foreign References:
| CN108368084A | 2018-08-03 | |||
| CN108290843A | 2018-07-17 | |||
| CN106458994A | 2017-02-22 |
Other References:
HENDERSONCONNER, MOL. BIOL. CELL, vol. 18, 2007, pages 2698 - 2706
CONNER ET AL., TRAFFIC, vol. 4, 2003, pages 885 - 890
JACKSON ET AL., J. CELL. BIOL., vol. 163, 2003, pages 231 - 236
RICOTTA ET AL., J. CELL BIO., vol. 156, 2002, pages 791 - 795
CONNERSCHMID, J. CELL BIO, vol. 156, 2002, pages 921 - 929
MOTELY ET AL., MOL. BIOL. CELL, vol. 17, 2006, pages 5298 - 5308
KUAI ET AL., CHEMISTRY AND BIOLOGY, vol. 18, 2011, pages 891 - 906
BUONANNO, BRAIN RES. BULL., vol. 83, 2010, pages 122 - 131
GREENWOOD ET AL., AM. J. PSYCHIATRY, vol. 168, 2011, pages 930 - 946
JAARO-PELED ET AL., SCHIZOPHRENIA BULLETIN, vol. 36, 2010, pages 301 - 313
WEN ET AL., PROC. NATL. ACAD. SCI. USA., vol. 107, 2010, pages 1211 - 1216
LATOURELLE ET AL., BMC MED. GENET., vol. 10, 2009, pages 98
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN, INC.
T. L. GILCHRIST: "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 1992, WILEY-INTERSCIENCE
FUHRHOP, JPENZLIN G: "Organic Synthesis: Concepts, Methods, Starting Materials", 1994, JOHN WILEY & SONS
HOFFMAN, R.V.: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia", vol. 8, 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", vol. 55, 1942, JOHN WILEY & SONS
P. H. STAHLC. G. WERMUTH: "Handbook of Pharmaceutical Salts", vol. 73, 2002, VERLAG HELVETICA CHIMICA ACTA
no. 1310584-14-5
CONNER ET AL., TRAFFIC, vol. 4, 2003, pages 885 - 890
JACKSON ET AL., J. CELL. BIOL., vol. 163, 2003, pages 231 - 236
RICOTTA ET AL., J. CELL BIO., vol. 156, 2002, pages 791 - 795
CONNERSCHMID, J. CELL BIO, vol. 156, 2002, pages 921 - 929
MOTELY ET AL., MOL. BIOL. CELL, vol. 17, 2006, pages 5298 - 5308
KUAI ET AL., CHEMISTRY AND BIOLOGY, vol. 18, 2011, pages 891 - 906
BUONANNO, BRAIN RES. BULL., vol. 83, 2010, pages 122 - 131
GREENWOOD ET AL., AM. J. PSYCHIATRY, vol. 168, 2011, pages 930 - 946
JAARO-PELED ET AL., SCHIZOPHRENIA BULLETIN, vol. 36, 2010, pages 301 - 313
WEN ET AL., PROC. NATL. ACAD. SCI. USA., vol. 107, 2010, pages 1211 - 1216
LATOURELLE ET AL., BMC MED. GENET., vol. 10, 2009, pages 98
S. R. SANDLER ET AL.: "Organic Functional Group Preparations", 1983, JOHN WILEY & SONS
H. O. HOUSE: "Modern Synthetic Reactions", 1972, W. A. BENJAMIN, INC.
T. L. GILCHRIST: "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure", 1992, WILEY-INTERSCIENCE
FUHRHOP, JPENZLIN G: "Organic Synthesis: Concepts, Methods, Starting Materials", 1994, JOHN WILEY & SONS
HOFFMAN, R.V.: "Organic Chemistry, An Intermediate Text", 1996, OXFORD UNIVERSITY PRESS
LAROCK, R. C: "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia", vol. 8, 1999, JOHN WILEY & SONS
SOLOMONS, T. W. G: "Modern Carbonyl Chemistry", 2000, JOHN WILEY & SONS
STOWELL, J.C.: "Intermediate Organic Chemistry", 1993, WILEY-INTERSCIENCE
"Organic Reactions", vol. 55, 1942, JOHN WILEY & SONS
P. H. STAHLC. G. WERMUTH: "Handbook of Pharmaceutical Salts", vol. 73, 2002, VERLAG HELVETICA CHIMICA ACTA
no. 1310584-14-5
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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