Title:
AGENT AND METHOD FOR INDUCING DIFFERENTIATION FROM DENTAL PULP CELLS INTO ODONTOBLASTS
Document Type and Number:
WIPO Patent Application WO/2024/070172
Kind Code:
A1
Abstract:
Provided are an exceptional agent and method for inducing differentiation from dental pulp cells into odontoblasts. Also provided are an exceptional pharmaceutical composition and pulp capping agent for dentin regeneration. This agent for inducing differentiation from dental pulp cells into odontoblasts contains an ammonium salt and at least one selected from the group consisting of halous acids, halous acid ions, and halites. Furthermore, the pharmaceutical composition and/or pulp capping agent for dentin regeneration has the aforementioned differentiation-inducing agent as an active ingredient. More specifically, the differentiation-inducing agent induces differentiation from dental pulp cells into odontoblasts by causing desulfation of the sulfate groups of heparan sulfate proteoglycans on the dental pulp cell surface.
Inventors:
YAMASHIRO TAKASHI (JP)
INUBUSHI TOSHIHIRO (JP)
INUBUSHI TOSHIHIRO (JP)
Application Number:
PCT/JP2023/027169
Publication Date:
April 04, 2024
Filing Date:
July 25, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K6/54; A61K6/56; A61K31/14; A61K31/327; A61P43/00
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Download PDF:
Previous Patent: CABLE COVER AND CONSTANT-TEMPERATURE UNIT PROVIDED WITH SAME
Next Patent: CYLINDER DEVICE
Next Patent: CYLINDER DEVICE