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Title:
ACYLOXYALKYL CARBAMATE PRODRUGS OF SULFINIC ACIDS, METHODS OF SYNTHESIS, AND USE
Document Type and Number:
WIPO Patent Application WO2006050471
Kind Code:
A3
Abstract:
Acyloxyalkyl carbamate prodrugs of 3-aminopropylsulfinic acid and analogs thereof, pharmaceutical compositions of 3-aminopropylsulfinic acid and analogs thereof, methods of making prodrugs of 3-aminopropylsulfinic acid and analogs thereof, methods of using prodrugs of 3-aminopropylsulfinic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing diseases or disorders such as spasticity or gastroesophageal reflux disease are disclosed. Acyloxyalkyl carbamate prodrugs of 3­-aminopropylsulfinic acid and analogs thereof and sustained release oral dosage forms thereof, which are suitable for oral administration, are also disclosed.

Inventors:
GALLOP MARK (US)
Application Number:
PCT/US2005/039871
Publication Date:
July 13, 2006
Filing Date:
November 03, 2005
Export Citation:
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Assignee:
XENOPORT INC (US)
GALLOP MARK (US)
International Classes:
C07C313/04; A61K31/185
Domestic Patent References:
WO2002100823A12002-12-19
WO2002100347A22002-12-19
WO2004000855A12003-12-31
WO2004000856A12003-12-31
Foreign References:
US6117908A2000-09-12
US20030162754A12003-08-28
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