Title:
ACTIVE PEPTIDE FOR INHIBITING AMPA RECEPTOR AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/004811
Kind Code:
A1
Abstract:
Provided in the application are an active peptide for inhibiting an AMPA receptor and a preparation method and the use thereof. The preparation method for the active peptide comprises the following steps: 1) salmon skin is soaked and then crushed, water is added and same is beaten, and the pH is adjusted to 6.5-7.5; 2) conducting a first enzymolysis by using a neutral protease; 3) conducting a second enzymolysis by using papain and then deactivating enzymes; and 4) enzymatic hydrolysate is centrifuged, and then the supernatant is membrane filtrated, concentrated and decolorized to prepare the active peptide. The active peptide contains a tetrapeptide with an amino-acid sequence of Glu-Gly-Ala-Arg. The tetrapeptide has a good solubility, can selectively inhibit the synaptic transmission of neurons caused by the AMPA receptor, and has an antiepileptic effect.
Inventors:
CAI MUYI (CN)
GU HUAIYU (CN)
LU JUN (CN)
PAN XINGCHANG (CN)
CAI SONG (CN)
MA YONG (CN)
DUAN SONGWEI (CN)
CHEN LIANG (CN)
GU HUAIYU (CN)
LU JUN (CN)
PAN XINGCHANG (CN)
CAI SONG (CN)
MA YONG (CN)
DUAN SONGWEI (CN)
CHEN LIANG (CN)
Application Number:
PCT/CN2015/083571
Publication Date:
January 12, 2017
Filing Date:
July 08, 2015
Export Citation:
Assignee:
CHINA NAT RES INST OF FOOD AND FERMENTATION IND (CN)
International Classes:
C07K1/34; A61P25/08; C07K4/12; C07K5/113
Foreign References:
| CN1781933A | 2006-06-07 | |||
| CN103205480A | 2013-07-17 | |||
| CN104694615A | 2015-06-10 | |||
| CN1738618A | 2006-02-22 | |||
| CN101240312A | 2008-08-13 |
Attorney, Agent or Firm:
LEADER PATENT & TRADEMARK FIRM (CN)
Download PDF: