Title:
ACRYLAMIDE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2021/117733
Kind Code:
A1
Abstract:
Provided is an acrylamide compound, which is useful for the promotion of platelet production from platelet progenitor cells such as megakaryocytes in vitro and represented by general formula [I]:wherein each symbol is as defined in the description.
Inventors:
HAYASHI HIDEKI (JP)
TAGA RYOSUKE (JP)
SAKAMOTO YUKI (JP)
KUWANO NOZOMI (JP)
MINENO KURUMI (JP)
OHDACHI KAZUHIRO (JP)
FUJIMORI YUSUKE (JP)
TAGA RYOSUKE (JP)
SAKAMOTO YUKI (JP)
KUWANO NOZOMI (JP)
MINENO KURUMI (JP)
OHDACHI KAZUHIRO (JP)
FUJIMORI YUSUKE (JP)
Application Number:
PCT/JP2020/045713
Publication Date:
June 17, 2021
Filing Date:
December 08, 2020
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
C07D209/22; A61K31/405; A61K31/416; A61K31/422; A61K31/427; A61K31/437; A61K31/444; C07D235/06; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D471/04
Domestic Patent References:
| WO2019167973A1 | 2019-09-06 | |||
| WO2014138485A1 | 2014-09-12 | |||
| WO2014138485A1 | 2014-09-12 | |||
| WO2016204256A1 | 2016-12-22 | |||
| WO2010059401A2 | 2010-05-27 | |||
| WO2019167973A1 | 2019-09-06 | |||
| WO2020050409A1 | 2020-03-12 |
Foreign References:
| EP3312270A1 | 2018-04-25 |
Other References:
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S. N. BAYTAS ET. AL.: "Synthesis, biological evolution and molecular docking studies of trans-indole-3-acrylamide derivatives , a new class of tubulin polymerisation inhibitors.", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 22, 20 April 2014 (2014-04-20), pages 3096 - 3104, XP028664746, DOI: 10.1016/j.bmc.2014.04.027
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ITO ET AL., CELL, vol. 174, 2018, pages 636
PERRON ET AL., J. BIOL. CHEM., vol. 293, 2018, pages 8285
"Comprehensive Organic Transformations", 1989, CHEMICAL SOCIETY OF JAPAN
P.G.M. WUTST.W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
SHIGERU OHBASHIGENOBU YANO, BASIC COURSE FOR CHEMISTS 12, X-RAY CRYSTAL STRUCTURE ANALYSIS, 1999
WALDEMAR ADAMRAINER T. FELLCHANTU R.: "Saha-Moller and Cong-Gui Zhao: Tetrahedron: Asymmetry", vol. 9, 1998, pages: 397 - 401
YUANMING ZHUYONG TUHONGWU YUYIAN SHI, TETRAHEDRON LETT., vol. 29, 1988, pages 2437 - 2440
Y. LI ET. AL.: "Design, synthesis and antiproliferative activities of novel benzamide derivatives as HDAC inhibitors.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 100, 5 June 2015 (2015-06-05), pages 270 - 276, XP002801755, DOI: 10.1016/j.ejmech.2015.05.045
S. N. BAYTAS ET. AL.: "Synthesis, biological evolution and molecular docking studies of trans-indole-3-acrylamide derivatives , a new class of tubulin polymerisation inhibitors.", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 22, 20 April 2014 (2014-04-20), pages 3096 - 3104, XP028664746, DOI: 10.1016/j.bmc.2014.04.027
TAKAYAMA ET AL., BLOOD, vol. 111, 2008, pages 5298
BOITANO ET AL., SCIENCE, vol. 329, 2010, pages 1345
STRASSEL ET AL., BLOOD, vol. 127, 2016, pages 2231
ITO ET AL., CELL, vol. 174, 2018, pages 636
PERRON ET AL., J. BIOL. CHEM., vol. 293, 2018, pages 8285
"Comprehensive Organic Transformations", 1989, CHEMICAL SOCIETY OF JAPAN
P.G.M. WUTST.W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
SHIGERU OHBASHIGENOBU YANO, BASIC COURSE FOR CHEMISTS 12, X-RAY CRYSTAL STRUCTURE ANALYSIS, 1999
WALDEMAR ADAMRAINER T. FELLCHANTU R.: "Saha-Moller and Cong-Gui Zhao: Tetrahedron: Asymmetry", vol. 9, 1998, pages: 397 - 401
YUANMING ZHUYONG TUHONGWU YUYIAN SHI, TETRAHEDRON LETT., vol. 29, 1988, pages 2437 - 2440
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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