Title:
AKT INHIBITOR IN COMBINATION WITH PIM KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/202563
Kind Code:
A1
Abstract:
Provided herein is a combination of an AKT inhibitor and a PIM kinase inhibitor for use in treating cancer, such as AKT inhibitor resistant cancer, in a subject in need thereof. Also provided is a composition comprising the same.
Inventors:
SHEN ZHENHAI (CN)
LIN KUI (US)
LIN KUI (US)
Application Number:
PCT/CN2023/088917
Publication Date:
October 26, 2023
Filing Date:
April 18, 2023
Export Citation:
Assignee:
NEWBAY TECH DEVELOPMENT CO LTD (CN)
GENENTECH INC (US)
GENENTECH INC (US)
International Classes:
A61K45/06; A61K31/427; A61K31/517; A61P35/00
Domestic Patent References:
| WO2014048939A1 | 2014-04-03 |
Foreign References:
| US20110059961A1 | 2011-03-10 | |||
| US20130079321A1 | 2013-03-28 |
Other References:
CEN BO, MAHAJAN SANDEEP, WANG WENXUE, KRAFT ANDREW S.: "Elevation of Receptor Tyrosine Kinases by Small Molecule AKT Inhibitors in Prostate Cancer Is Mediated by Pim-1", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 73, no. 11, 1 June 2013 (2013-06-01), US, pages 3402 - 3411, XP093100630, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-4619
OKADA KEIGO, NOGAMI AYAKO, ISHIDA SHINYA, AKIYAMA HIROKI, CHEN CHENG, UMEZAWA YOSHIHIRO, MIURA OSAMU: "FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway", ONCOTARGET, vol. 9, no. 10, 6 February 2018 (2018-02-06), pages 8870 - 8886, XP093100633, DOI: 10.18632/oncotarget.22926
MEJA K. ET AL.: "PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways", BRITISH JOURNAL OF HAEMATOLOGY, vol. 167, 30 June 2014 (2014-06-30), pages 69 - 79, XP071135530, DOI: 10.1111/bjh.13013
LEE MISO, LEE KYUNG-HUN, MIN AHRUM, KIM JEONGEUN, KIM SEONGYEONG, JANG HYEMIN, LIM JEE MIN, KIM SO HYEON, HA DONG-HYEON, JEONG WON: "Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells", CANCER RESEARCH AND TREATMENT, KOREAN CANCER ASSOCIATION, KR, vol. 51, no. 2, 15 April 2019 (2019-04-15), KR , pages 451 - 463, XP093100636, ISSN: 1598-2998, DOI: 10.4143/crt.2017.341
WARFEL N. A. ET AL.: "PIM kinase (and Akt) biology and signaling in tumors", PHARMACOLOGY & THERAPEUTICS, vol. 151, 5 March 2015 (2015-03-05), pages 41 - 49, XP029182820, DOI: 10.1016/j.pharmthera.2015.03.001
SAVILL KRISTIN M. ZIMMERMAN, LEE BRIAN B., OEH JASON, LIN JIE, LIN EVA, CHUNG WEI-JEN, YOUNG AMY, CHEN WENNIE, MIŚ MONIKA, MESH KA: "Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors", NATURE COMMUNICATIONS, vol. 13, no. 1, XP093100641, DOI: 10.1038/s41467-022-29655-0
OKADA KEIGO, NOGAMI AYAKO, ISHIDA SHINYA, AKIYAMA HIROKI, CHEN CHENG, UMEZAWA YOSHIHIRO, MIURA OSAMU: "FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway", ONCOTARGET, vol. 9, no. 10, 6 February 2018 (2018-02-06), pages 8870 - 8886, XP093100633, DOI: 10.18632/oncotarget.22926
MEJA K. ET AL.: "PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways", BRITISH JOURNAL OF HAEMATOLOGY, vol. 167, 30 June 2014 (2014-06-30), pages 69 - 79, XP071135530, DOI: 10.1111/bjh.13013
LEE MISO, LEE KYUNG-HUN, MIN AHRUM, KIM JEONGEUN, KIM SEONGYEONG, JANG HYEMIN, LIM JEE MIN, KIM SO HYEON, HA DONG-HYEON, JEONG WON: "Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells", CANCER RESEARCH AND TREATMENT, KOREAN CANCER ASSOCIATION, KR, vol. 51, no. 2, 15 April 2019 (2019-04-15), KR , pages 451 - 463, XP093100636, ISSN: 1598-2998, DOI: 10.4143/crt.2017.341
WARFEL N. A. ET AL.: "PIM kinase (and Akt) biology and signaling in tumors", PHARMACOLOGY & THERAPEUTICS, vol. 151, 5 March 2015 (2015-03-05), pages 41 - 49, XP029182820, DOI: 10.1016/j.pharmthera.2015.03.001
SAVILL KRISTIN M. ZIMMERMAN, LEE BRIAN B., OEH JASON, LIN JIE, LIN EVA, CHUNG WEI-JEN, YOUNG AMY, CHEN WENNIE, MIŚ MONIKA, MESH KA: "Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors", NATURE COMMUNICATIONS, vol. 13, no. 1, XP093100641, DOI: 10.1038/s41467-022-29655-0
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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