Title:
THERAPEUTIC/PREVENTIVE AGENT CONTAINING COUMARIN DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2015/141775
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an agent for the prevention or treatment of inflammatory disease or degenerative disc disease. A coumarin derivative or a pharmaceutically acceptable salt or hydrate thereof that is the active ingredient of this preventive or therapeutic agent shows an exceptional inhibitory effect in pharmacological tests using, as an indicator, the production of fibrosis-related factors and inflammation-related factors such as inflammatory cytokines and the like. This compound also shows an exceptional inhibitory effect in pulmonary-fibrosis-model animals and degenerative-disc-disease-model animals. Therefore, the present invention is extremely useful as a preventive or therapeutic agent for inflammatory disease and degenerative disc disease.
Inventors:
NAIKI MITSURU (JP)
NUMAZAWA TAKUMI (JP)
FUJISAWA HIROKI (JP)
NUMAZAWA TAKUMI (JP)
FUJISAWA HIROKI (JP)
Application Number:
PCT/JP2015/058237
Publication Date:
September 24, 2015
Filing Date:
March 19, 2015
Export Citation:
Assignee:
NIPPON ZOKI PHARMACEUTICAL CO (JP)
International Classes:
A61K31/37; A61P11/00; A61P19/02; A61P29/00; C07D311/18; C07D405/12; C07D409/12
Domestic Patent References:
| WO2014046224A1 | 2014-03-27 |
Foreign References:
| JP2008505064A | 2008-02-21 | |||
| JP2008526951A | 2008-07-24 |
Other References:
See also references of EP 3120848A4
Attorney, Agent or Firm:
FUJII, Ikuro et al. (JP)
Fujii Ikuro (JP)
Fujii Ikuro (JP)
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