Title:
AGENT FOR TARGETING DRUG TO CEREBRAL NEURON
Document Type and Number:
WIPO Patent Application WO/2007/086587
Kind Code:
A1
Abstract:
Disclosed are: a drug-targeting agent, specifically a targeting agent for introducing a drug into a cerebral neuron; a pharmaceutical comprising the targeting agent and a drug; and a method for targeting a drug to a cerebral neuron.
Inventors:
KUCHIIWA SATOSHI (JP)
KUCHIIWA TOSHIKO (JP)
KUCHIIWA TOSHIKO (JP)
Application Number:
PCT/JP2007/051528
Publication Date:
August 02, 2007
Filing Date:
January 24, 2007
Export Citation:
Assignee:
UNIV KAGOSHIMA (JP)
KUCHIIWA SATOSHI (JP)
KUCHIIWA TOSHIKO (JP)
KUCHIIWA SATOSHI (JP)
KUCHIIWA TOSHIKO (JP)
International Classes:
A61K47/48; A61K47/42; A61P25/16; A61P25/24; A61P25/28; A61P43/00
Domestic Patent References:
| WO2004060403A2 | 2004-07-22 |
Other References:
ALISKY J.M. ET AL.: "Widespread dispersal of cholera toxin subunit b to brain and spinal cord neurons following systemic delivery", EXP. NEUROL., vol. 178, no. 1, 2002, pages 139 - 146, XP003024516
SCHWAB M.E. AND THOENEN H.: "Selective binding, uptake, and retrograde transport of tetanus toxin by nerve terminals in the rat iris An electron microscope study using colloidal gold as a tracer", J. CELL BIOL., vol. 77, no. 1, 1978, pages 1 - 13, XP003016616
ZHANG ET AL: "The distributions and signalling directions of the cerebrospinal fluid contacting neurons in the parenchyma of a rat brain", BRAIN RESEARCH, vol. 989, 2003, pages 1 - 8, XP003016617
See also references of EP 1985311A4
SCHWAB M.E. AND THOENEN H.: "Selective binding, uptake, and retrograde transport of tetanus toxin by nerve terminals in the rat iris An electron microscope study using colloidal gold as a tracer", J. CELL BIOL., vol. 77, no. 1, 1978, pages 1 - 13, XP003016616
ZHANG ET AL: "The distributions and signalling directions of the cerebrospinal fluid contacting neurons in the parenchyma of a rat brain", BRAIN RESEARCH, vol. 989, 2003, pages 1 - 8, XP003016617
See also references of EP 1985311A4
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
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