AGGLOMERATED PARTICLES FOR AEROSOL DRUG DELIVERY

Title:

AGGLOMERATED PARTICLES FOR AEROSOL DRUG DELIVERY

Document Type and Number:

WIPO Patent Application WO2003075977

Kind Code:

A3

Abstract:

The invention provides a drug delivery vehicle for inhalation by a patient. The drug delivery vehicle comprises biocompatible particles between 0.1 and 1.0 microns in diameter, that are loaded with one or more drugs and which are crosslinked together to form agglomerates. The agglomerates can also provide for delivery of contrast-enhancing agents for clinical imaging. The invention also provides methods of making the inventive agglomerates, pharmaceutical compositions comprising the agglomerates, and methods for delivering drugs or contrast-enhancing agents to a patient by inhalation of pharmaceutical compositions containing the agglomerates.

Inventors:

ANNAPRAGADA ANNANTH (US)
BHAVANE ROHAN (US)

Application Number:

PCT/US2003/006797

Publication Date:

December 04, 2003

Filing Date:

March 05, 2003

Export Citation:

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Assignee:

UNIV STATE CLEVELAND (US)
ANNAPRAGADA ANNANTH (US)
BHAVANE ROHAN (US)

International Classes:

A61K9/72; A61K9/00; A61K9/12; A61K9/127; A61K9/16; A61K9/26; A61K38/28; A61K47/44; A61K47/48; A61K49/00; A61P3/10; (IPC1-7): A61K9/127; A61B5/055; A61K49/00

Foreign References:

US5059421A	1991-10-22
US5654007A	1997-08-05
US6120751A	2000-09-19

Other References: