Title:
ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2003/014062
Kind Code:
A1
Abstract:
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
Inventors:
INMAN JOHN K (US)
GOEL ATUL (IN)
APPELLA ETTORE (US)
TURPIN JIM A (US)
GOEL ATUL (IN)
APPELLA ETTORE (US)
TURPIN JIM A (US)
Application Number:
PCT/US2002/023924
Publication Date:
February 20, 2003
Filing Date:
July 25, 2002
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
INMAN JOHN K (US)
GOEL ATUL (IN)
APPELLA ETTORE (US)
TURPIN JIM A (US)
SCHITO MARCO (US)
INMAN JOHN K (US)
GOEL ATUL (IN)
APPELLA ETTORE (US)
TURPIN JIM A (US)
SCHITO MARCO (US)
International Classes:
C07C323/62; C07C329/10; C07C329/20; C07C333/08; C07C333/24; C07D213/06; C07D213/20; (IPC1-7): C07C233/05; C07C233/65; C07D213/06; A61K31/16; A61K31/21; A61K31/44
Domestic Patent References:
| WO1999065871A2 | 1999-12-23 |
Foreign References:
| US6046228A | 2000-04-04 |
Other References:
LANGE, AIDS, vol. 10, no. 1, 1996, pages S27 - S30
BIRCH, AIDS, vol. 12, 1998, pages 680 - 681
ROBERTS, AIDS, vol. 12, 1998, pages 453 - 460
YANG, LEUKEMIA, vol. 11, no. 3, 1997, pages 8992
DEMETER, J. ACQUIR. IMMUNE DEFIC. SYNDR. HUM. RETROVIROL., vol. 14, no. 2, 1997, pages 136 - 144
KURITZKES, AIDS, vol. 10, no. 5, 1996, pages S27 - S31
AMARA ET AL., SCIENCE, vol. 291, 2001, pages 1879 - 1881
HAYNES, IMMUNOL. RES., vol. 22, 2001, pages 263 - 269
BOLOGNESI, NATURE, vol. 391, 1998, pages 638 - 639
BANGHAM, LANCET, vol. 350, 1997, pages 1617 - 1621
GOEL ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 767 - 770
SONG ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 1263 - 1273
HENDERSON, J. VIROL., vol. 66, 1992, pages 1856
ALDOVINI, J. VIROL., vol. 64, 1990, pages 1920
GORELICK, J. VIROL., vol. 64, 1990, pages 3207
GOUGH, J. ANAER. CHEM. SOC., vol. 124, 2002, pages 3885 - 3892
FEHRMANN, VIROLOGY, vol. 235, 1997, pages 352 - 359
JACKS, NATURE, vol. 331, 1988, pages 280 - 283
HUMPHREY: "Antimicrob", AGENTS & CHEMOTHERAPY, vol. 41, 1997, pages 1017 - 1023
KARACOSTAS, VIROLOGY, vol. 193, 1993, pages 661 - 671
HUANG, J VIROL., vol. 71, 1997, pages 4378 - 4384
LAPADAT-TAPOLSKY, J. MOL. BIOL., vol. 268, 1997, pages 250 - 260
DEMENE, BIOCHEMISTRY, vol. 33, 1994, pages 11707 - 11716
P. K. VOGT: "Retroviruses", 1997, COLD SPRING HARBOR LABORATORY PRESS, article "Historical introduction to the general properties of retroviruses", pages: 1 - 26
"Archives of Virology", vol. 10, 1995, SPRINGER VERLAG, pages: 586
BIOORG MED. CHEM., vol. 10, 2002, pages 1263 - 73
J. MED. CHEM., vol. 42, 1999, pages 67 - 86
PETER WUT'S; THEODORA GREENE'S: "Protective Groups in Organic Synthesis", 1999
EDWARDS, SCIENCE, vol. 276, 1997, pages 18681871
"Remington's Pharmaceutical Sciences"
HASHIDA, J. CLIN. LAB. ANAL., vol. 11, 1997, pages 267 - 286
FLO, EUR. J. CLIN. MICROBIOL. INFECT. DIS., vol. 14, 1995, pages 504 - 511
YAMASHITA, J. MOL. BIOL., vol. 278, 1998, pages 609 - 615
WU, BIOCHEMISTRY, vol. 37, 1998, pages 4518 - 4526
"Theory and Practice", 1992, ACADEMIC PRESS, INC, article "Capillary Electrophoresis"
BESS, J. VIROL., vol. 66, 1992, pages 840
SUMMERS, PROTEIN SCIENCE, vol. 1, 1992, pages 563
RICE, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 9721
TURPIN, J. VIROL., vol. 70, 1996, pages 6180
WEISLOW, J. NATL. CANCER INST., vol. 81, 1993, pages 577
SUMMERS, PROTEIN SCIENCE, vol. 1, 1992, pages 563 - 567
RICE, NATURE, vol. 361, 1993, pages 473 - 475
MCDONNELL, J. MED. CHEM., vol. 40, 1997, pages 1969
RICE, NATURE MEDICINE, vol. 3, 1997, pages 341 - 345
TOLCUNAGA, J. VIROL., vol. 72, 1998, pages 6257 - 6259
RICE, PNAS, vol. 90, 1993, pages 9721 - 9724
RICE: "Antimicrob", AGENTS CHEMOTHER., vol. 41, 1997, pages 419 - 426
LU, CRIT. REV. ONCOL., vol. 8, 1997, pages 273 - 291
NEILDEZ, VIROLOGY, vol. 243, 1998, pages 12 - 20
GERETTI, J. GEN VIROL, vol. 79, 1998, pages 415 - 421
MOHRI, SCIENCE, vol. 279, 1998, pages 1223 - 1227
LEE, PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 939 - 944
SCHWIEBERT, AIDS RES & HUM. RETROVIRUSES, vol. 14, 1998, pages 269 - 274
RICE, ANTIMICROB. AGENTS & CHEMOTHER, vol. 41, 1997, pages 419 - 426
BUCLCHEIT, AIDS RES. & HUMAN RETROVIRUSES, vol. 10, 1994, pages 1497 - 1506
TURPIN, ANTIMICROB. AGENTS & CHEMOTHER, vol. 42, 1998, pages 487 - 494
See also references of EP 1425262A4
BIRCH, AIDS, vol. 12, 1998, pages 680 - 681
ROBERTS, AIDS, vol. 12, 1998, pages 453 - 460
YANG, LEUKEMIA, vol. 11, no. 3, 1997, pages 8992
DEMETER, J. ACQUIR. IMMUNE DEFIC. SYNDR. HUM. RETROVIROL., vol. 14, no. 2, 1997, pages 136 - 144
KURITZKES, AIDS, vol. 10, no. 5, 1996, pages S27 - S31
AMARA ET AL., SCIENCE, vol. 291, 2001, pages 1879 - 1881
HAYNES, IMMUNOL. RES., vol. 22, 2001, pages 263 - 269
BOLOGNESI, NATURE, vol. 391, 1998, pages 638 - 639
BANGHAM, LANCET, vol. 350, 1997, pages 1617 - 1621
GOEL ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 767 - 770
SONG ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 1263 - 1273
HENDERSON, J. VIROL., vol. 66, 1992, pages 1856
ALDOVINI, J. VIROL., vol. 64, 1990, pages 1920
GORELICK, J. VIROL., vol. 64, 1990, pages 3207
GOUGH, J. ANAER. CHEM. SOC., vol. 124, 2002, pages 3885 - 3892
FEHRMANN, VIROLOGY, vol. 235, 1997, pages 352 - 359
JACKS, NATURE, vol. 331, 1988, pages 280 - 283
HUMPHREY: "Antimicrob", AGENTS & CHEMOTHERAPY, vol. 41, 1997, pages 1017 - 1023
KARACOSTAS, VIROLOGY, vol. 193, 1993, pages 661 - 671
HUANG, J VIROL., vol. 71, 1997, pages 4378 - 4384
LAPADAT-TAPOLSKY, J. MOL. BIOL., vol. 268, 1997, pages 250 - 260
DEMENE, BIOCHEMISTRY, vol. 33, 1994, pages 11707 - 11716
P. K. VOGT: "Retroviruses", 1997, COLD SPRING HARBOR LABORATORY PRESS, article "Historical introduction to the general properties of retroviruses", pages: 1 - 26
"Archives of Virology", vol. 10, 1995, SPRINGER VERLAG, pages: 586
BIOORG MED. CHEM., vol. 10, 2002, pages 1263 - 73
J. MED. CHEM., vol. 42, 1999, pages 67 - 86
PETER WUT'S; THEODORA GREENE'S: "Protective Groups in Organic Synthesis", 1999
EDWARDS, SCIENCE, vol. 276, 1997, pages 18681871
"Remington's Pharmaceutical Sciences"
HASHIDA, J. CLIN. LAB. ANAL., vol. 11, 1997, pages 267 - 286
FLO, EUR. J. CLIN. MICROBIOL. INFECT. DIS., vol. 14, 1995, pages 504 - 511
YAMASHITA, J. MOL. BIOL., vol. 278, 1998, pages 609 - 615
WU, BIOCHEMISTRY, vol. 37, 1998, pages 4518 - 4526
"Theory and Practice", 1992, ACADEMIC PRESS, INC, article "Capillary Electrophoresis"
BESS, J. VIROL., vol. 66, 1992, pages 840
SUMMERS, PROTEIN SCIENCE, vol. 1, 1992, pages 563
RICE, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 9721
TURPIN, J. VIROL., vol. 70, 1996, pages 6180
WEISLOW, J. NATL. CANCER INST., vol. 81, 1993, pages 577
SUMMERS, PROTEIN SCIENCE, vol. 1, 1992, pages 563 - 567
RICE, NATURE, vol. 361, 1993, pages 473 - 475
MCDONNELL, J. MED. CHEM., vol. 40, 1997, pages 1969
RICE, NATURE MEDICINE, vol. 3, 1997, pages 341 - 345
TOLCUNAGA, J. VIROL., vol. 72, 1998, pages 6257 - 6259
RICE, PNAS, vol. 90, 1993, pages 9721 - 9724
RICE: "Antimicrob", AGENTS CHEMOTHER., vol. 41, 1997, pages 419 - 426
LU, CRIT. REV. ONCOL., vol. 8, 1997, pages 273 - 291
NEILDEZ, VIROLOGY, vol. 243, 1998, pages 12 - 20
GERETTI, J. GEN VIROL, vol. 79, 1998, pages 415 - 421
MOHRI, SCIENCE, vol. 279, 1998, pages 1223 - 1227
LEE, PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 939 - 944
SCHWIEBERT, AIDS RES & HUM. RETROVIRUSES, vol. 14, 1998, pages 269 - 274
RICE, ANTIMICROB. AGENTS & CHEMOTHER, vol. 41, 1997, pages 419 - 426
BUCLCHEIT, AIDS RES. & HUMAN RETROVIRUSES, vol. 10, 1994, pages 1497 - 1506
TURPIN, ANTIMICROB. AGENTS & CHEMOTHER, vol. 42, 1998, pages 487 - 494
See also references of EP 1425262A4
Attorney, Agent or Firm:
Snyder, Joseph R. (Two Embarcadero Center Eighth Floo, San Francisco CA, US)
Weber, Kenneth A. (8th Floor 2 Embarcadero Cente, San Francisco CA, US)
Weber, Kenneth A. (8th Floor 2 Embarcadero Cente, San Francisco CA, US)
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