Title:
ABCA-1 ELEVATING COMPOUNDS AGAINST CORONARY ARTERY DISEASE OR ATHEROSCLEROSIS
Document Type and Number:
WIPO Patent Application WO2002046181
Kind Code:
A3
Abstract:
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
Inventors:
CAMPBELL MICHAEL
IBRAHIM PRABHA N
ZABLOCKI JEFF A
LAWN RICHARD
IBRAHIM PRABHA N
ZABLOCKI JEFF A
LAWN RICHARD
Application Number:
PCT/US2001/046979
Publication Date:
December 27, 2002
Filing Date:
December 06, 2001
Export Citation:
Assignee:
CV THERAPEUTICS INC (US)
International Classes:
A61K31/085; A61K31/136; A61K31/16; A61K31/165; A61K31/167; A61K45/00; A61K31/17; A61K31/18; A61K31/357; A61K31/435; A61K31/47; A61K31/472; A61K31/495; A61K31/505; A61K31/506; A61K31/53; A61K45/06; A61P3/06; A61P9/00; A61P9/10; A61P43/00; C07C237/04; C07C237/06; C07C237/22; C07C237/40; C07C275/26; C07C311/20; C07C323/36; C07C323/40; C07C323/60; C07C327/42; C07C327/44; C07C327/48; C07C335/16; C07D215/38; C07D217/24; C07D239/48; C07D251/16; C07D251/22; C07D251/52; C07D319/08; C07D319/18; C07D401/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D413/14; (IPC1-7): C07D319/08; C07C237/40; A61K31/357; A61K31/167; A61P9/10
Domestic Patent References:
| WO2000027820A1 | 2000-05-18 | |||
| WO2000027819A2 | 2000-05-18 | |||
| WO1999041239A1 | 1999-08-19 | |||
| WO2000005201A1 | 2000-02-03 |
Foreign References:
| EP0636619A1 | 1995-02-01 | |||
| US4971957A | 1990-11-20 | |||
| US5776951A | 1998-07-07 | |||
| US6008230A | 1999-12-28 | |||
| EP0718285A2 | 1996-06-26 |
Other References:
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199657
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199658
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199659
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199660
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199661
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199658
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199659
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199660
DATABASE CROSSFIRE BEILSTEIN Beilstein Institut zur Foerderung der Wissenschaften, Frankfurt am Main, DE; XP002199661
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