Title:
ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
Document Type and Number:
WIPO Patent Application WO2004009565
Kind Code:
A3
Abstract:
The invention concerns a compound of general formula (I), wherein: R1 represents an optionally substituted C1-6 alkyl, a C3-7 cycloalkyl, a thiophene, a benzothiophene, a pyridinyl, a furanyl or a phenyl; the phenyl groups being optionally substituted; R2 and R'2 represent independently of each other a hydrogen atom, a halogen atom, a hydroxy, a C1-3 alkoxy, a C1-3 alkyl, a C3-7 cycloalkyl, a O-C(O)-C1-6 alkyl group, or R2 and R'2 together form an oxo group; R3 represents a hydrogen atom, a C1-16 alkyl optionally substituted by a hydroxy or a C1-3 alkoxy; R4 and R5 represent, independently of each other a hydrogen atom, an optionally substituted C1-7 alkyl, a C3-7 cycloalkyl, a phenyl, a naphthyl or a -C(X)R6; the C3-7 cycloalkyl and phenyl groups being optionally substituted; provided that at least one R4 or R5 group represents a -C(X)R6 group; X represents an oxygen atom or a sulphur atom; R6 represents a C1-6 alkoxy group, a hydroxy or a -NR7R8 group; the C1-6 alkoxy group being optionally substituted by a phenyl; R7 and R8 represent, independently of each other a hydrogen atom, an optionally substituted C1-6 alkyl group, a C3-7 cycloalkyl, C1-6 alkoxy or a phenyl; or R7 and R8, together with the atom bearing them form an aziridine, azetidine, pyrrolidine, piperidine or morpholine cycle; the C3-7 cycloalkyle and phenyl groups being optionally substituted; in the form of base, addition salt to an acid or hydrate. The invention is applicable in therapeutics.
Inventors:
BALTZER SYLVIE (FR)
SCHOENTJES BRUNO (FR)
VAN DORSSELAER VIVIANE (FR)
SCHOENTJES BRUNO (FR)
VAN DORSSELAER VIVIANE (FR)
Application Number:
PCT/FR2003/002194
Publication Date:
April 08, 2004
Filing Date:
July 11, 2003
Export Citation:
Assignee:
SANOFI SYNTHELABO (FR)
BALTZER SYLVIE (FR)
SCHOENTJES BRUNO (FR)
VAN DORSSELAER VIVIANE (FR)
BALTZER SYLVIE (FR)
SCHOENTJES BRUNO (FR)
VAN DORSSELAER VIVIANE (FR)
International Classes:
C07D277/20; A61K31/426; A61K31/454; A61K31/5377; A61P7/00; A61P9/10; A61P25/16; A61P25/28; C07D277/46; C07D277/56; C07D417/12; (IPC1-7): C07D277/56; C07D417/12; A61K31/426; A61K31/427; A61K31/4439; A61P25/28
Domestic Patent References:
| WO1998022430A1 | 1998-05-28 |
Foreign References:
| US5712270A | 1998-01-27 |
Other References:
HIGAKI J N ET AL: "A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 19, 23 September 1999 (1999-09-23), pages 3889 - 3898, XP002185434
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