Title:
PROPHYLACTIC/THERAPEUTIC AGENT FOR NON-ALCOHOLIC FATTY LIVER DISEASE/NON-ALCOHOLIC STEATOHEPATITIS AND LIVER CANCER
Document Type and Number:
WIPO Patent Application WO/2024/101406
Kind Code:
A1
Abstract:
The present invention provides a prophylactic and/or therapeutic agent for non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) or liver cancer, the agent containing a material for inhibiting the expression or function of WD repeat-containing protein 6 (WDR6) of non-alcoholic steatohepatitis.
Inventors:
CHIBA TAKUYA (JP)
KONDO YOSHITAKA (JP)
KONDO YOSHITAKA (JP)
Application Number:
PCT/JP2023/040311
Publication Date:
May 16, 2024
Filing Date:
November 08, 2023
Export Citation:
Assignee:
UNIV WASEDA (JP)
International Classes:
A61K45/00; A61K31/7088; A61K31/7105; A61K31/713; A61K39/395; A61K48/00; A61P1/16; A61P29/00; A61P35/00; A61P43/00; C07K16/18; C12N15/113; C12N15/12; G01N33/15; G01N33/50
Domestic Patent References:
| WO2008111520A1 | 2008-09-18 |
Other References:
BOREM LUCIANA M.; NETO JOãO F.; BRANDI IGOR V.; LELIS DEBORAH F; SANTOS SERGIO H.: "The role of the angiotensin II type I receptor blocker telmisartan in the treatment of non-alcoholic fatty liver disease: a brief review", HYPERTENSION RESEARCH. CLINICAL AND EXPERIMENTAL., OSAKA., JP, vol. 41, no. 6, 10 April 2018 (2018-04-10), JP , pages 394 - 405, XP036517881, ISSN: 0916-9636, DOI: 10.1038/s41440-018-0040-6
YAFUNE ATSUNORI; KAWAI MASAOMI; ITAHASHI MEGU; KIMURA MASAYUKI; NAKANE FUMIYUKI; MITSUMORI KUNITOSHI; SHIBUTANI MAKOTO: "Global DNA methylation screening of liver in piperonyl butoxide-treated mice in a two-stage hepatocarcinogenesis model", TOXICOLOGY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 222, no. 3, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 295 - 302, XP028726128, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2013.08.006
CHIBA, T. ; INOUE, D. ; MIZUNO, A. ; KOMATSU, T. ; FUJITA, S. ; KUBOTA, H. ; LUISA TAGLIARO, M. ; PARK, S. ; TRINDADE, L.S. ; HAYA: "Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: Implications for longevity", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 30, no. 3, 1 March 2009 (2009-03-01), US , pages 474 - 482, XP025897848, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2007.07.008
BAREFOOT MEGAN E.; CHEN YIFAN; VARGHESE RENCY S.; ZHOU YUAN; RESSOM HABTOM W.: "Integrative Analysis of DNA Methylation and Gene Expression Patterns in Tissues from Hepatocellular Carcinoma Patients", 2019 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM), IEEE, 18 November 2019 (2019-11-18), pages 267 - 274, XP033703902, DOI: 10.1109/BIBM47256.2019.8983070
YAFUNE ATSUNORI; KAWAI MASAOMI; ITAHASHI MEGU; KIMURA MASAYUKI; NAKANE FUMIYUKI; MITSUMORI KUNITOSHI; SHIBUTANI MAKOTO: "Global DNA methylation screening of liver in piperonyl butoxide-treated mice in a two-stage hepatocarcinogenesis model", TOXICOLOGY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 222, no. 3, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 295 - 302, XP028726128, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2013.08.006
CHIBA, T. ; INOUE, D. ; MIZUNO, A. ; KOMATSU, T. ; FUJITA, S. ; KUBOTA, H. ; LUISA TAGLIARO, M. ; PARK, S. ; TRINDADE, L.S. ; HAYA: "Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: Implications for longevity", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 30, no. 3, 1 March 2009 (2009-03-01), US , pages 474 - 482, XP025897848, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2007.07.008
BAREFOOT MEGAN E.; CHEN YIFAN; VARGHESE RENCY S.; ZHOU YUAN; RESSOM HABTOM W.: "Integrative Analysis of DNA Methylation and Gene Expression Patterns in Tissues from Hepatocellular Carcinoma Patients", 2019 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM), IEEE, 18 November 2019 (2019-11-18), pages 267 - 274, XP033703902, DOI: 10.1109/BIBM47256.2019.8983070
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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