Title:
ACE2-FC FUSION PROTEINS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/234160
Kind Code:
A3
Abstract:
The present invention relates to fusion proteins of ACE2 with IgG Fc and the medical use of these fusion proteins, in particular in the prevention or treatment of infections with coronaviruses such as SARS-CoV-2.
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Inventors:
REITER ALWIN (DE)
BROCKMEYER CARSTEN (DE)
WOLSCHIN FLORIAN (DE)
BROCKMEYER CARSTEN (DE)
WOLSCHIN FLORIAN (DE)
Application Number:
PCT/EP2021/063692
Publication Date:
January 13, 2022
Filing Date:
May 21, 2021
Export Citation:
Assignee:
FORMYCON AG (DE)
International Classes:
A61P31/14; A61K38/48; A61P9/12; A61P11/00; A61P13/12; C12N9/48
Domestic Patent References:
| WO2006122819A1 | 2006-11-23 | |||
| WO2020086758A1 | 2020-04-30 | |||
| WO2011066501A1 | 2011-06-03 | |||
| WO2021170113A1 | 2021-09-02 | |||
| WO2021168305A1 | 2021-08-26 |
Other References:
ROBERT L. KRUSE: "Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China", F1000RESEARCH, vol. 9, 31 January 2020 (2020-01-31) - 7 February 2020 (2020-02-07), GB, pages 72, XP055737402, ISSN: 2046-1402, DOI: 10.12688/f1000research.22211.2
CHANGHAI LEI ET AL: "Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig", NATURE COMMUNICATIONS, 24 April 2020 (2020-04-24), England, pages 2070 - 2070, XP055745525, Retrieved from the Internet DOI: 10.1038/s41467-020-16048-4
CHANGHAI LEI ET AL: "Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig", 2 February 2020 (2020-02-02), XP055745522, Retrieved from the Internet DOI: 10.1101/2020.02.01.929976
MICHAEL J. MOORE ET AL: "Retroviruses Pseudotyped with the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Efficiently Infect Cells Expressing Angiotensin-Converting Enzyme 2", JOURNAL OF VIROLOGY, vol. 78, no. 19, 14 September 2004 (2004-09-14), US, pages 10628 - 10635, XP055745721, ISSN: 0022-538X, DOI: 10.1128/JVI.78.19.10628-10635.2004
HONG PENG JIA ET AL: "Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 297, no. 1, 1 July 2009 (2009-07-01), US, pages 84 - 96, XP055745863, ISSN: 1040-0605, DOI: 10.1152/ajplung.00071.2009
A. HEURICH ET AL: "TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein", JOURNAL OF VIROLOGY, vol. 88, no. 2, 13 November 2013 (2013-11-13), US, pages 1293 - 1307, XP055731964, ISSN: 0022-538X, DOI: 10.1128/JVI.02202-13
ZON W. LAI ET AL: "Angiotensin-Converting Enzyme 2 Ectodomain Shedding Cleavage-Site Identification: Determinants and Constraints", BIOCHEMISTRY, vol. 50, no. 23, 12 May 2011 (2011-05-12), pages 5182 - 5194, XP055745872, ISSN: 0006-2960, DOI: 10.1021/bi200525y
CHANGHAI LEI ET AL: "Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig", NATURE COMMUNICATIONS, 24 April 2020 (2020-04-24), England, pages 2070 - 2070, XP055745525, Retrieved from the Internet
CHANGHAI LEI ET AL: "Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig", 2 February 2020 (2020-02-02), XP055745522, Retrieved from the Internet
MICHAEL J. MOORE ET AL: "Retroviruses Pseudotyped with the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Efficiently Infect Cells Expressing Angiotensin-Converting Enzyme 2", JOURNAL OF VIROLOGY, vol. 78, no. 19, 14 September 2004 (2004-09-14), US, pages 10628 - 10635, XP055745721, ISSN: 0022-538X, DOI: 10.1128/JVI.78.19.10628-10635.2004
HONG PENG JIA ET AL: "Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 297, no. 1, 1 July 2009 (2009-07-01), US, pages 84 - 96, XP055745863, ISSN: 1040-0605, DOI: 10.1152/ajplung.00071.2009
A. HEURICH ET AL: "TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein", JOURNAL OF VIROLOGY, vol. 88, no. 2, 13 November 2013 (2013-11-13), US, pages 1293 - 1307, XP055731964, ISSN: 0022-538X, DOI: 10.1128/JVI.02202-13
ZON W. LAI ET AL: "Angiotensin-Converting Enzyme 2 Ectodomain Shedding Cleavage-Site Identification: Determinants and Constraints", BIOCHEMISTRY, vol. 50, no. 23, 12 May 2011 (2011-05-12), pages 5182 - 5194, XP055745872, ISSN: 0006-2960, DOI: 10.1021/bi200525y
Attorney, Agent or Firm:
MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELLSCHAFT MBH (DE)
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