ADAMANTYL DERIVATIVES AS ANTI-CANCER AGENTS

WIPO Patent Application WO2001056563

A9

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and/or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-[3-(1-adamantyl)- 4-methoxyphenyl]-2-naphthoic acid, 2-[3-(1-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid, and 6-[3-(1-adamantyl)-4,5-methylenedioxyphenyl]-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

PFAHL MAGNUS (US)
LU XIAN-PING (US)
RIDEOUT DARRYL (US)
ZHANG HONGYUE (US)

PCT/US2001/003717

October 31, 2002

February 05, 2001

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GALDERMA RES & DEV (FR)
PFAHL MAGNUS (US)
LU XIAN-PING (US)
RIDEOUT DARRYL (US)
ZHANG HONGYUE (US)

C07D243/08; A61K9/06; A61K31/05; A61K31/07; A61K31/192; A61K31/222; A61K31/235; A61K31/34; A61K31/343; A61K31/35; A61K31/352; A61K31/357; A61K31/36; A61K31/38; A61K31/385; A61K31/4166; A61K31/4184; A61K31/495; A61K31/496; A61K31/5375; A61K31/551; A61K31/7008; A61K45/00; A61P35/00; A61P43/00; C07D235/12; C07D295/10; C07D307/80; C07D317/60; C07D493/08; C07H7/033; (IPC1-7): A61K31/235; A61K31/34; A61K31/35; A61K31/38; A61K31/385

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