ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS

Title:

ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS

Document Type and Number:

WIPO Patent Application WO2003015704

Kind Code:

A3

Abstract:

Methods are provided for preventing or treating risk factors for cardiovascular disease in an individual, comprising administering a therapeutically effective amount of a composition comprising an estradiol metabolite to said individual. Such risk factors include obesity, the metabolic syndrome, diabetes mellitus, vascular disorders, and renal disorders. Preferred estradiol metabolites include 2-methoxyestradiol, 4- methoxyestradiol, 2-hydroxyestradiol, and 4-hydroxyestradiol or prodrugs thereof. The compositions may also be in the form of a controlled release formulation. Methods are also provided for use of estradiol metabolites to treat or prevent insulin resistance, vascular endothelial dysfunction, hyperlipidemia, hypertension, diabetic nephropathy, proteinuria and reducing leptin levels. In addition, the methods provide a method of stabilizing glucose levels. These treatments may be used in either gender because of their lack of a feminizing estrogenic effect.

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Inventors:

JACKSON EDWIN K (US)
TOFOVIC STEVAN P (US)
DUBEY RAGHVENDRA K (US)

Application Number:

PCT/US2002/026253

Publication Date:

March 18, 2004

Filing Date:

August 19, 2002

Export Citation:

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Assignee:

UNIV PITTSBURGH (US)
JACKSON EDWIN K (US)
TOFOVIC STEVAN P (US)
DUBEY RAGHVENDRA K (US)

International Classes:

A61K31/565; A61P3/00; A61P3/04; A61P3/10; A61P3/12; A61P9/00; A61P9/10; A61P13/00; A61P13/12; A61P43/00; (IPC1-7): A61K31/56

Foreign References:

US5977096A

1999-11-02

Other References:

DATABASE MEDLINE [online] DUBEY ET AL.: "17beta-Estradiol, its metabolites and progesterone inhibit cardiac fibroblast growth", XP002973718, Database accession no. 9453356
See also references of EP 1418876A4

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