Title:
ADJUVANT FORMULATIONS FOR BACTERIAL AND VIRUS VACCINES AND METHOD OF MAKING SAME
Document Type and Number:
WIPO Patent Application WO2003049670
Kind Code:
A3
Abstract:
A pharmaceutical composition including an adjuvant effective amount of a protected inosine monophosphate (IMP) compound. The pharmaceutical composition includes the protected IMP compound alone, or in combination with vaccine agents with or without additional adjuvants. The pharmaceutical composition can be utilized as a vaccine composition or can be included with existing vaccine compositions in order to increase a specific T lymphocyte mediated immune response thereto. Various methods relating to the pharmaceutical composition and the vaccine are described herein. The vaccines can be employed to prevent or treat infections. Additionally, the pharmaceutical compositions not only increase T-cell responses, but also confer, by pretreatment, nonspecific protection against a variety of pathogens. This combination of actions is appropriate for enhancing defense against bioterrorism with organisms like smallpox or anthrax.
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Inventors:
HADDEN JOHN (US)
NAYLOR PAUL H (US)
SIGNORELLI KATHY L
NAYLOR PAUL H (US)
SIGNORELLI KATHY L
Application Number:
PCT/US2002/023765
Publication Date:
November 06, 2003
Filing Date:
July 26, 2002
Export Citation:
Assignee:
IMMUNO RX INC (US)
HADDEN JOHN (US)
NAYLOR PAUL H (US)
SIGNORELLI KATHY L
HADDEN JOHN (US)
NAYLOR PAUL H (US)
SIGNORELLI KATHY L
International Classes:
A61K39/39; (IPC1-7): A61K31/70
Other References:
SOSA ET AL.: "Immunopharmagologic properties of inosine 5'-methyl monophosphate", ANN. NY ACADEMY SCI., vol. 685, 23 June 1993 (1993-06-23), pages 458 - 463, XP002953251
HADDEN J.W. ET AL.: "Methyl inosine monophosphate (MIMP), a new purine immunomodulator for HIV infection", INT. J. IMMUNOPHARMACOLOGY, vol. 13, 1991, pages 49 - 54, XP002953252
NATARAJAN R.: "Synthesis and biological properties of purine and pyrimidine 5'-deoxy-5'(dihydroxyphosphinyl)-beta-D-ribofuranosyl analogues of AMP, GMP, IMP and CMP", J. MED. CHEM., vol. 32, no. 6, 1989, pages 1307 - 1313, XP002953253
SZABADOS E.: "Inosine-5'-monophosphate analogues as inhibitors off human IMP cyclohydrolase and cellular growth", vol. 44, no. 3, March 1998 (1998-03-01), pages 617 - 623, XP002953255
THOMPSON L.: "Inosine 5'-monophosphate vs inosine and hypoxanthine as substrates for purine salvage in human lymphoid cells", vol. 179, 1985, pages 432 - 436, XP002953254
HADDEN J.W. ET AL.: "Methyl inosine monophosphate (MIMP), a new purine immunomodulator for HIV infection", INT. J. IMMUNOPHARMACOLOGY, vol. 13, 1991, pages 49 - 54, XP002953252
NATARAJAN R.: "Synthesis and biological properties of purine and pyrimidine 5'-deoxy-5'(dihydroxyphosphinyl)-beta-D-ribofuranosyl analogues of AMP, GMP, IMP and CMP", J. MED. CHEM., vol. 32, no. 6, 1989, pages 1307 - 1313, XP002953253
SZABADOS E.: "Inosine-5'-monophosphate analogues as inhibitors off human IMP cyclohydrolase and cellular growth", vol. 44, no. 3, March 1998 (1998-03-01), pages 617 - 623, XP002953255
THOMPSON L.: "Inosine 5'-monophosphate vs inosine and hypoxanthine as substrates for purine salvage in human lymphoid cells", vol. 179, 1985, pages 432 - 436, XP002953254
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