Title:
AFFINITY ENHANCEMENT AGENTS
Document Type and Number:
WIPO Patent Application WO2003033653
Kind Code:
B1
Abstract:
This invention relates to a kit containing a multivalent, multi-specific binding protein and a carrier molecule. The binding protein has two or more binding sites where at least one binding site binds with a hapten moiety and at least one site binds with a target antigen. The carrier molecule contains a linking molecule that bears a diagnostic agent and/or a therapeutic agent and two or more haptens. The present invention further relates to bispecific diabodies that bind with hapten moieties and target antigens and to recombinant vectors useful for the expression of these functional diabodies in a microbial host.
Inventors:
CHANG CHIEN-HSING KEN (US)
ROSSI EDMUND (US)
ROSSI EDMUND (US)
Application Number:
PCT/US2002/032717
Publication Date:
February 12, 2004
Filing Date:
October 15, 2002
Export Citation:
Assignee:
IMMUNOMEDICS INC (US)
CHANG CHIEN-HSING KEN (US)
ROSSI EDMUND (US)
IBC PHARMACEUTICALS (US)
CHANG CHIEN-HSING KEN (US)
ROSSI EDMUND (US)
IBC PHARMACEUTICALS (US)
International Classes:
A61K38/00; A61K38/02; A61K38/22; A61K39/395; A61K45/00; C12N15/09; A61K45/06; A61K47/42; A61K47/48; A61P9/00; A61P29/00; A61P31/00; A61P35/00; A61P37/06; C07K2/00; C07K16/18; C07K16/30; C07K16/32; C07K16/44; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/68; (IPC1-7): C07K16/00; A61K39/395; C12N15/00; C12N15/85; C12N15/86
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