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Title:
AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF OPIOID INDUCED DYSFUNCTIONS
Document Type and Number:
WIPO Patent Application WO/2015/054649
Kind Code:
A3
Abstract:
The disclosure provides a method to prevent, control, and/or treat opioid induced dysfunctions comprising administering to a patient in need a guanylate cyclase receptor agonist (GCRA) peptide. Compositions comprising guanylate cyclase receptor agonist (GCRA) peptides, methods of making, and methods of treatment are also disclosed. Further disclosed are the guanylate cyclase receptor agonist (GCRA) peptide and opioid formulated in the same composition.

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Inventors:
SHAILUBHAI KUNWAR (US)
PALEJWALA VASEEM (US)
Application Number:
PCT/US2014/060157
Publication Date:
August 06, 2015
Filing Date:
October 10, 2014
Export Citation:
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Assignee:
SYNERGY PHARMACEUTICALS INC (US)
International Classes:
A61K38/00; A61K38/10; A61K38/12
Foreign References:
US20120237593A12012-09-20
US20120220526A12012-08-30
Other References:
ARSHAD ET AL.: "The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis.", FEBS LETT., vol. 586, no. 18, August 2012 (2012-08-01), pages 2835 - 40, XP055216235
Attorney, Agent or Firm:
ELRIFI, Ivor et al. (1299 Pennsylvania Avenue N.W.,Suite 70, Washington District of Columbia, US)
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