Title:
AGENT FOR TREATING OR PREVENTING SYSTEMIC INFLAMMATORY RESPONSE SYNDROME
Document Type and Number:
WIPO Patent Application WO/2013/191280
Kind Code:
A1
Abstract:
The present invention provides an agent for treating or preventing systemic inflammatory response syndrome (SIRS) containing: a polypeptide comprising the same or substantially the same amino acid sequence as the N-terminus domain of pentraxin 3, able to bind to histones to form a polypeptide aggregate; or a pharmacologically acceptable salt thereof. The present invention also provides a quantifying method and reagent for quantifying histones using said polypeptide or pharmacologically acceptable salt thereof. The present invention furthermore provides a polypeptide aggregate comprising said polypeptide or pharmacologically acceptable salt thereof and histones, and a method for producing the same.
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Inventors:
HAMAKUBO TAKAO (JP)
TSUMOTO KOUHEI (JP)
DAIGO KENJI (JP)
INOUE KENJI (JP)
YAMAGUCHI NAOTAKA (JP)
MIZUUCHI MOTOAKI (JP)
FUJII HIROYA (JP)
TSUMOTO KOUHEI (JP)
DAIGO KENJI (JP)
INOUE KENJI (JP)
YAMAGUCHI NAOTAKA (JP)
MIZUUCHI MOTOAKI (JP)
FUJII HIROYA (JP)
Application Number:
PCT/JP2013/067122
Publication Date:
December 27, 2013
Filing Date:
June 21, 2013
Export Citation:
Assignee:
UNIV TOKYO (JP)
JUNTENDO EDUCATIONAL FOUNDATION (JP)
PERSEUS PROTEOMICS INC (JP)
JSR CORP (JP)
JUNTENDO EDUCATIONAL FOUNDATION (JP)
PERSEUS PROTEOMICS INC (JP)
JSR CORP (JP)
International Classes:
A61K38/00; A61P29/00; C07K14/435; C12P21/02; C12N15/09
Foreign References:
| JP2004513151A | 2004-04-30 | |||
| JP2004512372A | 2004-04-22 | |||
| JP2002503642A | 2002-02-05 |
Other References:
DIAS,A.A. ET AL.: "TSG-14 transgenic mice have improved survival to endotoxemia and to CLP- induced sepsis", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 69, no. 6, 2001, pages 928 - 36, XP055182480
DAIGO,K. ET AL.: "The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps", MOLECULAR AND CELLULAR PROTEOMICS, vol. 11, no. 6, January 2012 (2012-01-01), pages M111. 015073, P.1 - 12, XP055182528
SAUNERO-NAVA,L. ET AL.: "Hamster female protein binding to chromatin, histones and DNA", MOLECULAR IMMUNOLOGY, vol. 29, no. 7-8, 1992, pages 837 - 45, XP023682633
DAIGO,K. ET AL.: "Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps", FRONTIERS IN IMMUNOLOGY, vol. 3, December 2012 (2012-12-01), pages 378, XP055182532
BOTTAZZI, B. ET AL., ANNUAL REVIEW OF IMMUNOLOGY, vol. 28, 2010, pages 157 - 183
INFORZATO, A. ET AL., J BIOL CHEM, vol. 283, 2008, pages 10147 - 10161
JAILLON, S. ET AL., J EXP MED, vol. 204, 2007, pages 793 - 804
MANTOVANI, A. ET AL., J CLIN IMMUNOL, vol. 28, 2008, pages 1 - 13
MAURI, T. ET AL., INTENSIVE CARE MED, vol. 36, 2010, pages 621 - 629
DIAS, A. A. ET AL., J LEUKOC BIOL, vol. 69, 2001, pages 928 - 936
SAVCHENKO, A. ET AL., THE JOURNAL OF PATHOLOGY, vol. 215, 2008, pages 48 - 55
DAIGO,K. ET AL.: "The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps", MOLECULAR AND CELLULAR PROTEOMICS, vol. 11, no. 6, January 2012 (2012-01-01), pages M111. 015073, P.1 - 12, XP055182528
SAUNERO-NAVA,L. ET AL.: "Hamster female protein binding to chromatin, histones and DNA", MOLECULAR IMMUNOLOGY, vol. 29, no. 7-8, 1992, pages 837 - 45, XP023682633
DAIGO,K. ET AL.: "Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps", FRONTIERS IN IMMUNOLOGY, vol. 3, December 2012 (2012-12-01), pages 378, XP055182532
BOTTAZZI, B. ET AL., ANNUAL REVIEW OF IMMUNOLOGY, vol. 28, 2010, pages 157 - 183
INFORZATO, A. ET AL., J BIOL CHEM, vol. 283, 2008, pages 10147 - 10161
JAILLON, S. ET AL., J EXP MED, vol. 204, 2007, pages 793 - 804
MANTOVANI, A. ET AL., J CLIN IMMUNOL, vol. 28, 2008, pages 1 - 13
MAURI, T. ET AL., INTENSIVE CARE MED, vol. 36, 2010, pages 621 - 629
DIAS, A. A. ET AL., J LEUKOC BIOL, vol. 69, 2001, pages 928 - 936
SAVCHENKO, A. ET AL., THE JOURNAL OF PATHOLOGY, vol. 215, 2008, pages 48 - 55
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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