Title:
ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPEUTIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME
Document Type and Number:
WIPO Patent Application WO/2012/143624
Kind Code:
A3
Abstract:
The invention relates to acadesine derivatives as a drug, as well as to said derivatives for the treatment of cancer and particularly for the treatment of chronic myeloid leukemia (CML). The invention further relates to a product containing said derivatives and at least one second active ingredient as a combination product to be simultaneously or separately administered, or administered over time, in the treatment of cancer, as well as to a pharmaceutical composition including said derivatives and a pharmaceutically acceptable carrier. Finally, the invention relates to a method for the in vitro inhibition of the proliferation of cells, including contacting a cell with said derivatives in vitro, and to methods for synthesizing said derivatives.
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Inventors:
BENHIDA RACHID (FR)
AUBERGER PATRICK (FR)
MALNUIT VINCENT (FR)
DRIOWYA MOHSINE (FR)
PUISSANT ALEXANDRE (FR)
ROBERT GUILLAUME (FR)
AUBERGER PATRICK (FR)
MALNUIT VINCENT (FR)
DRIOWYA MOHSINE (FR)
PUISSANT ALEXANDRE (FR)
ROBERT GUILLAUME (FR)
Application Number:
PCT/FR2012/000147
Publication Date:
December 20, 2012
Filing Date:
April 17, 2012
Export Citation:
Assignee:
UNIV NICE SOPHIA ANTIPOLIS (FR)
CENTRE NAT RECH SCIENT (FR)
INST NAT SANTE RECH MED (FR)
BENHIDA RACHID (FR)
AUBERGER PATRICK (FR)
MALNUIT VINCENT (FR)
DRIOWYA MOHSINE (FR)
PUISSANT ALEXANDRE (FR)
ROBERT GUILLAUME (FR)
CENTRE NAT RECH SCIENT (FR)
INST NAT SANTE RECH MED (FR)
BENHIDA RACHID (FR)
AUBERGER PATRICK (FR)
MALNUIT VINCENT (FR)
DRIOWYA MOHSINE (FR)
PUISSANT ALEXANDRE (FR)
ROBERT GUILLAUME (FR)
International Classes:
A61K31/4192; A61K31/7056; A61P35/02; C07D249/06; C07H19/056
Domestic Patent References:
| WO2009060053A1 | 2009-05-14 | |||
| WO2004022572A1 | 2004-03-18 |
Other References:
VINCENT MALNUIT ET AL: "Tandem Azide-Alkyne 1,3-Dipolar Cycloaddition/Electrophilic Addition: A Concise Three-Component Route to 4,5-Disubstituted Triazolyl-Nucleosides", SYNLETT, vol. 2009, no. 13, 1 August 2009 (2009-08-01), pages 2123 - 2126, XP055012231, ISSN: 0936-5214, DOI: 10.1055/s-0029-1217560
GUILLAUME ROBERT ET AL: "Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death", PLOS ONE, vol. 4, no. 11, 1 January 2009 (2009-01-01), pages E7889, XP055012425, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0007889
GUILLAUME ROBERT ET AL: "Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death", PLOS ONE, vol. 4, no. 11, 1 January 2009 (2009-01-01), pages E7889, XP055012425, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0007889
Attorney, Agent or Firm:
MACQUET, Christophe (Arche des Dolines, rue Soutrane Sophia Antipolis, FR)
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