Title:
ADP-RIBOSE BINDING PEPTIDE HAVING ANTICANCER ACTIVITY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/033481
Kind Code:
A1
Abstract:
The present invention relates to an adenosine diphosphate-ribose (ADP-ribose) binding peptide having anticancer activity and, more particularly, to an ADP-ribose binding peptide of a specific amino acid sequence, a modified product thereof, and a cancer preventing or treating pharmaceutical composition and an anticancer-adjuvant pharmaceutical composition comprising same as an active ingredient. The ADP-ribose binding peptide of the present invention induces cancer cell death by accumulating ADP-ribose in cancer cells and destroying the balance of cells while having an excellent anticancer effect without toxicity to normal cells, and, when concomitantly administered with other anticancer drugs or an anticancer radiotherapy, has an excellent effect as an anticancer adjuvant by increasing the reactivity to the anticancer drugs and the anticancer radiotherapy.
Inventors:
JEONG KEUN-YEONG (KR)
PARK MIN HEE (KR)
PARK MIN HEE (KR)
Application Number:
PCT/KR2022/012886
Publication Date:
March 09, 2023
Filing Date:
August 29, 2022
Export Citation:
Assignee:
JEONG KEUN YEONG (KR)
PARK MIN HEE (KR)
PARK MIN HEE (KR)
International Classes:
C07K14/00; A61K38/00; A61P35/00; C07H19/207
Foreign References:
| US20200384118A1 | 2020-12-10 |
Other References:
WANG ZHIZHI, MICHAUD GREGORY A., CHENG ZHIHONG, ZHANG YUE, HINDS THOMAS R., FAN ERKANG, CONG FENG, XU WENQING: "Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination", GENES & DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY., US, vol. 26, no. 3, 1 February 2012 (2012-02-01), US , pages 235 - 240, XP093042868, ISSN: 0890-9369, DOI: 10.1101/gad.182618.111
KOO JA-HYUN, YOON HEESEOK, KIM WON-JU, CHA DONGHUN, CHOI JE-MIN: "Cell-Penetrating Function of the Poly(ADP-Ribose) (PAR)-Binding Motif Derived from the PAR-Dependent E3 Ubiquitin Ligase Iduna", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 3, 8 March 2018 (2018-03-08), pages 779, XP093042870, DOI: 10.3390/ijms19030779
KRIETSCH JANA, ROULEAU MICHÈLE, PIC ÉMILIE, ETHIER CHANTAL, DAWSON TED M., DAWSON VALINA L., MASSON JEAN-YVES, POIRIER GUY G., GAG: "Reprogramming cellular events by poly(ADP-ribose)-binding proteins", MOLECULAR ASPECTS OF MEDICINE, PERGAMON PRESS, OXFORD., GB, vol. 34, no. 6, 1 December 2013 (2013-12-01), GB , pages 1066 - 1087, XP093042872, ISSN: 0098-2997, DOI: 10.1016/j.mam.2012.12.005
PALAZZO LUCA, AHEL IVAN: "PARPs in genome stability and signal transduction: implications for cancer therapy", BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, GB, vol. 46, no. 6, 17 December 2018 (2018-12-17), GB , pages 1681 - 1695, XP093042873, ISSN: 0300-5127, DOI: 10.1042/BST20180418
JUAN ET AL., CANCERS, vol. 12, no. 3, 2020, pages 739
J MATEO ET AL., ANN ONCOL., vol. 30, no. 9, 2019, pages 1437
REBECCA GUPTE ET AL., GENES DEV, vol. 31, no. 2, 2017, pages 101
L. ARAVIND: "TRENDS", BIOCHEMICAL SCIENCES, vol. 26, no. 5, 2001, pages 273
PNAS, vol. 108, no. 34, 23 August 2011 (2011-08-23), pages 14103 - 14108
J. SAMBROOK ET AL.: "A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
F.M. AUSUBEL ET AL.: "Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.
KOO JA-HYUN, YOON HEESEOK, KIM WON-JU, CHA DONGHUN, CHOI JE-MIN: "Cell-Penetrating Function of the Poly(ADP-Ribose) (PAR)-Binding Motif Derived from the PAR-Dependent E3 Ubiquitin Ligase Iduna", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 3, 8 March 2018 (2018-03-08), pages 779, XP093042870, DOI: 10.3390/ijms19030779
KRIETSCH JANA, ROULEAU MICHÈLE, PIC ÉMILIE, ETHIER CHANTAL, DAWSON TED M., DAWSON VALINA L., MASSON JEAN-YVES, POIRIER GUY G., GAG: "Reprogramming cellular events by poly(ADP-ribose)-binding proteins", MOLECULAR ASPECTS OF MEDICINE, PERGAMON PRESS, OXFORD., GB, vol. 34, no. 6, 1 December 2013 (2013-12-01), GB , pages 1066 - 1087, XP093042872, ISSN: 0098-2997, DOI: 10.1016/j.mam.2012.12.005
PALAZZO LUCA, AHEL IVAN: "PARPs in genome stability and signal transduction: implications for cancer therapy", BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, GB, vol. 46, no. 6, 17 December 2018 (2018-12-17), GB , pages 1681 - 1695, XP093042873, ISSN: 0300-5127, DOI: 10.1042/BST20180418
JUAN ET AL., CANCERS, vol. 12, no. 3, 2020, pages 739
J MATEO ET AL., ANN ONCOL., vol. 30, no. 9, 2019, pages 1437
REBECCA GUPTE ET AL., GENES DEV, vol. 31, no. 2, 2017, pages 101
L. ARAVIND: "TRENDS", BIOCHEMICAL SCIENCES, vol. 26, no. 5, 2001, pages 273
PNAS, vol. 108, no. 34, 23 August 2011 (2011-08-23), pages 14103 - 14108
J. SAMBROOK ET AL.: "A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
F.M. AUSUBEL ET AL.: "Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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