Title:
AGENT HAVING ANTIOBESITY ACTIVITY AND METHOD OF INHIBITING OBESITY
Document Type and Number:
WIPO Patent Application WO/2006/126325
Kind Code:
A1
Abstract:
[PROBLEMS] Although fucoxanthin extracted from wakame (Undaria pinnatifida) is efficacious as an agent having an antiobesity activity, fucoxanthin is contained in only a small amount in a matured brown alga body and, therefore, it takes a long time and a large cost to obtain a practically usable amount of fucoxanthin. Moreover, it has been required to develop an agent having an enhanced antiobesity activity. Thus, it is intended to specify a carotenoid having a stronger antiobesity activity than fucoxanthin and provide an agent having an antiobesity activity and a method of inhibiting obesity by using the same. [MEANS FOR SOLVING PROBLEMS] As the results of intensive studies for finding a carotenoid having a stronger antiobesity activity than fucoxanthin and a material for economically obtaining the same, it is found out that these problems can be solved by using ascidian. Ascidian is a general name involving marine animals belonging to the phylum Chordata, the subphylum Urochordata, and the class Ascidiacea and these animals widely occur throughout the country. Fucoxanthinol is extracted from, in particular, the internal organs and shell of ascidian and it is clarified that this substance has a strong antiobesity activity.
Inventors:
MIYASHITA KAZUO (JP)
HOSOKAWA MASASHI (JP)
SASHIMA TOKUTAKE (JP)
HOSOKAWA MASASHI (JP)
SASHIMA TOKUTAKE (JP)
Application Number:
PCT/JP2006/305239
Publication Date:
November 30, 2006
Filing Date:
March 16, 2006
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
MIYASHITA KAZUO (JP)
HOSOKAWA MASASHI (JP)
SASHIMA TOKUTAKE (JP)
MIYASHITA KAZUO (JP)
HOSOKAWA MASASHI (JP)
SASHIMA TOKUTAKE (JP)
International Classes:
A61K31/336; A23L33/10; A61K8/97; A61K8/9711; A61K8/98; A61K35/56; A61K35/655; A61K36/02; A61K36/03; A61P3/04; C05G3/00; C07C403/24; C07D303/14; C07D303/32; C09K15/06
Foreign References:
| JP2004075634A | 2004-03-11 | |||
| US20050014219A1 | 2005-01-20 |
Other References:
MAEDA H. ET AL: "Fuxocanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 332, 6 May 2005 (2005-05-06), pages 392 - 397, XP004902490
HOSOKAWA M. ET AL: "Kaiso Shishitsu no Shirarezaru Kenko Kino, Kasso Fucoxanthin ni Shibo Chikuseki Yokuse nado no Kino", KAGAKU TO SEIBUTSU, vol. 43, no. 3, March 2005 (2005-03-01), pages 150 - 152, XP003006019
KONISHI I. ET AL: "Gan Saibo ni Apoptosis o Yudo suru Ascidian Carotenoid no Tanri to Kino Kaiseki", NIPPON SUISAN GAKKAI KOEN YOSISHU, vol. 2005, April 2005 (2005-04-01), pages 128, XP003006020
MASASHI HOSOKAWA ET AL.: "Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPAR y ligand troglitazone, on colon cancer cells", BIOCHIMICA, ET BIOPHYSICAACTA, vol. 1675, 2004, pages 113 - 119, XP004630326, DOI: doi:10.1016/j.bbagen.2004.08.012
TAKAAKI KONNO ET AL.: "Anti-obesity Effect (by Administration) of Wakame Seaweed (Undaria pinnatifida) Oil", MAIN POINTS OF LECTURES AT ACADEMIC MEETING OF THE JAPANESE SOCIETY OF FISHERIES SCIENCE, 2005, pages 130
ASAI, A ET AL.: "DRUG METABOLISM AND DISPOSITION", vol. 32, 2004, WILLIAMS AND WILKINS., article "Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxiciy of fucoxanthin metabolites", pages: 205 - 211
SUGAWARA T ET AL.: "JOURNAL OF NUTRITION", vol. 132, 2002, WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, article "Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice", pages: 946 - 951
MAEDA H. ET AL.: "Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 332, pages 392 - 397, XP027230012, DOI: doi:10.1016/j.bbrc.2005.05.002
See also references of EP 1884238A4
HOSOKAWA M. ET AL: "Kaiso Shishitsu no Shirarezaru Kenko Kino, Kasso Fucoxanthin ni Shibo Chikuseki Yokuse nado no Kino", KAGAKU TO SEIBUTSU, vol. 43, no. 3, March 2005 (2005-03-01), pages 150 - 152, XP003006019
KONISHI I. ET AL: "Gan Saibo ni Apoptosis o Yudo suru Ascidian Carotenoid no Tanri to Kino Kaiseki", NIPPON SUISAN GAKKAI KOEN YOSISHU, vol. 2005, April 2005 (2005-04-01), pages 128, XP003006020
MASASHI HOSOKAWA ET AL.: "Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPAR y ligand troglitazone, on colon cancer cells", BIOCHIMICA, ET BIOPHYSICAACTA, vol. 1675, 2004, pages 113 - 119, XP004630326, DOI: doi:10.1016/j.bbagen.2004.08.012
TAKAAKI KONNO ET AL.: "Anti-obesity Effect (by Administration) of Wakame Seaweed (Undaria pinnatifida) Oil", MAIN POINTS OF LECTURES AT ACADEMIC MEETING OF THE JAPANESE SOCIETY OF FISHERIES SCIENCE, 2005, pages 130
ASAI, A ET AL.: "DRUG METABOLISM AND DISPOSITION", vol. 32, 2004, WILLIAMS AND WILKINS., article "Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxiciy of fucoxanthin metabolites", pages: 205 - 211
SUGAWARA T ET AL.: "JOURNAL OF NUTRITION", vol. 132, 2002, WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, article "Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice", pages: 946 - 951
MAEDA H. ET AL.: "Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 332, pages 392 - 397, XP027230012, DOI: doi:10.1016/j.bbrc.2005.05.002
See also references of EP 1884238A4
Attorney, Agent or Firm:
Kaiguchi, Muneaki (Chandelle Bldg. 2-9-8, Shiba-Daimo, Minato-ku Tokyo 12, JP)
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