Title:
ACTIVE POLYPEPTIDE FOR INHIBITING GROWTH OF LIVER CANCER CELLS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/082803
Kind Code:
A1
Abstract:
The present invention relates to an active polypeptide for inhibiting the growth of liver cancer cells, and a preparation method therefor and the use thereof. The amino acid sequence of the active polypeptide is VNNSSLIGLGYTQTLKPGIK. The active polypeptide can target tumor cells, inhibit DNA synthesis of liver cancer cells, inhibit the proliferation and growth thereof, accelerate the repair of liver tissues and recover the liver function. The synthesized active polypeptide can be used for preparing and developing a drug for preventing or treating hepatitis, cirrhosis and hepatic fibrosis.
Inventors:
WANG XIAOMING (CN)
LI SHAN (CN)
ZHANG LEI (CN)
LI SHAN (CN)
ZHANG LEI (CN)
Application Number:
PCT/CN2022/117155
Publication Date:
May 19, 2023
Filing Date:
September 06, 2022
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
ZHONGSHAN INSTITUTE OF MODERN INDUSTRIAL TECHNOLOGY SOUTH (CN)
ZHONGSHAN INSTITUTE OF MODERN INDUSTRIAL TECHNOLOGY SOUTH (CN)
International Classes:
C07K7/08; C07K1/04; C07K1/06; C07K1/16
Domestic Patent References:
| WO2007134328A2 | 2007-11-22 | |||
| WO2019169697A1 | 2019-09-12 |
Foreign References:
| CN113845571A | 2021-12-28 | |||
| US20180372754A1 | 2018-12-27 | |||
| US20120087862A1 | 2012-04-12 |
Other References:
TAISLA SOPRANI;VINICIUS KUFFER ULIANA;ROGERIO FAUSTINO RIBEIRO;SERGIO LISBOA;GABRIELLA XAVIER MARETTO;ANDR? TEIXEIRA SILVA DA FERR: "Cardiac protein changes in rats after soybean oil treatment: a proteomic study", LIPIDS IN HEALTH AND DISEASE, BIOMED CENTRAL, LONDON, GB, vol. 14, no. 1, 14 April 2015 (2015-04-14), GB , pages 26, XP021223026, ISSN: 1476-511X, DOI: 10.1186/s12944-015-0024-3
LEMASTERS, J.J. HOLMUHAMEDOV, E.: "Voltage-dependent anion channel (VDAC) as mitochondrial governator-Thinking outside the box", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., AMSTERDAM, NL, vol. 1762, no. 2, 1 February 2006 (2006-02-01), NL , pages 181 - 190, XP005230503, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2005.10.006
LEMASTERS, J.J. HOLMUHAMEDOV, E.: "Voltage-dependent anion channel (VDAC) as mitochondrial governator-Thinking outside the box", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., AMSTERDAM, NL, vol. 1762, no. 2, 1 February 2006 (2006-02-01), NL , pages 181 - 190, XP005230503, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2005.10.006
Attorney, Agent or Firm:
SHENZHEN TALENT PATENT SERVICE (CN)
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