Title:
AGENT FOR INCREASING INTRACEREBRAL GABA
Document Type and Number:
WIPO Patent Application WO/2023/188173
Kind Code:
A1
Abstract:
Provided is a component capable of effectively increasing intracerebral GABA. An agent for increasing intracerebral γ-aminobutyric acid (GABA), the agent containing a compound represented by formula I. (In the formula, R is a side chain of an amino acid that is acceptable as a pharmaceutical or food product.)
Inventors:
SATO MIKAKO (JP)
SUGAWARA YUKIHIRO (JP)
YANAKA NORIYUKI (JP)
KUMRUNGSEE THANUTCHAPORN (JP)
SUGAWARA YUKIHIRO (JP)
YANAKA NORIYUKI (JP)
KUMRUNGSEE THANUTCHAPORN (JP)
Application Number:
PCT/JP2022/016205
Publication Date:
October 05, 2023
Filing Date:
March 30, 2022
Export Citation:
Assignee:
NH FOODS LTD (JP)
UNIV HIROSHIMA (JP)
UNIV HIROSHIMA (JP)
International Classes:
A61P9/12; A23L33/18; A61K31/195; A61K31/197; A61K31/4172; A61P25/20; A61P25/24; C07K5/06
Foreign References:
| JP2008088162A | 2008-04-17 | |||
| JP2015110564A | 2015-06-18 | |||
| US20060052428A1 | 2006-03-09 |
Other References:
MANYAM, BALA: "Influence of Precursors on Brain GABA Level", CLINICAL NEUROPHARMACOLOGY., RAVEN PRESS, NEW YORK, NY., US, vol. 10, no. 1, 1 February 1987 (1987-02-01), US , pages 38 - 46, XP009549223, ISSN: 0362-5664, DOI: 10.1097/00002826-198702000-00003
PETROFF O. A.C., HYDER, ROTHMAN, MATTSON: "Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures", NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS , PHILADELPHIA, US, vol. 56, no. 6, 27 March 2001 (2001-03-27), US , pages 709 - 715, XP009549225, ISSN: 0028-3878, DOI: 10.1212/wnl.56.6.709
OGNEN A. C. PETROFF; FAHMEED HYDER; THERESA COLLINS; RICHARD H. MATTSON; DOUGLAS L. ROTHMAN: "Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures", EPILEPSIA, RAVEN PRESS LTD, NEW YORK , US, vol. 40, no. 7, 4 October 2006 (2006-10-04), New York , US , pages 958 - 964, XP071205950, ISSN: 0013-9580, DOI: 10.1111/j.1528-1157.1999.tb00803.x
OGNEN A. C. PETROFF; FAHMEED HYDER; DOUGLAS L. ROTHMAN; RICHARD H. MATTSON: "Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients", EPILEPSIA, RAVEN PRESS LTD, NEW YORK , US, vol. 41, no. 6, 2 August 2005 (2005-08-02), New York , US , pages 675 - 680, XP071206369, ISSN: 0013-9580, DOI: 10.1111/j.1528-1157.2000.tb00227.x
PETROFF O. A.C., HYDER, ROTHMAN, MATTSON: "Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures", NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS , PHILADELPHIA, US, vol. 56, no. 6, 27 March 2001 (2001-03-27), US , pages 709 - 715, XP009549225, ISSN: 0028-3878, DOI: 10.1212/wnl.56.6.709
OGNEN A. C. PETROFF; FAHMEED HYDER; THERESA COLLINS; RICHARD H. MATTSON; DOUGLAS L. ROTHMAN: "Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures", EPILEPSIA, RAVEN PRESS LTD, NEW YORK , US, vol. 40, no. 7, 4 October 2006 (2006-10-04), New York , US , pages 958 - 964, XP071205950, ISSN: 0013-9580, DOI: 10.1111/j.1528-1157.1999.tb00803.x
OGNEN A. C. PETROFF; FAHMEED HYDER; DOUGLAS L. ROTHMAN; RICHARD H. MATTSON: "Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients", EPILEPSIA, RAVEN PRESS LTD, NEW YORK , US, vol. 41, no. 6, 2 August 2005 (2005-08-02), New York , US , pages 675 - 680, XP071206369, ISSN: 0013-9580, DOI: 10.1111/j.1528-1157.2000.tb00227.x
Attorney, Agent or Firm:
SIKS & CO. (JP)
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