Title:
ADAPTER FOR UNIVERSAL TUMOR TARGETING
Document Type and Number:
WIPO Patent Application WO/2024/055023
Kind Code:
A3
Abstract:
Compositions and methods are provided that enhance CAR T-cell therapy by providing an oncolytic virus engineered to direct expression and secretion of a multivalent adapter protein. The multivalent adapter protein targets both a broadly tumor-associated cell surface antigen and an antigen binding domain of a CAR T-cell.
Inventors:
LIU XIAOHU (CA)
MURAD YANAL (CA)
LEE I-FANG (CA)
JIA WILLIAM (CA)
MURAD YANAL (CA)
LEE I-FANG (CA)
JIA WILLIAM (CA)
Application Number:
PCT/US2023/073811
Publication Date:
May 02, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
VIROGIN BIOTECH CANADA LTD (CA)
International Classes:
A61K35/763; A61P35/00; C07K16/28; C12N15/86
Attorney, Agent or Firm:
MCMASTERS, David, D. (US)
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