Title:
AGENT FOR PROMOTING DECREASE IN 8-OHDG CONCENTRATION, AGENT FOR PROMOTING DECREASE IN MALONDIALDEHYDE (MDA) CONCENTRATION, AGENT FOR PROMOTING INCREASE IN ZIP4 CONCENTRATION, OR AGENT FOR PROMOTING INCREASE IN SERUM ZINC CONCENTRATION IN JEJUNUM
Document Type and Number:
WIPO Patent Application WO/2023/233820
Kind Code:
A1
Abstract:
[Problem] The purpose of the present invention is to provide an agent for promoting a decrease in MDA concentration, an agent for promoting a decrease in 8-OHdG concentration, an agent for promoting an increase in ZIP4 concentration, or an agent for promoting an increase in serum zinc concentration in the jejunum with which it is possible to promote a decrease in MDA concentration, promote a decrease in 8-OHdG concentration, promote an increase in ZIP4 concentration, and promote an increase in serum zinc concentration in the jejunum to improve a state of oxidative stress. [Solution] The present invention is characterized by having 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient and having an 8-OHdG concentration lowering promoting action to lower the 8-OHdG concentration in the jejunum.
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Inventors:
WATANABE MITSUGU (JP)
WATANABE HIDEAKI (JP)
WATANABE HIDEAKI (JP)
Application Number:
PCT/JP2023/014234
Publication Date:
December 07, 2023
Filing Date:
April 06, 2023
Export Citation:
Assignee:
WATANABE OYSTER LABORATORY CO LTD (JP)
International Classes:
A61K31/085; A23L33/10; A61K35/618; A61P1/00; A61P39/02; A61P39/06; A61P43/00
Foreign References:
| JP2019043881A | 2019-03-22 | |||
| JP2015100344A | 2015-06-04 | |||
| JP2010057455A | 2010-03-18 | |||
| JP2023060981A | 2023-05-01 |
Other References:
WATANABE, MITSUGU: "B2-5: Effect of Japanese Oyster Molluscous Part-Derived Extraction Fractions and Antioxidant DHMBA on Rat Intestine Oxidative Stress and Zinc Transporter ZIP4 Amount", ABSTRACTS OF THE 28TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR DISEASE CONTROL AND PREVENTION; NOVEMBER 20-21, 2021, 1 January 2021 (2021-01-01), pages 108, XP009551345
YUSHIKAZU MATSUDA; SHOKO KITANI; SACHIKO KITANI; KENJI FUKUNAGA; MUNEHIRO YOSHIDA: "Preparation of Zinc-Rich Powder from Oysters and Evaluation of Its Bioavailability", BIOMEDICAL RESEARCH ON TRACE ELEMENTS, NIHON BIRYO GENSO GAKKAI, TOKYO, JP, vol. 14, no. 4, 1 January 2003 (2003-01-01), JP , pages 302 - 306, XP009551343, ISSN: 0916-717X
CHEN HUI, ZHENG HUIZHEN, LI TIEJUN, JIANG QIHONG, LIU SHULAI, ZHOU XUXIA, DING YUTING, XIANG XINGWEI: "Protective Effect of Oyster Peptides Derived From Crassostrea gigas on Intestinal Oxidative Damage Induced by Cyclophosphamide in Mice Mediated Through Nrf2-Keap1 Signaling Pathway", FRONTIERS IN NUTRITION, FRONTIERS MEDIA, LAUSANNE, vol. 9, Lausanne , XP093115427, ISSN: 2296-861X, DOI: 10.3389/fnut.2022.888960
YUSHIKAZU MATSUDA; SHOKO KITANI; SACHIKO KITANI; KENJI FUKUNAGA; MUNEHIRO YOSHIDA: "Preparation of Zinc-Rich Powder from Oysters and Evaluation of Its Bioavailability", BIOMEDICAL RESEARCH ON TRACE ELEMENTS, NIHON BIRYO GENSO GAKKAI, TOKYO, JP, vol. 14, no. 4, 1 January 2003 (2003-01-01), JP , pages 302 - 306, XP009551343, ISSN: 0916-717X
CHEN HUI, ZHENG HUIZHEN, LI TIEJUN, JIANG QIHONG, LIU SHULAI, ZHOU XUXIA, DING YUTING, XIANG XINGWEI: "Protective Effect of Oyster Peptides Derived From Crassostrea gigas on Intestinal Oxidative Damage Induced by Cyclophosphamide in Mice Mediated Through Nrf2-Keap1 Signaling Pathway", FRONTIERS IN NUTRITION, FRONTIERS MEDIA, LAUSANNE, vol. 9, Lausanne , XP093115427, ISSN: 2296-861X, DOI: 10.3389/fnut.2022.888960
Attorney, Agent or Firm:
ITO Giichiro (JP)
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