Title:
ACELLULAR DERMAL MATRIX FOR IMPLANTATION IN BODY, USING VEGETABLE COMPLEX NATURAL SURFACTANT, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/136538
Kind Code:
A1
Abstract:
The present invention is a technology relating to: an acellular dermal matrix for implantation in the body, using a vegetable complex natural surfactant; and a preparation method therefor, and, more specifically, to: an acellular dermal matrix for implantation in the body, using a vegetable complex natural surfactant so as to reduce cell remnants and toxic influx and have excellent biocompatibility; and a preparation method therefor. The method for preparing the acellular dermal matrix for implantation in the body, according to the present invention, comprises the steps of: (i) removing the epidermal layer from skin tissue; (ii) treating the skin tissue, from which the epidermal layer has been removed, with a vegetable complex natural surfactant so as to remove cells of the dermal layer, thereby preparing acellular dermis; and (iii) grinding the acellular dermis into particles, thereby preparing a powder form. The method for preparing the acellular dermal matrix for implantation in the body, according to the present invention, allows cells to be removed by using a vegetable complex natural surfactant, and thus cell remnants and toxic influx can be reduced while cell tissue damage is minimized, and, when injected into the body, the acellular dermal matrix for implantation in the body has excellent biocompatibility and exhibits remarkably low inflammatory and immune responses.
Inventors:
LEE HYEONG SUK (KR)
KIM SU DONG (KR)
PARK DONG WOOK (KR)
KIM MI RAN (KR)
KIM JOO HEE (KR)
KIM JOONG HYUN (KR)
KIM SU DONG (KR)
PARK DONG WOOK (KR)
KIM MI RAN (KR)
KIM JOO HEE (KR)
KIM JOONG HYUN (KR)
Application Number:
PCT/KR2023/000140
Publication Date:
July 20, 2023
Filing Date:
January 04, 2023
Export Citation:
Assignee:
ERAETECH KOREA CO LTD (KR)
International Classes:
A61L27/36; A61L27/60
Foreign References:
| KR20150143311A | 2015-12-23 | |||
| JP2015160040A | 2015-09-07 | |||
| KR100469661B1 | 2005-02-02 | |||
| US10322835B1 | 2019-06-18 | |||
| KR102366303B1 | 2022-02-23 |
Other References:
LEE, HYEONG SUK: "A Study on the Manufacturing Method of Cell-Free Collagen Layer Applicable to Tissue Restoration", MASTER'S THESIS, August 2021 (2021-08-01), Korea, pages 1 - 30, XP009548126
Attorney, Agent or Firm:
SEO, Jong Chul (KR)
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