WHAT IS CLAIMED IS:

1. A compound of formula I

I or a stereoisomer or a tautomer or a pharmaceutically acceptable salt thereof, wherein:

R ¹ is an aryl or heterocyclic ring, which may be optionally substituted with one or more R ¹⁰ 's;

R ² and R ³ are independently:

(a) halo,

(b) (Q-C^-alkoxy optionally substituted with one or more R ^π 's,

(c) (Q-C^-perfluoroalkyl, (d) (d-C^-alkyl-SCOV,

(e) aryl-(CH ₂ ) _r -S(O) _n -,

(f) cyano,

(g) -CO ₂ H,

(h) -CO(C ₁ -C ₆ )-alkyl, (i) -CO^d-C^alkyl,

Q) -CONR ⁸ R ⁹ ,

(k) -0(CO)NR ⁸ R ⁹ ,

(1) -NR ⁸ (CO)NR ⁸ R ⁹ ,

(m) -NR ⁸ R ⁹ , (n) hydrogen,

(o) Q-Cio-alkyl optionally substituted with one or more R ¹ * 's,

(p) (C ₂ -C ₁₀ )-alkenyl optionally substituted with one or more R ¹¹ 's,

(q) (C ₂ -C ₁₀ )-alkynyl optionally substituted with one or more R ¹ * 's,

(r) aryl optionally substituted with one or more R ^π 's, (s) heterocyclyl optionally substituted with one or more R ¹¹ 's, or

(t) -NR ⁸ (CO)OR ²¹ ,

provided that both R ² and R ³ are not simultaneously hydrogen;

R ⁴ is:

(a) hydrogen,

(b) d-Cjo-alkyl,

(C) -COCd-C^-alkyl,

(d) -COaryl,

(e) -COheterocyclyl,

OD -CO ₂ (C ₁ -C ₆ )-alkyl,

(g) -CO ₂ aryl,

(h) -CO ₂ heterocyclyl,

(i) -CONR ⁸ R ⁹ , ω -S(O) _n -alkyl,

(k) -S(O) _n -aryl,

(1) -S(O) _n -heterocyclyl, or

(m) -S(O) _n - NR ⁸ R ⁹ ;

or , wherein the dashed line(s) represent an optional double bond;

T is O, S, C=O, N, NR ¹⁹ or C(R ^2O ) _P ;

Q, X, U, V and W are independently O, S, C=O, N, NR ¹⁹ or C(R ^2O ) _P , provided that Q is not C(R ^2O ) _P when X is N or NR ¹⁹ ;

R ⁸ and R ⁹ are independently:

(a) hydrogen,

(b) -[(C=O)OJ _s aryl, wherein the aryl may be optionally substituted with one or more R ¹ 's,

(c) -[(C=O)O _r ] _s (C ₂ -C ₈ )-alkenyl, wherein the alkenyl may be optionally substituted with one or more R ¹⁴ 's,

(d) -[(C=O)O _r ] _s (C ₁ -C ₈ )allcyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's, (e) -S(O) _p (Ci-C ₈ )alkyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's,

(g) -C(=NR ¹⁸ )(NR ¹⁶ R ¹⁷ ), or

(h) heterocyclyl optionally substituted with one or more R ¹⁴ 's, or R ⁸ and R ⁹ are taken together with the nitrogen to which both are attached to form a 3- to 8-membered ring, which may optionally contain 1-4 heteroatoms selected from N, O, and S and be optionally substituted with one or more R ¹⁴ 's;

R ¹⁰ is:

(a) halo,

(b) -OH,

(C) -O[(C=O)O _r ]s(C ₁ -C ₆ )-alkyl,

(φ -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(e) -O[(C=O)O _r ] _s aryl,

CD -O[(C=O)O _r ] _s heteroaryl,

(g) (d-C^-alkyl-SCOV,

(h) aryl-(C i -C ₆ )alkyloxy-,

(0 cyano, ω nitro,

(k) -NR ⁸ R ⁹ ,

(1) -0(CO)NR ⁸ R ⁹ ,

(m) -CHO,

(n) -COOH,

(o) -CO(Ci-C ₆ )-alkyl,

(P) -CO ₂ (C ₁ -C ₆ )-alkyl,

(q) -CONR ⁸ R ⁹ ,

(r) aryl, ^< which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (d-C^-alkyl-SCOV,

9) cyano,

10) -COOH,

H) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(s) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C^-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C ₁ -C ₆ )-alkyloxy,

9) cyano,

10) -COOH,

H) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (d-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ , (t) heterocyclo other than heteroaryl wliich is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-QO-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkj4-S(O)n-,

9) cyano,

10) -COOH,

11) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(u) benzyl-S(O) _n -,

(v) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alk5d-S(O)n-,

5) cyano,

6) -COOH,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(Ci-C ₆ )-alkyl, and 12) -0(C=O)NR ⁸ R ⁹ ,

(w) (C ₂ -C io)-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (CrC^-alkyloxy,

5) cyano,

6) -COOH,

7) -CO(C ₁ -C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(x) -(Ci-Cio)-alkyl, which may optionally be substituted with one or more substituents selected [ from the group consisting of:

1) halo,

2) -OH,

3) (CrC ₆ )-alkyloxy,

4) (d-QO-alkyl-StOV,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(C _r C ₆ )-alkyl,

9) -CO ₂ (Ci-C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ ,

12) -O(C=O)-(Ci-C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ;

R ¹¹ Is:

(a) halo,

(b) -OH,

(C) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-a]kyl,

(φ -O[(C-O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(e) -O[(C=O)O _r ] _s aryl,

(f) -O[(C=O)O _r ] _s heteroaryl,

(g) (Ci-C ₆ )-alkyl-S(O) _n -,

Ch) aryl-(C i -C ₆ )alkyloxy-,

(i) cyano,

G ⁾ -NR ⁸ R ⁹ ,

(k) -0(CO)NR ⁸ R ⁹ ,

(1) -COOH,

(m) -CO(Ci-C ₆ )-alkyl,

(n) -CO ₂ (Ci-C ₆ )-alkyl,

(o) -CONR ⁸ R ⁹ ,

(P) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C^-alkyl,

4) aryl-(Ci-C ₆ )alkyloxy-,

5) (Ci-C ₄ )-perfluoroalkyl,

6) (C ₂ -C ₆ )-alkenyl,

7) (C ₂ -C ₆ )-alkynyl,

8) (Ci-C ₆ )-alkyloxy,

9) (Ci-C ₆ )-alkyl-S(O) _n -,

10) cyano,

11) -COOH,

12) -CO(C _r C ₆ )-alkyl,

13) -CO ₂ (C _r C ₆ )-alkyl,

14) -CONR ⁸ R ⁹ ,

15) -NR ⁸ R ⁹ , 16) -O(C=O)-(C ₁ -C ₆ )-allcyl, and

17) -0(C-O)NR ⁸ R ⁹ ,

(q) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

I) halo, 2) -OH,

3) (Ci-C ₆ )-alkyl,

4) aryl-(C ₁ -C ₆ )alkyloxy-,

5) (Ci-C ₄ )-perfluoroatkyl,

6) (C ₂ -C ₆ )-alkenyl, 7) (C ₂ -C ₆ )-alkynyl,

8) (C ₁ -C ₆ )-alkyloxy,

9) (Ci-C ₆ )-alkyl-S(O) _n -,

10) cyano,

I I) -COOH, 12) -CO(Ci-C ₆ )-alkyl,

13) -CO ₂ (Ci-C ₆ )-alkyl,

14) -CONR ⁸ R ⁹ ,

15) -NR ⁸ R ⁹ ,

16) -O(C=O)-(C _! -C ₆ )-alkyl, and 17) -0(C=O)NR ⁸ R ⁹ ,

(r) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (Ci-C^-alkyl,

4) aryl-(CrC ₆ )alkyloxy-,

5) (d-C^-perfluoroalkyl,

6) (C ₂ -C ₆ )-alkenyl,

7) (C ₂ -C ₆ )-alkynyl,

8) (Ci-C ₆ )-alkyloxy, 10) cyano,

11) -COOH,

12) -CO(Ci-C ₆ )-alkyl,

13) -CO ₂ (C ₁ -C ₆ )-alkyl,

14) -CONR ⁸ R ⁹ , 15) -NR ⁸ R ⁹ ,

16) -O(C-O)-(C _r C ₆ )-alkyl, and

17) -0(C=O)NR ⁸ R ⁹ ,

(s) -(C ₂ -C io)-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

4) (C ₁ -Ce)-^yI-S(O) _n -,

5) phenyl-(C rC ₆ )-alkyloxy-,

6) cyano,

7) -CHO,

8) -COOH,

9) -CO(C _! -C ₆ )-alkyl,

10) -CO ₂ (Ci-C ₆ )-alkyl,

H) -CONR ⁸ R ⁹ ,

12) -NR ⁸ R ⁹ ,

13) aryl,

14) heteroaryl as defined above,

15) heterocyclo other than heteroaryl as defined above,

16) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

17) -0(C=O)NR ⁸ R ⁹ ,

(t) (C ₂ -C ₁ o)-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) (C ₁ -Cg)-^yI-S(O) _n -,

5) phenyl-(Ci-C ₆ )-alkyloxy-,

6) cyano,

7) vinyl,

8) -CHO,

9) -COOH,

10) -CO(Ci-C ₆ )-alkyl,

H) -CO ₂ (Ci-C ₆ )-alkyl,

12) -CONR ⁸ R ⁹ ,

13) -NR ⁸ R ⁹ ,

14) aryl, wherein aryl is defined as above,

15) heteroaryl as defined above,

16) heterocyclyl other than heteroaryl as defined above,

17) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

18) -0(C=O)NR ⁸ R ⁹ ,

(u) -(C ₁ -C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected I from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alkyl-S(O)π-,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(Ci-C ₆ )-alkyl,

9) -CO ₂ (Ci-C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ,

(v) -O(CH ₂ ) _m -heteroaryl as defined above;

R ¹² Is:

(a) halo,

(b) -OH, (d) -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(e) -O[(C=O)O _r ],aryl,

(f) -O[(C=O)O _r ] _s heteroaryl,

(g) (C ₁ -C ₆ )-alkyl-S(O) _n -, (h) aryl-(C ₁ -C ₆ )alkyloxy-, (i) cyano,

(D nitro,

(k) -NR ⁸ R ⁹ ,

(1) -0(CO)NR ⁸ R ⁹ ,

(m) -CHO, (n) -COOH,

(o) -COtCrCO-alkyl,

(P) -CO ₂ (Ci-C ₆ )-alkyl,

(q) -CONR ⁸ R ⁹ ,

(r) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C ₁ -C ₆ HIkVl,

4) (Q-C^-perfluoroalkyl, 5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (d-C ₆ )-alkyl-S(O) _n -,

9) cyano,

10) -COOH,

11) -CO(d-C ₆ )-alkyl, 12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -0(C=O)-(Ci-C ₆ )-a]J£yl, and

16) -0(C=O)NR ⁸ R ⁹ , (s) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (d-C ₆ )-alkyloxy,

8) (d-C ₆ )-alkyl-S(O) _n -,

9) cyano,

10) -COOH,

H) -CO(d-C ₆ )-alkyl,

12) -CO ₂ (d-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(d-C ₆ )-alkyl, and

16) -0(C-O)NR ⁸ R ⁹ ,

(t) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C ₆ )-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C ₁ -C ₆ )-alkyloxy,

8) (C ₁ -C ₆ )-alkyl-S(O) _n - ₅

9) cyano,

10) -COOH,

H) -CO(C _r C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(U) benzyl-S(O) _n -, (V) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

5) cyano,

6) -COOH,

7) -CO(d-C ₆ )-alkyl,

8) -CO ₂ (C _r C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(w) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-aJkyloxy,

4) (d-C^-alkyl-SCOV,

5) cyano,

6) -COOH, 7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (C ₁ -C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(Ci-C ₆ )-aIkyl, and 12) -0(C=O)NR ⁸ R ⁹ ,

(x) -(C ₁ -C _1O )-EIlCyI, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C _r C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alkyl-S(O) _n -,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(C _r C ₆ )-alkyl,

9) -CO ₂ (C _r C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C _r C ₆ )-alkyL

13) -0(C=O)NR ⁸ R ⁹ ,

(y) =O;

R ¹⁴ is:

(a) halo,

(b) -OH,

(C) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(φ -O[(C=O)O _r ] _s (C ₂ -C ₆ )-aikenyl,

(e) -O[(C=O)O _r ] _s aryl,

(f) -O[(C=O)O _r ] _s heteroaryl,

(g) (C ₁ -Ce)-EIlCyI-S(O) _n -, (h) aryl-(Ci-C ₆ )alkyloxy-, (i) cyano,

0 ^' ) nitro,

(k) -NR ⁸ R ⁹ ,

(1) -0(CO)NR ⁸ R ⁹ ,

(m) -CHO, (n) -COOH,

(o) -CO(Ci-C ₆ )-alkyl,

(p) -CO ₂ (C ₁ -C ₆ )-alkyl,

(q) -CONR ⁸ R ⁹ ,

(r) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-QO-alkyi,

4) (Ci-C ₄ )-perfluoroalkyl, 5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (C _r C ₆ )-alkyl-S(O) _n -,

9) cyano, 10) -COOH,

11) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

16) -0(C=O)NR ⁸ R ⁹ ,

(s) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH ₅ 3) (Ci-C ₆ )-alkyl,

4) (CrC^-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (d-CO-alkyl-SfPV,

9) cyano,

10) -COOH,

H) -CO(C _! -C ₆ )-alkyl,

12) -CO ₂ (C _r C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(t) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (CrOO-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C ₁ -C ₆ )-alkyloxy,

8) (Ci-Ce)-BIk^-S(O) _n -,

9) cyano,

10) -COOH,

H) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyi, and

16) -0(C=O)NR ⁸ R ⁹ , (u) beiizyl-S(O) _a -,

(v) (C2-C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (C _r C ₆ )-alkyloxy,

4) (d-C^-alkyl-SCOV,

5) cyano,

6) -COOH,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -0(O=0)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(w) (C ₂ -C ₁ o)-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (C ₁ -Q)-^l-S(O) _n -,

5) cyano,

6) -COOH,

7) -CO(Ci-Q)-alkyl,

8) -CO ₂ (C ₁ -C ₆ )-alkyl, 9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(x) -(Ci-CicO-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-allcyloxy,

4) (Ci-C ₆ )-aJkyl-S(O) _n -,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(C ₁ -C ₆ )-alkyl,

9) -CO ₂ (Ci-C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C _r C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ;

R ¹⁶ and R ¹⁷ are independently:

(a) aryl, - which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C^-alkyl,

4) (Ci-C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Q-C _f O-alkyloxy,

8) (CrC ₆ )-alkyl-S(O)n-,

9) cyano,

10) -COOH,

H) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ , (b) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Q-QO-alkyl, 4) (Ci-C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C _r C ₆ )-alkyloxy,

8) (C ₁ -C ₆ )-alkyl-S(O) _n -, 9) cyano,

10) -COOH,

11) -COCQ-CO-alkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ , 14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(c) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-C^-alkyl,

4) (Q-GO-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl, 6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Cj-QD-alkyl-StOV,

9) cyano,

10) -COOH,

11) -CO(Ci-C ₆ )-aJkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl, 13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(d) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) (Ci-CeD-alkyl-SCOV, 5) cyano,

6) -COOH,

7) -CO(d-C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ , 10) -NR ⁸ R ⁹ ,

11) -0(CO)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(e) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

5) cyano, 6) -COOH,

7) -CO(d-C ₆ )-alkyl,

8) -COstd-CeO-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

12) -0(C=O)NR ⁸ R ⁹ , (f) -(C _t -C _ϊ ^-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (CrC^-alkyloxy, 4) (Ci-C ₆ )-alkyl-S(O) _n -,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(Ci-C ₆ )-alkyl, 9) -CO ₂ (C ₁ -C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ ,

12) -O(C=O)-(Ci-C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ , or R ¹⁶ and R ¹⁷ are taken together with the nitrogen to which both are attached to form a 3- to 8-membered ring, which may optionally contain 1-4 heteroatoms selected from N, O, and S and be optionally substituted with one or more R ¹⁴ 's;

R ¹⁸ is cyano, -COR ¹⁶ or -SO ₂ R ¹⁶ ;

R ¹⁹ is:

(a) hydrogen,

(b) (d-C^-alkyl,

(C) -CO(Ci-C ₆ )-alkyl,

(d) -CO(C ₁ -C ₆ )^FyI,

(e) -CO(Ci-C ₆ )-heteroaryl,

00 -CO ₂ (C ₁ -C ₆ )-alkyl,

(g) CO ₂ (C ₁ -C ₆ )-aryl,

(h) CO ₂ (C ₁ -C ₆ )-heteroaryl,

(i) -CONR ⁸ R ⁹ ,

G ⁾ -S(O) _n -alkyl,

(k) -S(O) _n -aryl,

(1) -S(O) _n -heteroaryl, or

(m) -S(O) _n - NR ⁸ R ⁹ ;

R ²⁰ is independently:

(a) hydrogen,

(b) halo,

(C) -OH,

(d) -O[(C=O)O _r ] _s (CrC ₆ )-alkyl,

(e) -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(f) -O[(C=O)O _r ] _s aryl,

(g) -O[(C=O)O _r ] _s heteroaryl,

(h) (d-C^-alkyl-SCOV,

(i) aryl-(Ci-C ₆ )alkyloxy-,

0 ⁾ cyano,

(k) nitro,

(1) -NR ⁸ R ⁹ ,

(m) -0(CO)NR ⁸ R ⁹ ,

(n) -CHO,

(o) COOH,

(P) -CO(d-C ₆ )-alkyl,

(q) -CO ₂ (Ci-C ₆ )-alkyl,

(r) -CONR ⁸ R ⁹ ,

(S) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (C ₁ -C ₄ )-perfluoroalkyl ₅

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C ₁ -C ₆ )-alkyloxy, 8) (Ci-C ₆ )-alkyl-S(O)n-,

9) cyano,

10) -COOH ₅

11) -CO(Ci-C ₆ )-alkyl,

12) -COzCd-C^-alkyl, 13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(t) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-QO-aJiyl,

4) (Ci-C ₄ )-perfluoroalkyl, 5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkyl-S(OV,

9) cyano, 10) -COOH,

11) -CO(Ci-C ₆ )-alkyl,

12) -COsCd-C^-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ , 15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(u) heterocyclo other than lieteroaryl which is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-QO-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

V) (Ci-C^-alkyloxy,

8) (C ₁ -C ₆ HIkVl-S(O) _n -,

9) cyano,

10) -COOH,

H) -CO(C _r C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and

16) -Q(C=O)NR ⁸ R ⁹ ,

(v) benzyl-S(O) _n -,

(w) (C ₂ -C io)-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alkyl-S(O) _n -,

5) cyano,

6) -COOH,

7) -CO(Cj-C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(d-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(x) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) (d-C^-alkyl-S^),-,

5) cyano,

6) -COOH,

V) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (C ₁ -C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

12) -0(C=O)NR ⁸ R ⁹ ,

(y) -(Ci-C io^alkyl, which may optionally be substituted with one or more substituents selected . from the group consisting of:

1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(C ₁ -C ₆ )-alkyl,

9) -CO ₂ (C ₁ -C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

H) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C _r C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ;

R ²¹ is:

(a) Ci-Cio-alkyl optionally substituted with one or more R ¹¹ 's,

(b) C ₃ -C ₈ -cycloalkyl optionally substituted with one or more R ¹¹ 's,

(c) aryl optionally substituted with one or more R ^{1 !} 's, or

(d) heterocyclyl optionally substituted with one or more R ¹¹ 's;

m is 1 to 5; n is 0 to 3; p is 1 or 2; r is 0 to 5; and s is 0 to 4;

with the following provisos:

a) excluding compounds wherein: R ¹ is phenyl, which may be optionally substituted with one or more

R ¹⁰ 's; one of R ² or R ³ is hydrogen and the other R ² or R ³ is Ci-C- ₇ -alkyl; R ⁴ is hydrogen;

R ¹² is -NR ⁸ R ⁹ , wherein R ⁸ is hydrogen; and R ⁹ is phenyl or phenylalkyl, wherein the phenyl may be optionally substituted with halo, (Ci-C ₆ )-alkyl, perfluoromethyl, (C _r C ₆ )-alkyloxy, cyano, -CO ₂ (C ₁ -C ₆ )-alkyl, or -CONR ⁸ R ⁹ , wherein R ⁸ is H and R ⁹ is H or (C _r C ₇ )alkyl; and

b) excluding compounds wherein:

R ¹ is aryl or pyridyl, which may be optionally substituted with one or more R ¹⁰ 's; one R \ J. o _ .r„ T R"> J i 's __ T h _-1 -y-d Jr-,o-.g , en and the o jt.ih_er T R-j 2 o _ _^ r. R 3 is Q-Q-alkyl or both R ² and R ³ are C ₁ -C ₄ -alkyl;

R ⁴ is H;

R is , which may be optionally substituted with one

1 "X or more R 's; and

R ²⁰ contains an optionally substituted 4-pyridinylalkylene moiety, an optionally substituted 4-pyrimidinylalkylene moiety, or an optionally substituted 4-triazinylalkylene moiety.

2. The compound of claim 1, wherein:

R ¹ is an aryl or heterocyclic ring, which may be optionally substituted with one or more R ¹⁰ 's;

R and R are independently:

(a) halo,

(b) (Ci-C ₆ )-aIkoxy optionally substituted with one or more R ^π 's,

(C) (C i -C ₄ )-perfluoroalkyl,

(φ -CO(Ci-C ₆ )-alkyl,

(e) -CO ₂ (C _r C ₆ )-alkyl,

CD -CONR ⁸ R ⁹ ,

(g) -0(CO)NR ⁸ R ⁹ ,

(h) -NR ⁸ (CO)NR ⁸ R ⁹ ,

(i) -NR ⁸ R ⁹ ,

G) hydrogen,

(k) Ci-CiQ-alkyl optionally substituted with one or more R ^π 's,

(1) aryl optionally substituted with one or more R ^π 's,

(m) heterocyclyl optionally substituted with one or more R ^π 's, or

(n) -NR ⁸ (CO)OR ²¹ , provided that both R and R are not simultaneously hydrogen;

R ⁴ Is:

(a) hydrogen,

(b) Ci-Cio-alkyl, (C) -CO(Ci-C ₆ )-alkyl,

(d) -COaryl,

(e) -COheterocyclyl,

(g) CO ₂ aryl, or (h) CO ₂ heterocyclyl;

Q is a O, C=O, N, NR ¹⁹ or C(R ²⁰ ) _p ;

T is O, S, C=O, N, NR ¹⁹ or C(R ^2O ) _P ;

X, U, V and W are independently O, C=O or C(R ^2O ) _P ;

R ⁸ and R ⁹ are independently:

(a) hydrogen,

(b) -[(C=O)O _r ] _s aryl, wherein the aryl may be optionally substituted with one or more R ¹ 's,

(c) -[(C=O)O _r ] _s (C ₂ -Cs)-alkenyl, wherein the alkenyl may be optionally substituted with one or more R ¹⁴ 's,

(d) -[(C=O)O _r ] _s (C ₁ -Cg)alkyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's,

(e) -S(O) _p (C ₁ -C ₈ )alkyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's,

(f) heterocyclyl optionally substituted with one or more R ¹⁴ 's;

R ¹⁰ is:

(a) halo, (b) -OH,

(c) -0[(O0)0 _r ] _s (Ci-C ₆ )-aIkyl,

(d) -O[(C=O)O _r ]s(C ₂ -C ₆ )-alkenyl,

(e) -O[(C=O)O _r ] _s aryl,

(f) -O[(C=O)O _r ] _s heteroaryl, (g) cyano,

(h) nitro, (i) -NR ⁸ R ⁹ , 0 ^' ) -0(CO)NR ⁸ R ⁹ , (k) -CO(C ₁ -C ₆ )-alkyl, (1) -CO ₂ (C ₁ -C ₆ )-alkyl,

(m) -CONR ⁸ R ⁹ ,

(n) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

I) halo, 2) -OH,

3) (d-C^-alkyl,

4) (Q-C^-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy,

6) cyano, 7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (CrC ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

II) -O(C=O)-(Ci-C ₆ )-alkyl, and 12) -0(C=O)NR ⁸ R ⁹ ,

(o) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Q-QO-alkyl,

4) (C ₁ -C ₄ )-perfluoroalkyl, 5) (C ₁ -C ₆ )-alkyloxy,

6) cyano,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (C ₁ -C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ , 10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(p) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Q-QO-alkyl,

4) (Ci-C^-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy, 6) cyano,

7) -CO(Ci-C ₆ )-aJkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ , 11) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(q) -(C ₁ -C ₁ o)-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo, 2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) cyano,

5) -CO(Ci-C ₆ )-alkyl,

6) -CO ₂ (Ci-C ₆ )-alkyl,

7) -CONR ⁸ R ⁹ ,

8) -NR ⁸ R ⁹ , 9) -O(C=0)-(Ci-C ₆ )-alkyl, and

10) -0(C-O)NR ⁸ R ⁹ ;

R ¹¹ is:

(a) halo, (b) -OH,

(c) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(d) -O[(C=O)O _r ] _s aryl,

(e) -O[(C=O)O _r ] _s heteroaryl,

(f) cyano, (g) -NR ⁸ R ⁹ ,

(h) -0(CO)NR ⁸ R ⁹ , (i) -CO(C ₁ -C ₆ )-alkyl, G) -CO ₂ (Ci-C ₆ )-alkyl, (k) -CONR ⁸ R ⁹ , (1) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C ₆ )-alkyl, 4) (Ci-C^-perfluoroalkyl,

5) (Ci-Ce)-alkyloxy,

6) cyano,

7) -COtCrC^-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl, 9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(C _r C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(m) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) aryl-(Ci-C ₆ )alkyloxy-,

5) (C i -C ₄ )-perfluoroalkyl,

6) (C _r C ₆ )-alkyloxy,

7) cyano,

8) -CO(Ci-C ₆ )-alkyl,

9) -CO ₂ (Ci-C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

H) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ,

(n) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C ₆ )-alkyl,

4) (C ₁ -C ₄ )-perfluoroalkyl,

5) (C ₁ -C ₆ )-alkyloxy,

6) cyano,

7) -CO(Cj-C ₆ )~alkyl,

8) -CO ₂ (Ci-C ₆ VaIkYl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -0(0OV(Ci-C ₆ VaIkYl, and

12) -0(-C=O)NR ⁸ R ⁹ ,

(o) -(Ci-Cio)-alkyl, which may optionally be substituted with one or more substituents selected L from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) cyano, 5) -COOH,

6) -CO(C _r C ₆ )-alkyl,

7) -CO ₂ (C _r C ₆ )-alkyl,

8) -CONR ⁸ R ⁹ ,

9) -NR ⁸ R ⁹ , 10) -O(C=O)-(Ci-C ₆ )-alkyl, and

H) -0(C=O)NR ⁸ R ⁹ ,

(p) -O(CH ₂ ) _m -heteroaryl as defined above;

R ¹² Is:

(a) halo,

(b) -OH,

(C) -0[(C=O)0 _r ] _s (Ci-C ₆ )-alkyl,

(d) -O[(C=O)O _r ] _s aryl,

(e) -O[(C=O)O _r ] _s heteroaryl,

(f) cyano,

(g) nitro,

(h) -NR ⁸ R ⁹ ,

(i) -0(CO)NR ⁸ R ⁹ ,

G) -CO^rCg)^!^!,

(k) -CO ₂ (Ci-C ₆ )-alkyl,

(1) -CONR ⁸ R ⁹ ,

(m) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C^-alkyl,

4) (Ci-C ₄ )-perfluoroancyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C< ₅ )-alkynyl,

7) (Q-C^-alkyloxy,

8) cyano, 9) -COOH,

10) -CO(Ci-C ₆ )-alkyl,

11) -CO^Q-C^-alkyl,

12) -CONR ⁸ R ⁹ ,

13) -NR ⁸ R ⁹ , 14) -O(C=O)-(Ci-C ₆ )-alkyl, and

15) -0(C=O)NR ⁸ R ⁹ ,

(n) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

D halo, 2 2)) - -OOHH.,

3) (Ci-C ₆ )-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy,

6) cyano,

7) -COOH,

8) -CO(d-C ₆ )-alkyl,

9) -CO ₂ (C _r C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

H) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ,

(o) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

D halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4> (Ci-C ₄ )-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy,

6) cyano,

7) -CO(Ci-C ₆ )-alkyl,

8) -COzCQ-C^-alkyl, 9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -0(C-O)-(C ₁ -C ₆ )-!

12) -0(C=O)NR ⁸ R ⁹ ,

(p) -(C ₁ -C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) cyano,

5) -CO(C _r C ₆ )-alkyl,

6) -CO ₂ (C _r C ₆ )-alkyl,

7) -CONR ⁸ R ⁹ ,

8) -NR ⁸ R ⁹ ,

9) -0(C=O)-(C ₁ -C ₆ )^l

10) -0(C=O)NR ⁸ R ⁹ ,

(q) =0;

R ¹⁴ is:

(a) halo,

(b) -OH,

(C) -O[(O=0)0 _r ]s(Ci-C6)-alkyl,

(φ -O[(C=O)O _r ] _s aryl,

(e) -O[(C=O)O _r ] _s heteroaryl,

CO cyano,

(g) nitro,

(h) -NR ⁸ R 9

5

(0 -0(CO)NR ⁸ R ⁹ ,

0) -CO(C _r C ₆ )-alkyl, (k) -CO ₂ (Ci-C ₆ )-alkyl, (1) -CONR ⁸ R ⁹ ,

(m) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-CO-alkyl,

4) (Ci-C^-perfluoroalkyl,

5) (C ₁ -C ₆ )-alkyloxy,

6) cyano,

7) -COCCrCeO-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(n) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Q-CeO-alkyl,

4) (Q-C^-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy,

6) cyano,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (d-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(C _r C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(o) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (d-C ₆ )-alkyl,

4) (Ci-C^-perfluoroalkyl,

5) (d-C^-alkyloxy,

6) cyano,

7) -COCQ-C _t O-alkyl, 8) -CO ₂ (C _r C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(Ci-C ₆ )-alkyi, and

12) -0(C=O)NR ⁸ R ⁹ , (p) -(C ₁ -C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) cyano,

5) -CO(Ci-C ₆ )-alkyl,

6) -CO ₂ (Ci-C ₆ )-alkyl,

V) -CONR ⁸ R ⁹ ,

8) -NR ⁸ R ⁹ ,

9) -O(C=O)-(Ci-C ₆ )-alkyl, and

10) -0(C=O)NR ⁸ R ⁹ ;

R ¹⁹ is:

(a) hydrogi an,

(b) (Ci-QO-attyl,

(C) -CO(C i-C ₆ )-alkyl,

(d) -CO(C i-CβVaryl,

(e) -CO(C _r C ₆ )-heteroaryl,

(li) CO ₂ (C ₁ -C ₆ )-heteroaryl, or (i) -CONR ⁸ R ⁹ ;

R ²⁰ Is:

(a) hydrogen,

(b) halo, (c) -OH,

(d) -O[(C=O)O _r ] _s (d-C ₆ )-alkyl,

(e) -O[(C=O)O _r ] _s aryl,

(f) -O[(C=O)O _r ] _s heteroaryl,

(g) cyano, (h) nitro,

(i) -NR ⁸ R ⁹ , 0) -0(CO)NR ⁸ R ⁹ , (k) -CO(C ₁ -C ₆ )^IlCyI, (m) -CONR ⁸ R ⁹ ,

(n) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (Ci-C ₆ )-alkyl,

4) (CrC^-perfluoroalkyl,

5) (d-C _t O-alkyloxy,

6) cyano, 8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

12) -0(C=O)NR ⁸ R ⁹ ,

(o) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C _! -C ₆ )-alkyl,

5) (Ci-C ₆ )-alkyloxy,

6) cyano,

7) -CO(Ci-Qi)-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(C _r C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(p) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy,

6) cyano,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (Cj-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ , and

10) -NR ⁸ R ⁹ ,

(q) -(C ₁ -C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected '. from the group consisting of:

D halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) cyano,

5) -CO(Ci-C ₆ )-alkyl,

6) -CO ₂ (Ci-C ₆ )-alkyl,

7) -CONR ⁸ R ⁹ ,

8) -NR ⁸ R ⁹ ,

10) -0(C=O)NR ⁸ R ⁹ ;

R ²¹ is:

(a) optionally substituted with one or more R ⁿ 's,

(b) aryl optionally substituted with one or more R ¹¹ ' s, or

(c) heterocyclyl optionally substituted with one or more R ¹ * ' s;

m is l to 4; p is 1 or 2; r is 0 to 4; and s is 0 to 3.

3. The compound of claim 1, wherein:

R ¹ is an aryl or heterocyclic ring, which may be optionally substituted with one or more R ¹⁰ 's;

R and R are independently:

(a) halo,

(b) (Ci-C ₆ )-alkoxy optionally substituted with one or more R ¹¹ 's,

(c) (C ₁ -C ₄ )-perfluoroalkyl, (d) hydrogen,

(e) Ci-Cio-alkyl optionally substituted with one or more R ^π 's,

(f) aryl optionally substituted with one or more R ^{1 !} 's, or

(g) heterocyclyl optionally substituted with one or more R ^{1 !} 's, provided that both R ² and R ³ are not simultaneously hydrogen;

R ⁴ is:

(a) hydrogen,

(b) Ci-Cio-alkyl,

(C) -COCd-C^-allcyl,

(d) -CO(Ci-C ₆ )-aryl, or

(e) -CO(C _! -C ₆ )-heteroaryl;

Q is a O, C=O, N, NR ¹⁹ or CR ²⁰ ;

T is O, S, C=O, N or NR ¹⁹ ;

X, U, V and W are independently O, C=O or CR ²⁰ ;

R ⁸ and R ⁹ are independently: (a) hydrogen,

(b) -[(C=O)OJ _s aryl, wherein the aryl may be optionally substituted with one or more R ¹⁴ 's,

(c) -[(C=O)O _r ] _s (C ₁ -Cg)alkyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's, (d) heterocyclyl optionally substituted with one or more R ¹⁴ 's;

R ¹⁰ Is:

(a) halo,

(b) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(c) -O[(C=O)O _r ] _s aryl,

(d) -O[(C=O)O _r Jsheteroaryl,

(e) cyano,

(f) nitro, (g) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C ₆ )-alkyl, 4) (Q-Qyperfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy, and

6) cyano,

(h) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-C ₆ )-alkyl,

4) (Ci-C ₄ )-perfluoroalkyl,

5) (CrC ₆ )-alkyloxy, and 6) cyano,

(i) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (Ci-C ₆ )-alkyl,

4) (Ci-C^-perfluoroalkyl,

5) (Ci-C ₆ )-alkyloxy, and

6) cyano,

(j) -(C ₁ -Cio)-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo, T) -OH,

3) (Q-C^-alkyloxy, and

4) cyano;

R ¹¹ Is: (a) halo,

(b) -OH,

(c) -O[(C=O)O _r ] _s (C _r C ₆ )-alkyl,

(d) -O[(C=O)O _r ] _s aryl,

(e) -O[(C=O)O _r ] _s heteroaryl, (f) -NR ⁸ R ⁹ , provided that neither R ⁸ nor R ⁹ in this instance is -C(=O)- phenyl,

(g) -0(CO)NR ⁸ R ⁹ ,

(h) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyl,

5) (Q-C _f O-alkyloxy, and 6) cyano,

(i) heteroaryl optionally substituted with one or more substiruents selected from the group consisting of:

1) halo,

2) -OH, 3) (Ci-QO-alkyl,

4) aryKQ-C _f Oalkyloxy-,

6) (Q-C^-alkyloxy, and

7) cyano, (j) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (Ci-C4)-perfluoroalkyl,

5) (C ₁ -C ₆ )-allςyloxy, and 6) cyano,

(Ic) -(C ₁ -C ₁ o)-allcyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (Ci-C ₆ )-alkyloxy,

4) cyano, and

5) -COOH,

(1) — O(CH ₂ ) _m -heteroaryl as defined above;

R ¹² is:

(a) halo,

(b) -O[(C=O)O _r ] _s (d-C ₆ )-alkyl,

(c) -O[(C=O)O _r ] _s aryl,

(d) -O[(C=O)O _r ] _s heteroaryl, (e) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl, 4) (CrC^-perfluoroalkyl,

5) (Q-C^-alkyloxy, and

6) cyano,

(f) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (Ci-C4)-perfluoroalkyl,

5) (C ₁ -C ₆ )-alkyloxy,

6) cyano, and

7) -COOH, (g) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH ₅

3) (Ci-C ₆ )-alkyl, 4) (C ₁ -C ₄ )-perfluoroalkyl,

5) (d-C _f O-alkyloxy, and

6) cyano,

(h) which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Q-C^-alkyloxy, and

4) cyano,

(0 =0;

R ¹⁴ is:

(a) halo,

(b) -OH,

(d) -0[(O=0)0 _r ] _s aryl,

(e) -O[(C=O)O _r ] _s heteroaryl,

(f) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo, 2) -OH,

3) (CrQO-alkyl,

4) (C _r C ₄ )-ρerfluoroalkyl,

5) (C ₁ -Ce)-EIlCyIoXy, and

6) cyano,

(g) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-C ₆ )-alkyl,

4) (Ci-C ₄ )-ρerfluoroalkyl,

5) (Q-C _f O-alkyloxy, and 6) cyano,

(h) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (CrOO-alkyl,

5) (Q-C^-alkyloxy, and

6) cyano,

(i) -(C ₁ -C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Q-C^-alkyloxy, and

4) cyano;

R ¹⁹ is:

(a) hydrogen,

(b) (d-C ₆ )-alkyl,

(C) -COCCi-QD-alkyl,

(d) -CO ₂ (Ci-C ₆ )-alkyl, or

(e) -CONR ⁸ R ⁹ :

R ²⁰ Is:

(a) hydrogen,

(b) halo,

(c) -OH, (d) -O[(C=O)O _r J _s (C _r C ₆ )-alkyl,

(e) aryl, which may be optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (d-C ₆ )-alkyl,

4) (CrGO-perfluoroalkyl,

5) (C _r C ₆ )-alkyloxy, and

6) cyano,

(f) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C^-alkyl, 5) (CrC^-alkyloxy, and

6) cyano,

(g) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo, 2) -OH,

3) (Ci-OO-alkyl,

5) (Ci-C ₆ )-alkyloxy, and

6) cyano, (h) -(Ci-C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (C ₁ -C ₆ )-allcyloxy, and

4) cyano;

m is 1 to 3; r is 0 to 3; and s is 0 to 2.

4. The compound of claim 1, wherein:

R is an aryl or heterocyclic ring, which may be optionally substituted with one or more R ¹⁰ 's;

R ² and R ³ are independently:

(a) hydrogen,

(b) Ci-Cio-alkyl optionally substituted with one or more R ¹¹ 's,

(c) aryl optionally substituted with one or more R ¹ * 's, or

(d) heterocyclyl optionally substituted with one or more R ^{1 J} ' s, provided that both R ² and R ³ are not simultaneously hydrogen;

R ⁴ is hydrogen or Q-Qo-alkyl;

Q is a O, C=O, NR ¹⁹ or CR ²⁰ ;

T is O, S, C=O or NR ¹⁹ ;

X, U, V and W are independently C=O or CR ²⁰ ;

R and R are independently:

(a) hydrogen, (b) -[(C=O)O _r ] _s aryl,

(d) heterocyclyl;

(a) halo,

(C) -O[(C=O)O _r ] _s heteroaryl,

(d) aryl,

(e) heteroaryl,

00 heterocyclo, or

(g) -(Ci-Cio)-alkyl;

R ¹¹ Is:

(a) -OH,

(b) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(C) -O[(C=O)O _r ] _s aryl,

(d) -0[(C=0)O _r ] _s heteroaryl,

(e) -0(CO)NR ⁸ R ⁹ ,

(f) aryl,

(g) heteroaryl,

(h) heterocyclo,

© -(Ci-C ₁₀ )-alkyl, or

(D -O(CH ₂ ) _m -heteroaryl as defined above;

R ¹² is:

(a) halo,

(b) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(C) -O[(C=O)O _r ] _s aryl,

(d) -O[(C=O)O _r ] _s heteroaryl,

(e) aryl,

(f) heteroaryl, (g) heterocyclo,

00 -(Ci-Cio)-alkyl, and

(i) =0;

R ¹⁹ Is:

(a) hydrogen,

(b) (Ci-C ₆ )-alkyl, or

(C) -CONR ⁸ R ⁹ ;

R ²⁰ Is:

(a) hydrogen,

(b) halo,

(C) -0[(C=O)OJ ₈ (C ₁ -C ₆ )^Ik ₇ I,

(d) aryl,

(e) heteroaryl,

(f) heterocyclo,

(g) -(Ci-Cio)-alkyl;

m is 1 to 3; r is 0 to 3; and s is 0 to 2.

5. The compound of claim 1, wherein:

R ¹ is phenyl or pyridinyl, which may be optionally substituted with one or more R ¹⁰ 's;

R and R are independently:

(a) hydrogen,

(b) Q-Cio-alkyl optionally substituted with one or more R ¹ * 's,

(c) aryl optionally substituted with one or more R ¹¹ 's, or

(d) heterocyclyl optionally substituted with one or more R ¹¹ 's, provided that both R ² and R ³ are not simultaneously hydrogen;

R ⁴ is hydrogen;

Q is a O, C=O or CR ²⁰ ;

T is O, S or NR ¹⁹ ;

X, U, V and W are CR ²⁰ ;

R ⁸ and R ⁹ are independently:

(a) hydrogen,

(b) aryl, (c) -(Ci-Cg)alkyl, or

(d) heterocyclyl;

R ¹⁰ is:

(a) halo, (b) -O(Ci-C ₆ )-alkyl,

(c) -Oheteroaryl,

(d) aryl,

(e) heteroaryl,

(f) -(d-doHlkyl;

(g) -(Q-dcO-alkyl.

6. The compound of claim 1 wherein the compound is selected from the group of compounds set forth in the examples.

7. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of claim 1 and a pharmaceutically acceptable vehicle or carrier thereof.

8. Use of at least compound of the following formula I

I or a stereoisomer or a tautomer or a pharmaceutically acceptable salt or a prodrug thereof, in the manufacture of a medicament for treating or preventing arrhythmia, wherein:

R ¹ is an aryl or heterocyclic ring, which may be optionally substituted with one or more R ¹⁰ 's;

R ² and R ³ are independently:

(a) halo,

(b) (C i-C ₆ )-alkoxy optionally substituted with one or more R ^{1 J} ' s,

(c) (d-C ₄ )-perfluoroalkyl,

(d) (C ₁ -Ce)- lCyI-S(O) _n -,

(e) aryl-(CH ₂ ) _r -S(O) _n -,

(f) cyano,

(g) -CO ₂ H,

(h) -CO(CrC ₆ )-alkyl,

(i) -CO ₂ (Ci-C ₆ )-alkyl,

G ⁾ -CONR ⁸ R ⁹ ,

- 185 -

R ¹¹ Is:

(a) -O(d-C ₆ )-alkyl,

(b) -Oaryl,

(C) -Oheteroaryl,

(d) -0(CO)NR ⁸ R ⁹ ,

(e) aryl,

OD heteroaryl,

(g) -(Ci-Cio)-alkyl;

R ¹² Is:

(a) halo,

(b) -O(C ₁ -C ₆ )-alkyl,

(C) -Oaryl,

(d) -Oheteroaryl,

(e) aryl,

(f) heteroaryl,

(g) -(Ci-Cio)-alkyi, and

(h) =O;

R ¹⁹ Is:

(a) hydrogen,

(b) (Ci-C ₆ )-alkyl, or

(c) -CONR ⁸ R ⁹ ; and

R ²⁰ Is:

(a) hydrogen,

(b) halo,

(C) -OCQ-C _f O-alkyl,

(d) aryl,

(e) heteroaryl,

(f) heterocyclo, or

- 184 -

(k) -0(CO)NR ⁸ R ⁹ ,

(1) -NR ⁸ (CO)NR ⁸ R ⁹ ,

(m) -NR ⁸ R ⁹ ,

(n) hydrogen, (o) C ₁ -C ₁ o-alkyl optionally substituted with one or more R ¹ * ' s,

(p) (C ₂ -C ₁₀ )-alkenyl optionally substituted with one or more R ¹ * 's,

(q) (C ₂ -C ₁ o)-alkynyl optionally substituted with one or more R ¹¹ 's,

(r) aryl optionally substituted with one or more R ¹¹ 's,

(s) heterocyclyl optionally substituted with one or more R ¹¹ 's, or (t) -NR ⁸ (CO)OR ²¹ , provided that both R ² and R ³ are not simultaneously hydrogen;

R ⁴ is:

(a) hydrogen,

(b) Ci-C ₁₀ -alkyl,

(C) -CO(Ci-C ₆ )-alkyl,

(d) -COaryl,

(e) -COheterocyclyl,

09 -CO ₂ (C ₁ -C ₆ )-alkyl,

(g) -CO ₂ aryl,

(h) -CO ₂ heterocyclyl,

(i) -CONR ⁸ R ⁹ ,

0) -S(O) _n -alkyl,

(k) -S(O) _n -aryl,

(1) -S(O) _n -heterocyclyl, or

(m) -S(O) _n - NR ⁸ R ⁹ ;

R ⁵ is , wherein the dashed line(s) represent an optional double bond;

T is O, S, C=O, N, NR ¹⁹ or C(R ²⁰ ) _p ;

Q, X ₅ U, V and W are independently O, S, C=O, N, NR ¹⁹ or C(R ^2O ) _P , provided that Q is not C(R ^2O ) _P when X is N or NR ¹⁹ ;

R and R are independently:

(a) hydrogen,

(b) -[(C=O)O _r ] _s aryl, wherein the aryl may be optionally substituted with one or more R ¹⁴ 's,

(c) -[(C=O)Or] _s (C ₂ -C ₈ )-alkenyl, wherein the alkenyl may be optionally substituted with one or more R ¹⁴ 's,

(d) -[(C=O)O _r ] _s (Ci-C ₈ )alkyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's, (e) — S(O) _p (Ci-C ₈ )alkyl, wherein the alkyl may be optionally substituted with one or more R ¹⁴ 's,

(f) -S(O)pNR ¹⁶ R ¹⁷ ,

(g) -C(=NR ¹⁸ )(NR ¹⁶ R ¹⁷ ), or

(h) heterocyclyl optionally substituted with one or more R ¹⁴ 's, or R ⁸ and R ⁹ are taken together with the nitrogen to which both are attached to form a 3- to 8-membered ring, which may optionally contain 1-4 heteroatoms selected from N, O, and S and be optionally substituted with one or more R ¹⁴ 's;

R ¹⁰ is:

(a) halo,

(b) -OH,

(C) -O[(C=O)O _r ] _s (Ci-C ₆ )-aIkyl,

(d) -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(e) -0[(O=0)0 _r ] _s aryl,

CD -O[(C=O)O _r ] _s heteroaryl,

(h) aryKQ-CfOalkyloxy-,

(i) cyano, (j) nitro, (k) -NR ⁸ R ⁹ , (1) -0(CO)NR ⁸ R ⁹ , (m) -CHO ₅

(n) -COOH, (o) -COCd-C^-alkyl, (p) -CO ₂ (C _r C ₆ )-alkyl, (q) -CONR ⁸ R ⁹ , (r) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-QO-alkyl, 4) (C ₁ -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (C ₁ -Ce)-^yI-S(O) _n -, 9) cyano,

10) -COOH,

11) -COtQ-C^-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ , 14) -NR ⁸ R ⁹ ,

15) -OtC^OHd-C^-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(s) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH, 3> (Ci-C ₆ )-alkyl,

4) (Ci-Q)-ρerflu(Moalkyl.

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C ₁ -Ce)-EIlCyIoXy, 8) (Ci-C ₆ )-alkyl-S(O) _n -,

9) cyano,

10) -COOH,

11) -COCQ-QO-alkyl,

12) -CO ₂ (C _r C ₆ )-alkyl, 13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -OiTMTKCrC^-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(t) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Q-QO-alkyl, 5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C^-alkyloxy,

8) (C ₁ -C ₆ )^Ik ₇ I-S(O) _n -,

9) cyano, 10) -COOH,

11) -OXCi-QO-alkyl,

12) -CO ₂ (d-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ , 15) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ , (u) benzyl-S(O) _n ~,

(v) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alkyl-S(O) _n -,

5) cyano,

6) -COOH,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (C _r C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(W) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alkyi-S(O) _n -,

5) cyano,

6) -COOH,

7) -CO(Ci-C ₆ )-alkyl, 9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -OtCOHCj-CeO-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(x) -(Cj _. -C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) (C ₁ -Ce)-EIlCyI-S(O) _n -,

5) benzyl-S(O)n-,

6) cyano, 7) -COOH,

8) -CO(Cj-C ₆ )-alkyl,

9) -CO ₂ (Ci-C ₆ )-aJkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ , 12) -0(O0)-(Ci-C ₆ )-a]kyl, and

13) -0(C=O)NR ⁸ R ⁹ ;

R ¹¹ Is:

(a) halo, (b) -OH,

(c) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(d) -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(e) -0[(0=0)O _r ] _s aryl,

(f) -O[(C=O)O _r ] _s heteroaryl, (g) (Ci-C ₆ )-alkyl-S(OV,

(h) aryl-(C ₁ -C ₆ )alkyloxy-,

(i) cyano,

0) -NR ⁸ R ⁹ ,

(k) -0(CO)NR ⁸ R ⁹ , (1) -COOH,

(m) -CO(Ci-C ₆ )-alkyl,

(n) -CO ₂ (C ₁ -C ₆ )-alkyl,

(o) -CONR ⁸ R ⁹ ,

(p) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) aryl-(Ci-C ₆ )allcyloxy-,

5) (Ci-C ₄ )-perfluoroalkyl,

6) (C ₂ -C ₆ )-alkenyl, 7) (C ₂ -C ₆ )-alkynyl,

8) (Ci-C ₆ )-alkyloxy,

9) (C ₁ -Ce)-^lCyI-S(O) _n -,

10) cyano,

11) -COOH, 12) -CO(Ci-C ₆ )-alkyl,

13) -CO ₂ (C ₁ -C ₆ )-alkyl,

14) -CONR ⁸ R ⁹ ,

15) -NR ⁸ R ⁹ ,

16) -O(C=O)-(Ci-C ₆ )-alkyl, and 17) -0(C=O)NR ⁸ R ⁹ ,

(q) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH, 3) (Q-CeO-alkyl,

4) aryHQ-C _f Oalkyloxy-,

6) (C ₂ -C ₆ )-alkenyl,

7) (C ₂ -C ₆ )-alkynyl, 8) (Q-C^-alkyloxy,

9) (C ₁ -Ce)-^k ₇ I-S(O) _n -,

10) cyano,

11) -COOH,

12) -COtQ-C^-alkyl, 13) -CO ₂ (C ₁ -Ce)^IlCyI,

14) -CONR ⁸ R ⁹ ,

15) -NR ⁸ R ⁹ ,

16) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

17) -0(C=O)NR ⁸ R ⁹ ,

(r) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-QO-alkyl,

4) aryl-(C _r C ₆ )alkyloxy-,

5) (C i -C ₄ )-perfluoroalkyl,

6) (C ₂ -C ₆ )-alkenyl,

7) (C ₂ -C ₆ )-alkynyl,

8) (d-C ₆ )-alkyloxy,

9) (d-C ₆ )-alkyl-S(O) _n -,

10) cyano,

H) -COOH,

12) -CO(C _r C ₆ )-alkyl,

14) -CONR ⁸ R ⁹ ,

15) -NR ⁸ R ⁹ ,

16) -O(C=O)-(Ci-C ₆ )-alkyl, and

17) -0(C=O)NR ⁸ R ⁹ ,

(s) -(C ₂ -C i _O )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

D halo,

2) -OH,

3) (C _r C ₆ )-alkyloxy

4) (Cj-C ₆ )-alkyl-S(O) _n -,

5) phenyl-(C ₁ -C ₆ )-alkyloxy-,

6) cyano,

7) -CHO,

8) -COOH,

9) -COtQ-OO-alkyl,

10) -CO ₂ (Ci-C ₆ )-alkyl,

11) -CONR ⁸ R ⁹ ,

12) -NR ⁸ R ⁹ ,

13) aryl, 14) heteroaryl as defined above,

15) heterocyclo other than heteroaryl as defined above,

16) -O(C=O)-(Ci-C ₆ )-alkyl, and

17) -0(C=O)NR ⁸ R ⁹ ,

(t) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C _r C ₆ )-alkyloxy,

4) (C _r C ₆ )-alkyl-S(O) _n -, 5) phenyl-(C _r C ₆ )-alkyloxy-,

6) cyano,

7) vinyl,

8) -CHO,

9) -COOH, 10) -CO(Ci-C ₆ )-alkyl,

11) -CO ₂ (Ci-C ₆ )-alkyl,

12) -CONR ⁸ R ⁹ ,

13) -NR ⁸ R ⁹ ,

14) aryl, wherein aryl is defined as above, 15) heteroaryl as defined above,

16) heterocyclyl other than heteroaryl as defined above,

17) -O(C=O)-(Ci-C ₆ )-alkyl, and

18) -0(C=O)NR ⁸ R ⁹ ,

(u) -(Ci-C ₁ o)-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-QO-alkyloxy,

5) benzyl-S(O) _n -,

6) cyano, 7) -COOH,

8) -CO(Ci-C ₆ )-alkyl,

9) -CO ₂ (C ₁ -C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

H) -NR ⁸ R ⁹ , 12) -O(C=O)-(C _r C ₆ )-alltyl, and

13) -0(C=O)NR ⁸ R ⁹ ,

(v) -O(CH ₂ ) _m -heteroaryl as defined above;

R ¹² Is:

(a) halo,

(b) -OH,

(C) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(d) -0[(CO)O _r ] _s (C ₂ ~C ₆ )-alkenyl,

(e) -O[(C=O)O _r ] _s aryl,

(f ⁾ -O[(C=O)O _r ] _s heteroaryl,

(g) (C ₁ -Ce)-^k ₇ I-S(O) _n -,

(h) aryl-^i-C^alkyloxy-,

(i) cyano,

G) nitro,

(k) -NR ⁸ R ⁹ ,

(D -0(CO)NR ⁸ R ⁹ ,

(m) -CHO,

(n) -COOH,

(o) -CO(C _r C ₆ )-alkyl,

(q) -CONR ⁸ R ⁹ ,

(r) aryl, ^■ which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-QO-alkyl,

4) (Q-C^-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Q-OO-alkyl-SCOV,

9) cyano,

10) -COOH,

H) -CO(C _r C ₆ )-alkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(Ci-C ₆ )-aIkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(s) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (Ci-C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkyl-S(O)n-,

9) cyano,

10) -COOH,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ , (t) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl, 4) (Ci-C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (d-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkyl-S(O) _n -, 9) cyano,

10) -COOH,

11) -CO(C _r C ₆ )-alkyl,

12) -CO ₂ (C _r C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ , 14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ , (u) benzyl-S(O) _n -,

(v) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (d-C ₆ )-alkyl-S(O) _n -, 5) cyano,

6) -COOH,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (C ₁ -Ce)-EIlCyI ₅ ^'

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -OCCOHQ-C^-alkyl, and 12) -0(C-O)NR ⁸ R ⁹ ,

(w) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-Cø-alkyloxy,

4) (C ₁ -Ce)-^k ₇ I-S(O) _n -,

5) cyano,

6) -COOH,

7) -CO(C _r C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(CrC ₆ )-alkyl, and

12) -Q(C=O)NR ⁸ R ⁹ ,

(x) -(C ₁ -C ₁ o)-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C _r C ₆ )-alkyloxy,

4) (C _r C ₆ )-alkyl-S(O) _n -,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(d-C ₆ )-alkyl,

9) -CO ₂ (C _r C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

H) -NR ⁸ R ⁹ ,

12) -O(C=O)~(Ci-C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ,

(y) =0;

R ¹⁴ Is:

(a) halo,

(b) -OH ₅

(C) -O[(C=O)O _r ] _s (C _r C ₆ )-alkyl,

(d) -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(e) -O[(C=O)O _r ] _s aryl,

CD -O[(C=O)O _r ] _s heteroaryl,

(g) (d-C^-alkyl-SCOV,

(h) aryl-(Ci-C ₆ )alkyloxy-,

(i) cyano, ω nitro,

CO -NR ⁸ R ⁹ ,

(1) -0(CO)NR ⁸ R ⁹ ,

(m) -CHO,

(n) -COOH,

(o) -CO(Ci-C ₆ )-alkyl,

(P) -CO ₂ (d-C ₆ )-alkyl,

(q) -CONR ⁸ R ⁹ ,

(r) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C^-alkyl,

4) (Ci-C^-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-aIkyl-S(O) _n -,

9) cyano,

10) -COOH,

H) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl, ϊ 13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -0(C=O)-(C ₁ -C ₆ )-;

16) -0(C=O)NR ⁸ R ⁹ ,

(s) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-C^-alkyl,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (C _r C ₆ )-alkyloxy,

8) (C ₁ -C ₆ )-alkyl-S(O) _n -,

9) cyano,

10) -COOH,

H) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -0(O0)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(t) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyϊ.

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (C ₁ -Ce)-EIlCyI-S(O) _n -, 9) cyano,

10) -COOH ₅

11) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ , 14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ , (u) benzyl-S(O) _n -,

(v) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo, T) -OH,

3) (C _r C ₆ )-alkyloxy,

4) (C ₁ -C ₆ )-alkyl-S(O) _n -, 5) cyano,

6) -COOH,

7) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ , 10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(Ci-C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ ,

(w) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (Ci-C ₆ )-alkyl-S(O) _n - ₅

5) cyano,

6) -COOH,

7) -CO(d-C ₆ )-alkyl, 8) -CO ₂ (C _r C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

12) -0(C=O)NR ⁸ R ⁹ , (x) -(Ci-C ₁₀ )-alkyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy, 4) (d-Qø-alkyl-SCOV,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(Ci-C ₆ )-alkyl, 9) -CO^Q-C^-alkyl,

10) -CONR ⁸ R ⁹ ,

11) -NR ⁸ R ⁹ ,

12) -O(C=O)-(Ci-C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ ;

R ¹⁶ and R ¹⁷ are independently:

(a) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo, 2) -OH,

3) (C _r C ₆ )-alkyl,

4) (C _r C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl ₅

7) (C ₁ -C ₆ )-alkyloxy, 9) cyano,

10) -COOH,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ , 14) -NR ⁸ R ⁹ ,

15) -OCC-OHQ-C^-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(b) heteroaryl optionally substituted with one or more substituents selected from the group consisting of: 1) halo,

2) -OH,

3) (d-C ₆ )-alkyl,

4) (C _! -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl, 6) (C ₂ -C ₆ )-alkynyl,

7) (Q-Q-alkyloxy,

8) (d-C^-alkyl-SCOV,

9) cyano,

10) -COOH, 11) -CO(C _r C ₆ )-alkyl,

12) -COzCCi-QO-alkyl.

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C _r C ₆ )-alkyl, and 16) -0(C=O)NR ⁸ R ⁹ ,

(c) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (d-C ₆ )-alkyl,

4) (Q-C^-perfluoroalkyl, 5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

9) cyano, 10) -COOH,

11) -CO(C ₁ -C ₆ HIlCyI,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ , 15) -O(C=O)-(Ci-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(d) (C ₂ -C ₁₀ )-alkenyl, which may optionally be substituted with one or more substituents selected from the group consisting of:

I) halo, 2) -OH,

3) (Ci-C ₆ )-alkyloxy,

5) cyano,

6) -COOH, 7) -CO(C ₁ -C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

I 1) -O(C=O)-(Ci-C ₆ )-alkyl, and 12) -0(C=O)NR ⁸ R ⁹ ,

(e) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C ₁ -C ₆ )-alkyloxy,

4) (C ₁ -Ce)-EIlCyI-S(O) _n -,

> 5) cyano,

6) -COOH,

V) -CO(Ci-C ₆ )-alkyl,

8) -CO ₂ (Ci-C ₆ )-alkyl,

9) -CONR ⁸ R ⁹ ,

) 10) -NR ⁸ R ⁹ ,

H) -O(C=O)-(Ci-C ₆ )-a]kyl. and

12) -0(C=O)NR ⁸ R ⁹ ,

(f) which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (d-C ₆ )-alkyl-S(O) _n -,

5) benzyl-S(O) _n -,

6) cyano,

7) -COOH,

8) -CO(Ci-C ₆ )-alkyl,

9) -CO ₂ (Ci-C ₆ )-alkyl,

10) -CONR ⁸ R ⁹ ,

H) -NR ⁸ R ⁹ ,

12) -O(C=O)-(C _r C ₆ )-alkyl, and

13) -0(C=O)NR ⁸ R ⁹ , or R ¹⁶ and R ¹⁷ are taken together with the nitrogen to which both are attached to form a 3- to 8-membered : ring, which may optionally contain 1-4 heteroatoms selected from

N, O, and S and be optionally substituted with one or more R ¹⁴ 's;

R ¹⁸ is cyano, -COR ¹⁶ Or-SO ₂ R ¹⁶ ;

R ¹⁹ Is:

(a) hydrogen,

(b) (C ₁ -C ₆ )-alkyl, (c) -CO(C ₁ -C ₆ )-alkyl,

(d) -CO(Ci-C ₆ )-aryl,

(e) -CO(Ci-C ₆ )-heteroaryl,

(f) -CO ₂ (C ₁ -C ₆ )-alkyl,

(g) CO ₂ (C ₁ -C ₆ )-aryl, (h) CO ₂ (Ci-C ₆ )-heteroaryl,

(i) -CONR ⁸ R ⁹ ,

Q) -S(O) _n -alkyl,

(k) -S(O) _n -aryl,

(1) -S(O) _n -heteroaryl, or (m) -S(O) _n - NR ⁸ R ⁹ ;

R ²⁰ is independently:

(a) hydrogen,

(b) halo, (c) -OH,

(d) -O[(C=O)O _r ] _s (C ₁ -C ₆ )-alkyl,

(e) -O[(C=O)O _r ] _s (C ₂ -C ₆ )-alkenyl,

(f) -O[(C=O)O _r ] ₈ aiyl,

(g) -O[(C=O)O _r ] _s heteroaryl, (h) (C ₁ -C ₆ )-alkyl-S(O) _n -,

(i) aryl-Cd-C^alkyloxy-,

(j) cyano,

(k) nitro,

(1) -NR ⁸ R ⁹ (m) 0(CO)NR ⁸ R ⁹ ,

(n) -CHO,

(o) COOH,

(p) -CO(C ₁ -C ₆ )-alkyl, (q) -CO ₂ (d-C ₆ )-alkyl, (r) -CONR ⁸ R ⁹ ,

(s) aryl, which may optionally be substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyl,

4) (Ci-C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkyl-S(O) _n -,

9) cyano,

10) -COOH,

H) -CO(C _r C ₆ )-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(d-C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(t) heteroaryl optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (C _r C ₆ )-alkyl,

4) (C _! -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

V) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkyl-S(OV,

9) cyano,

10) -COOH,

11) -CO(Ci-C ₆ )-alkyl,

12) -CO ₂ (C ₁ -C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ , 14) -NR ⁸ R ⁹ ,

15) -0(C=O)-(Ci-C ₆ )-;

16) -Q(C=O)NR ⁸ R ⁹ ,

(u) heterocyclo other than heteroaryl which is optionally substituted with one or more substituents selected from the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyi,

4) (C i -C ₄ )-perfluoroalkyl,

5) (C ₂ -C ₆ )-alkenyl,

6) (C ₂ -C ₆ )-alkynyl,

7) (Ci-C ₆ )-alkyloxy,

8) (Ci-C ₆ )-alkyl-S(O)n-,

9) cyano,

10) -COOH,

H) -COCQ-QO-alkyl,

12) -CO ₂ (Ci-C ₆ )-alkyl,

13) -CONR ⁸ R ⁹ ,

14) -NR ⁸ R ⁹ ,

15) -O(C=O)-(C ₁ -C ₆ )-alkyl, and

16) -0(C=O)NR ⁸ R ⁹ ,

(v) benzyl-S(O) _n -,

(W) (C ₂ -Ci _O )-alkenyl, which may optionally be substituted with one or more substituents selected from, the group consisting of:

1) halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4> (d-C^-alkyl-S^V,

5) cyano,

6) -COOH,

7) -CO(C _r C ₆ )-alkyl,

8) -CO ₂ (C _r C ₆ )-alkyl, 9) -CONR ⁸ R ⁹ ,

10) -NR ⁸ R ⁹ ,

11) -0(C=O)-(C ₁ -C ₆ )-;

12) -0(C-O)NR ⁸ R ⁹ ,

(x) (C ₂ -C ₁₀ )-alkynyl wherein alkynyl is optionally substituted with one or more substituents selected from the group consisting of:

D halo,

2) -OH,

3) (Ci-C ₆ )-alkyloxy,

4) (d-C ₆ )-alkyl-S(O) _n -,