Title:
AGENT FOR DETECTING STRUCTURALLY ABNORMAL PROTEIN AND AGENT FOR REDUCING STRUCTURALLY ABNORMAL PROTEIN
Document Type and Number:
WIPO Patent Application WO/2024/029535
Kind Code:
A1
Abstract:
The present invention provides a polypeptide that specifically recognizes a structurally abnormal protein caused by misfolding, etc. in mammals, and a detection agent and a reduction agent for a structurally abnormal protein with the use of the polypeptide. The present invention relates to: an agent for detecting a structurally abnormal protein that contains, as an active ingredient, a polypeptide having a binding site for the structurally abnormal protein, said polypeptide comprising an amino acid sequence represented by SEQ ID NO: 2, or said polypeptide comprising an amino acid sequence having 90% or more sequence identity with the aforesaid amino acid sequence and having a binding activity for the structurally abnormal protein; and an agent for reducing a structurally abnormal protein that contains, as an active ingredient, a polypeptide having the binding site for the structurally abnormal protein and a ubiquitin ligase active site.
Inventors:
NAKANISHI MAKOTO (JP)
JOHMURA YOSHIKAZU (JP)
JOHMURA YOSHIKAZU (JP)
Application Number:
PCT/JP2023/028159
Publication Date:
February 08, 2024
Filing Date:
August 01, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A01K67/027; C12N15/54; A61K31/7088; A61K38/16; A61K38/53; A61K48/00; A61P21/00; A61P25/00; A61P25/02; A61P43/00; C12N5/07; C12N9/10; C12N15/10; C12N15/12; C12N15/53; C12Q1/68; G01N33/68
Foreign References:
| US20200199576A1 | 2020-06-25 | |||
| US20160265057A1 | 2016-09-15 | |||
| JP2021511053A | 2021-05-06 |
Other References:
AMED研究開発課題データベース, 21 May 2022
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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