Title:
AGENT FOR TREATING OR PREVENTING KIDNEY STONES
Document Type and Number:
WIPO Patent Application WO/2024/014463
Kind Code:
A1
Abstract:
The present invention provides a drug for suppressing the growth of kidney stones, the drug containing a peptide that includes an amino acid sequence satisfying the following conditions or a nucleic acid that encodes said peptide: (1) Amino acid sequence of 20 or more contiguous amino acids in a region composed of an apoptosis inhibitor of macrophage (AIM) SRCR1 domain and a hinge region; and (2) (number of aspartic acids and glutamic acids in said amino acid sequence)−(number of arginines and lysines in said amino acid sequence)≥5.
Inventors:
MIYAZAKI TORU (JP)
ARAI SATOKO (JP)
MATSUURA KYOHEI (JP)
ARAI SATOKO (JP)
MATSUURA KYOHEI (JP)
Application Number:
PCT/JP2023/025598
Publication Date:
January 18, 2024
Filing Date:
July 11, 2023
Export Citation:
Assignee:
MIYAZAKI TORU (JP)
International Classes:
A61K38/02; A61K31/711; A61K38/16; A61P13/12; C07K7/08; C07K14/00; C12N15/12
Domestic Patent References:
| WO2020071318A1 | 2020-04-09 | |||
| WO2016190387A1 | 2016-12-01 | |||
| WO2015119253A1 | 2015-08-13 |
Other References:
SUGISAWA RYOICHI, KOMATSU GINGA, HIRAMOTO EMIRI, TAKEDA NAOKI, YAMAMURA KEN-ICHI, ARAI SATOKO, MIYAZAKI TORU: "Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 8, no. 1, US , XP093127449, ISSN: 2045-2322, DOI: 10.1038/s41598-018-31580-6
MATSUURA KYOHEI, MAEHARA NATSUMI, HIROTA AIKA, EGUCHI AYAKA, YASUDA KEISUKE, TANIGUCHI KAORI, NISHIJIMA AKEMI, MATSUHASHI NOBUYUKI: "Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1", COMMUNICATIONS BIOLOGY, vol. 5, no. 1, XP093127451, ISSN: 2399-3642, DOI: 10.1038/s42003-022-03750-w
MATSUURA KYOHEI, MAEHARA NATSUMI, HIROTA AIKA, EGUCHI AYAKA, YASUDA KEISUKE, TANIGUCHI KAORI, NISHIJIMA AKEMI, MATSUHASHI NOBUYUKI: "Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1", COMMUNICATIONS BIOLOGY, vol. 5, no. 1, XP093127451, ISSN: 2399-3642, DOI: 10.1038/s42003-022-03750-w
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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