Title:
AGONISTS OF NR2F6 FOR IMMUNOSUPPRESSION
Document Type and Number:
WIPO Patent Application WO/2010/004052
Kind Code:
A3
Abstract:
The present invention relates to agonists/activators of NR2F6 (nuclear orphan receptor receptor Ear2) for the treatment of a disease related to an augmented immune response. Furthermore, pharmaceutical compositions comprising said agonists/activators of NR2F6 and a pharmaceutical carrier are comprised. In a further aspect, the present invention provides for a method for identifying immunosuppressants comprising contacting a cell, tissue or a non-human animal comprising a reporter construct for NR2F6-activation with a candidate molecule, measuring the reporter signal and selecting a candidate molecule which alters the reporter signal. Furthermore, the present invention relates to non-human transgenic animals or cells or tissue derived therefrom useful in the provided methods for identifying immunosuppressants. In yet another aspect, the present invention relates to ligand-mediated reporter gene expression constructs, ligand displacement constructs, fluorescent cellular sensor fusion mutant constructs, and ligand-induced homo- and/or heterodimer constructs useful in the provided methods for identifying immunosuppressants.
Inventors:
BAIER GOTTFRIED (AT)
HERMANN-KLEITER NATASCHA (AT)
HERMANN-KLEITER NATASCHA (AT)
Application Number:
PCT/EP2009/058882
Publication Date:
April 15, 2010
Filing Date:
July 10, 2009
Export Citation:
Assignee:
UNIV INNSBRUCK (AT)
BAIER GOTTFRIED (AT)
HERMANN-KLEITER NATASCHA (AT)
BAIER GOTTFRIED (AT)
HERMANN-KLEITER NATASCHA (AT)
International Classes:
A01K67/00; A61K38/17; A61P37/06; C07K14/00; C12N15/00; C12Q1/00
Domestic Patent References:
| WO2005017112A2 | 2005-02-24 | |||
| WO2000025134A1 | 2000-05-04 | |||
| WO2001055349A1 | 2001-08-02 |
Other References:
WARNECKE MAREI ET AL: "Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 19, no. 5, 1 March 2005 (2005-03-01), pages 614 - 625, XP002556539, ISSN: 0890-9369
Attorney, Agent or Firm:
VOSSIUS & PARTNER (München, DE)
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