Title:
AKKERMANSIA MUCINIPHILA AND USE THEREOF IN PREPARING ANTI-TUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2023/184631
Kind Code:
A1
Abstract:
An Akkermansia muciniphila, with an accession number of CGMCC No. 23185. Use of the Akkermansia muciniphila in preparing a drug for preventing and/or treating a pancreatic tumor. A composition, comprising the Akkermansia muciniphila as an active ingredient. Use of the Akkermansia muciniphila in preparing a pharmaceutical composition for enhancing the efficacy of an anti-tumor drug. A culture or a processing product thereof comprising the Akkermansia muciniphila. The Akkermansia muciniphila has better growth and proliferation ability, can secrete more key immunoregulatory substances such as palmitoleic acid and the like, more effectively inhibit the number of CD8+ T cells to further inhibit the growth of pancreatic tumor cells, and also significantly increase the concentration of a chemotherapeutic drug in a pancreatic tumor microenvironment, so that the efficacy of the anti-tumor drug is enhanced.
Inventors:
XU ZHAOYING (CN)
AN QIULIN (CN)
MIN XIANGBIN (CN)
AN QIULIN (CN)
MIN XIANGBIN (CN)
Application Number:
PCT/CN2022/089199
Publication Date:
October 05, 2023
Filing Date:
April 26, 2022
Export Citation:
Assignee:
REVAISSANT SHENZHEN BIOSCIENCES CO LTD (CN)
International Classes:
A61P1/00; C12N1/20; A61P1/18; A61P35/00; C07K14/195; C12R1/01
Domestic Patent References:
| WO2021060945A1 | 2021-04-01 |
Foreign References:
| CN113862193A | 2021-12-31 | |||
| CN110496140A | 2019-11-26 | |||
| CN112933115A | 2021-06-11 |
Other References:
WANG LIJUAN, TANG LEI, FENG YIMING, ZHAO SUYING, HAN MEI, ZHANG CHUAN, YUAN GEHUI, ZHU JUN, CAO SHUYUAN, WU QIAN, LI LEI, ZHANG ZH: "A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 + T cells in mice", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 69, no. 11, 1 November 2020 (2020-11-01), UK , pages 1988 - 1997, XP093059536, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2019-320105
JEONG JIN-YONG, KIM TAE-BUM, KIM JINJU, CHOI HWI WAN, KIM EO JIN, YOO HYUN JU, LEE SONG, JUN HYE RYEONG, YOO WONBEAK, KIM SEOKHO, : "Diversity in the Extracellular Vesicle-Derived Microbiome of Tissues According to Tumor Progression in Pancreatic Cancer", CANCERS, vol. 12, no. 9, pages 2346, XP093095409, DOI: 10.3390/cancers12092346
BERTRAND ROUTY; EMMANUELLE LE CHATELIER; LISA DEROSA; CONNIE P M DUONG; MARYAM TIDJANI ALOU; ROMAIN DAILLÈRE; AURÉLIE FLUCKIGER; M: "Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 359, no. 6371, 5 January 2018 (2018-01-05), US , pages 91 - 97, XP055554928, ISSN: 0036-8075, DOI: 10.1126/science.aan3706
HOU XIAOYING, ZHANG PEI, DU HONGZHI, CHU WEIHUA, SUN RUIQI, QIN SIYUAN, TIAN YUAN, ZHANG ZUNJIAN, XU FENGGUO: "Akkermansia Muciniphila Potentiates the Antitumor Efficacy of FOLFOX in Colon Cancer", FRONTIERS IN PHARMACOLOGY, vol. 12, XP093095417, DOI: 10.3389/fphar.2021.725583
JEONG JIN-YONG, KIM TAE-BUM, KIM JINJU, CHOI HWI WAN, KIM EO JIN, YOO HYUN JU, LEE SONG, JUN HYE RYEONG, YOO WONBEAK, KIM SEOKHO, : "Diversity in the Extracellular Vesicle-Derived Microbiome of Tissues According to Tumor Progression in Pancreatic Cancer", CANCERS, vol. 12, no. 9, pages 2346, XP093095409, DOI: 10.3390/cancers12092346
BERTRAND ROUTY; EMMANUELLE LE CHATELIER; LISA DEROSA; CONNIE P M DUONG; MARYAM TIDJANI ALOU; ROMAIN DAILLÈRE; AURÉLIE FLUCKIGER; M: "Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 359, no. 6371, 5 January 2018 (2018-01-05), US , pages 91 - 97, XP055554928, ISSN: 0036-8075, DOI: 10.1126/science.aan3706
HOU XIAOYING, ZHANG PEI, DU HONGZHI, CHU WEIHUA, SUN RUIQI, QIN SIYUAN, TIAN YUAN, ZHANG ZUNJIAN, XU FENGGUO: "Akkermansia Muciniphila Potentiates the Antitumor Efficacy of FOLFOX in Colon Cancer", FRONTIERS IN PHARMACOLOGY, vol. 12, XP093095417, DOI: 10.3389/fphar.2021.725583
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
Download PDF: