Title:
AGENT FOR PREVENTING OR AMELIORATING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/078005
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an agent for preventing or ameliorating Alzheimer's disease, said agent being able to effectively suppress the accumulation of amyloid β proteins using a safe material, which has been used in foods for many years, and improve spontaneous alternation behavior change ratio. Ceramides (in particular, a glucosylceramide originating in Amorphophallus konjac) can effectively suppress the accumulation of amyloid β proteins and thus enables the prevention or amelioration of Alzheimer's disease.
Inventors:
TAKAHASHI KAORI (JP)
MUKAI KATSUYUKI (JP)
IGARASHI YASUYUKI (JP)
YUYAMA KOHEI (JP)
MUKAI KATSUYUKI (JP)
IGARASHI YASUYUKI (JP)
YUYAMA KOHEI (JP)
Application Number:
PCT/JP2018/037018
Publication Date:
April 25, 2019
Filing Date:
October 03, 2018
Export Citation:
Assignee:
DAICEL CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A23L33/135; A61K31/164; A61K31/7028; A61K36/888; A61P25/28
Domestic Patent References:
| WO2018212250A1 | 2018-11-22 | |||
| WO2008087704A1 | 2008-07-24 |
Foreign References:
| KR20180091223A | 2018-08-16 | |||
| JPH08113535A | 1996-05-07 | |||
| JP2016145175A | 2016-08-12 | |||
| JP2014224132A | 2014-12-04 |
Other References:
TAKAHASHI, KAORI ET AL.: "3B03p03 Preventive effects of dietary konjac ceramide on the Alzheimer's brain", ANNUAL MEETING OF THE JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2018 (JSBBA 2018), vol. 2018, March 2018 (2018-03-01), pages 1810, XP055612902
YUYAMA, K. ET AL.: "Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia", J. BIOL. CHEM., vol. 287, no. 14, 2012, pages 10977 - 10989, XP055200773, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.324616
GOODMAN, Y. ET AL.: "Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity", J. NEUROCHEM., vol. 66, no. 2, February 1996 (1996-02-01), pages 869 - 872, XP055597993, ISSN: 0022-3042
MUKAI, KATSUYUKI: "Function of an edible ceramide extracted from the tuber of konjac", BIO INDUSTRY = BAIOINDASUTORI, vol. 19, no. 8, 2002, pages 16 - 26, XP009520259, ISSN: 0910-6545
IGARASHI, YASUYUKI: "Creation of functional material containing agriculture and forestry product-derived ceramide", JOURNAL OF AGRICULTURAL AND FOOD TECHNOLOGY, vol. 12, no. 1, 2016, pages 21 - 24, XP009520297, ISSN: 1880-2346
See also references of EP 3698649A4
YUYAMA, K. ET AL.: "Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia", J. BIOL. CHEM., vol. 287, no. 14, 2012, pages 10977 - 10989, XP055200773, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.324616
GOODMAN, Y. ET AL.: "Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity", J. NEUROCHEM., vol. 66, no. 2, February 1996 (1996-02-01), pages 869 - 872, XP055597993, ISSN: 0022-3042
MUKAI, KATSUYUKI: "Function of an edible ceramide extracted from the tuber of konjac", BIO INDUSTRY = BAIOINDASUTORI, vol. 19, no. 8, 2002, pages 16 - 26, XP009520259, ISSN: 0910-6545
IGARASHI, YASUYUKI: "Creation of functional material containing agriculture and forestry product-derived ceramide", JOURNAL OF AGRICULTURAL AND FOOD TECHNOLOGY, vol. 12, no. 1, 2016, pages 21 - 24, XP009520297, ISSN: 1880-2346
See also references of EP 3698649A4
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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