Title:
AGENT FOR PREVENTING MYOPIA, TREATING MYOPIA, AND/OR PREVENTING MYOPIA PROGRESSION COMPRISING TIOTROPIUM AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/174149
Kind Code:
A1
Abstract:
The present invention relates to an agent for preventing myopia, treating myopia, and/or preventing myopia progression, comprising tiotropium as an active ingredient.
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Inventors:
TAN DONALD (SG)
BEUERMAN ROGER (SG)
SAW SEANG-MEI (SG)
UPADHYAY ARADHANA (SG)
KATO MASATOMO (JP)
INABA TAKAAKI (JP)
BEUERMAN ROGER (SG)
SAW SEANG-MEI (SG)
UPADHYAY ARADHANA (SG)
KATO MASATOMO (JP)
INABA TAKAAKI (JP)
Application Number:
PCT/JP2018/011361
Publication Date:
September 27, 2018
Filing Date:
March 22, 2018
Export Citation:
Assignee:
SINGAPORE HEALTH SERV PTE LTD (SG)
SANTEN PHARMACEUTICAL CO LTD (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/439; A61P27/10
Domestic Patent References:
| WO2009045172A1 | 2009-04-09 | |||
| WO1996013262A1 | 1996-05-09 |
Other References:
BARNES, PETER J ET AL.: "TIOTROPIUM BROMIDE (Ba679 BR ) ,A NOVEL LONG-ACTING MUSCARINIC ANTAGONIST FOR THE TREATMENT OF OBSTRUCTIVE AIRWAYS DISEASE", LIFE SCIENCES, vol. 56, no. 11 / 12, 1995, pages 853 - 859, XP055558668
LUFT,W. ALANA ET AL.: "Variable Effects of Previously Untested Muscarinic Receptor Antagonists on Experimental Myopia", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 44, no. 3, March 2003 (2003-03-01), pages 1330 - 1338, XP002315956
BARATHI, VELUCHAMY A. ET AL.: "Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice", DISEASE MODELS & MECHANISMS, vol. 6, 2013, pages 1146 - 1158, XP055545977
MITCHELSON, FREDERICK ET AL.: "Muscarinic Receptor Agonists and Antagonists :Effects on Ocular Function", HANDBOOK OF EXPERIMENTAL PHARMACOLOGY 208 MUSCARINIC RECEPTORS, 2012, pages 263 - 298, XP009193308, ISSN: 0171-2004
See also references of EP 3600306A4
LUFT,W. ALANA ET AL.: "Variable Effects of Previously Untested Muscarinic Receptor Antagonists on Experimental Myopia", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 44, no. 3, March 2003 (2003-03-01), pages 1330 - 1338, XP002315956
BARATHI, VELUCHAMY A. ET AL.: "Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice", DISEASE MODELS & MECHANISMS, vol. 6, 2013, pages 1146 - 1158, XP055545977
MITCHELSON, FREDERICK ET AL.: "Muscarinic Receptor Agonists and Antagonists :Effects on Ocular Function", HANDBOOK OF EXPERIMENTAL PHARMACOLOGY 208 MUSCARINIC RECEPTORS, 2012, pages 263 - 298, XP009193308, ISSN: 0171-2004
See also references of EP 3600306A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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