Title:
ACID-MODIFIED ARABINOGALACTAN PROTEIN COMPOSITION
Document Type and Number:
WIPO Patent Application WO2002002607
Kind Code:
A3
Abstract:
An acid-modified arabinogalactan protein composition, having an arabinose-galactose ratio of less than 3.5:1 or less than 80 % of the arabinose:galactose ratio of the arabinogalactan protein component of the composition prior to acid modification, prepared from Astragalus membranaceus, especially from the roots of Atragalus membranaceus, is capable of reconstitution into an aqueous intravenously injectable formulation; and is useful for stimulating hematopoiesis, inducing the proliferation or maturation of megakaryocytes, stimulating the production of IL-1 beta , Il-6, TNF- alpha , IFN- gamma , GM-CSF, or G-CSF, stimulating the production or action of neutrophils, treating neutropenia, anemia, or thrombocytopenia, accelerating recovery from exposure (e.g. accidental or non-therapeutic exposure, as well as therapeutic exposure) to cytotoxic agents or radiation, treating cachexia, emesis, or drug withdrawal symptoms, or modifying biological responses or protecting hepatic cells in hepatitis B, in a mammal when intravenously administered to the mammal.
Inventors:
AN JINHUA (US)
LEU KAREN S (US)
LENNOX EDWIN S (US)
MUSSER JOHN H (US)
LEU KAREN S (US)
LENNOX EDWIN S (US)
MUSSER JOHN H (US)
Application Number:
PCT/US2001/020828
Publication Date:
January 23, 2003
Filing Date:
June 28, 2001
Export Citation:
Assignee:
PHARMAGENESIS INC (US)
AN JINHUA (US)
LEU KAREN S (US)
LENNOX EDWIN S (US)
MUSSER JOHN H (US)
AN JINHUA (US)
LEU KAREN S (US)
LENNOX EDWIN S (US)
MUSSER JOHN H (US)
International Classes:
A61K9/08; A61K31/715; A61K36/00; A61K36/48; A61K36/481; A61K38/00; A61K38/18; A61K38/19; A61K38/20; A61K38/22; A61K45/00; A61P1/08; A61P1/16; A61P7/00; A61P7/04; A61P7/06; A61P25/30; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P37/04; A61P39/00; A61P43/00; C07K1/12; C07K1/18; C07K14/415; C08B37/00; (IPC1-7): C07K14/415; A61K35/78; A61K38/18; A61K38/19; A61K38/20; A61P31/00; A61P37/00; A61P43/00
Domestic Patent References:
| WO2001000682A1 | 2001-01-04 |
Foreign References:
| EP0441278A1 | 1991-08-14 | |||
| EP0668072A1 | 1995-08-23 | |||
| US5830747A | 1998-11-03 |
Other References:
MCLAUGHLIN M: "IDENTIFICATION OF IMMUNOSTIMULANTS DERIVED FROM THE PLANT ASTRAGALUS MEMBRANECEAUS", DISSERTATION ABSTRACTS INTERNATIONAL, ANN ARBOR, MI, US, vol. 47, no. 7, 1987, pages 2891, XP000942629
CHU DATONG: "IMMUNOSTIMULANT CONTAINING INTERLEUKIN-2 AND SUBSTANCE F3 FROM ASTRAGA", CHEMICAL ABSTRACTS, XP002150924
SOMMER-KNUDSEN J ET AL: "Hydroxyproline-rich plant glycoproteins", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 47, no. 4, February 1998 (1998-02-01), pages 483 - 497, XP004293747, ISSN: 0031-9422
See also references of EP 1294750A2
CHU DATONG: "IMMUNOSTIMULANT CONTAINING INTERLEUKIN-2 AND SUBSTANCE F3 FROM ASTRAGA", CHEMICAL ABSTRACTS, XP002150924
SOMMER-KNUDSEN J ET AL: "Hydroxyproline-rich plant glycoproteins", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 47, no. 4, February 1998 (1998-02-01), pages 483 - 497, XP004293747, ISSN: 0031-9422
See also references of EP 1294750A2
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