Title:
ACYLATED GLP-1 DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/201328
Kind Code:
A1
Abstract:
Provided are a GLP-1 (7-37) polypeptide analog, a fatty acid-modified derivative of the analog, and a drug comprising the derivative. Further, also provided are a preparation method of the derivative and a use of the same in preparing a drug.
Inventors:
XU ZHENG (CN)
LI FENG (CN)
SONG RUI (CN)
GUO WANJUN (CN)
PAN HAI (CN)
LIN ZHAOSHENG (CN)
DENG JIANHUI (CN)
FENG JING (CN)
LI FENG (CN)
SONG RUI (CN)
GUO WANJUN (CN)
PAN HAI (CN)
LIN ZHAOSHENG (CN)
DENG JIANHUI (CN)
FENG JING (CN)
Application Number:
PCT/CN2019/083383
Publication Date:
October 24, 2019
Filing Date:
April 19, 2019
Export Citation:
Assignee:
HANGZHOU SCIWIND BIOSCIENCES CO LTD (CN)
International Classes:
C07K14/605; A61K38/26; A61K47/68; A61P3/10; C07K1/02; C07K1/107; C07K1/30
Domestic Patent References:
| WO2013167454A1 | 2013-11-14 | |||
| WO1996029342A1 | 1996-09-26 | |||
| WO1998008871A1 | 1998-03-05 | |||
| WO1999043708A1 | 1999-09-02 | |||
| WO2000034331A2 | 2000-06-15 | |||
| WO2000069911A1 | 2000-11-23 | |||
| WO2006097537A2 | 2006-09-21 | |||
| WO2002046227A2 | 2002-06-13 |
Foreign References:
| CN107033234A | 2017-08-11 | |||
| CN101133082A | 2008-02-27 | |||
| US5545618A | 1996-08-13 | |||
| US5424686A | 1995-06-13 | |||
| US0692464A | 1902-02-04 | |||
| CN107033234A | 2017-08-11 | |||
| CN101133082A | 2008-02-27 |
Other References:
BELL G. I.SANCHEZ-PESCADOR R.LAYBOURN P. J. ET AL.: "Exon duplication and divergence in the human preproglucagon gene [J", NATURE, vol. 304, no. 5924, 1983, pages 368 - 371, XP001249172, DOI: 10.1038/304368a0
FU GANGGONG MINXU WEIREN: "Research progress of glucagon-like peptide 1 and its receptor agonists [J", TIANJIN MEDICAL JOURNAL, vol. 40, no. 2, 2012, pages 181 - 184
AERTGEERTS KYE STENNANT M, G ET AL.: "Crystal structure of human dipeptidyl peptidase IV in complex with a dipeptide peptidase reveals details on substrate specificity and tetrahedral intermediate [J", PROTEIN SCI., vol. 13, no. 2, 2004, pages 412 - 421, XP002344668, DOI: 10.1110/ps.03460604
SARAUSTE DE MENTHIERECCHAVANIEUA, GRASSYG ET AL.: "Structural requirements of the N-terminal region of GLP-1-[7-37]-NH for receptor interaction and cAMP production [J", EUR J MED CHEM, vol. 39, no. 6, 2004, pages 473 - 480
SAMBROOK, JFRITSCH, EFMANIATIS, T: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3783014A4
FU GANGGONG MINXU WEIREN: "Research progress of glucagon-like peptide 1 and its receptor agonists [J", TIANJIN MEDICAL JOURNAL, vol. 40, no. 2, 2012, pages 181 - 184
AERTGEERTS KYE STENNANT M, G ET AL.: "Crystal structure of human dipeptidyl peptidase IV in complex with a dipeptide peptidase reveals details on substrate specificity and tetrahedral intermediate [J", PROTEIN SCI., vol. 13, no. 2, 2004, pages 412 - 421, XP002344668, DOI: 10.1110/ps.03460604
SARAUSTE DE MENTHIERECCHAVANIEUA, GRASSYG ET AL.: "Structural requirements of the N-terminal region of GLP-1-[7-37]-NH for receptor interaction and cAMP production [J", EUR J MED CHEM, vol. 39, no. 6, 2004, pages 473 - 480
SAMBROOK, JFRITSCH, EFMANIATIS, T: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3783014A4
Attorney, Agent or Firm:
BEI JING CAI HE LAW FIRM (CN)
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