Title:
ACELLULAR SUBSTRATES AND METHODS OF MAKING THE SAME
Document Type and Number:
WIPO Patent Application WO/2023/133124
Kind Code:
A3
Abstract:
Acellular substrates that provide continuous 3D growth of a variety of cells and/or tissues and methods of making the same are provided. The acellular substrates have a three- dimensional (3D) macrostructure defined by a continuous matrix of extracellular matrix (ECM) material associated with a first cell type of interest and a network of microporous channels and/or chambers extending throughout the continuous matrix of ECM material associated with the first cell type of interest. Methods of forming a personalized graft using a patient's own cells is also provided.
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Inventors:
MELLOTT ADAM J (US)
Application Number:
PCT/US2023/010091
Publication Date:
August 31, 2023
Filing Date:
January 04, 2023
Export Citation:
Assignee:
RONAWK LLC (US)
International Classes:
A61L27/36; A61F2/00; A61L27/38; A61L27/34
Foreign References:
| US20160331504A1 | 2016-11-17 | |||
| US20170304507A1 | 2017-10-26 | |||
| US20150037434A1 | 2015-02-05 | |||
| US20200188557A1 | 2020-06-18 |
Other References:
BLACKMON RICHARD L., SANDHU RUPNINDER, CHAPMAN BRIAN S., CASBAS-HERNANDEZ PATRICIA, TRACY JOSEPH B., TROESTER MELISSA A., OLDENBUR: "Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography", BIOPHYSICAL JOURNAL, vol. 110, no. 8, 1 April 2016 (2016-04-01), AMSTERDAM, NL, pages 1858 - 1868, XP093088331, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2016.03.014
Attorney, Agent or Firm:
JOHNSON, III, John E. et al. (US)
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