Title:
ALDEHYDE GROUP COMPOUNDS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/223718
Kind Code:
A1
Abstract:
The present invention relates to the fields of pharmacochemistry and pharmacotherapy, and in particular relates to compounds of general formula I as 3CL protease inhibitors of SARS-CoV-2. At the same time, the compounds have significant inhibitory activity on other coronaviruses (SARS and MERS) and RNA virus proteases, and can be used for treating related diseases. The present invention also relates to a preparation method for such compounds, pharmaceutical compositions of these compounds, and pharmaceutically acceptable salts, enantiomeric forms, diastereomers and racemic compounds thereof.
Inventors:
LIU HONG (CN)
LI JIAN (CN)
XIE XIONG (CN)
DAI WENHAO (CN)
PENG JINGJING (CN)
HU SHULEI (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
LI JIAN (CN)
XIE XIONG (CN)
DAI WENHAO (CN)
PENG JINGJING (CN)
HU SHULEI (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2021/091951
Publication Date:
November 11, 2021
Filing Date:
May 06, 2021
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/4025; C07D401/14; A61K31/4155; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/4365; A61K31/437; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4725; A61K31/513; A61K31/519; A61P31/14; C07D207/27; C07D403/12; C07D405/14; C07D413/14; C07D471/04; C07D487/04; C07D495/04
Domestic Patent References:
| WO2013166319A1 | 2013-11-07 | |||
| WO2013049382A2 | 2013-04-04 |
Other References:
ZHANG LINLIN, LIN DAIZONG, SUN XINYUANYUAN, ROX KATHARINA, HILGENFELD ROLF: "Abstract", BIORXIV, 20 February 2020 (2020-02-20), XP055855123, DOI: 10.1101/2020.02.17.952879
DATABASE REGISTRY 16 September 2011 (2011-09-16), ANONYMOUS : " 1(2H)-Pyridineacetamide, .alpha.-[(3,4-difluorophenyl)methyl]-N-[(1R)-1- formyl-2-[(3R)-2-oxo-3-pyrrolidinyl]ethyl]-3-[[(5-methyl-3- isoxazolyl)carbonyl]amino]-2-oxo-, (.alpha.R)-rel- (CA INDEX NAME)", XP055864135, retrieved from STN Database accession no. 1332587-95-7
VISHNU C. DAMALANKA ET AL.: "Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 143, 6 December 2017 (2017-12-06), XP085306108, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.12.014
DATABASE REGISTRY 16 September 2011 (2011-09-16), ANONYMOUS : " 1(2H)-Pyridineacetamide, .alpha.-[(3,4-difluorophenyl)methyl]-N-[(1R)-1- formyl-2-[(3R)-2-oxo-3-pyrrolidinyl]ethyl]-3-[[(5-methyl-3- isoxazolyl)carbonyl]amino]-2-oxo-, (.alpha.R)-rel- (CA INDEX NAME)", XP055864135, retrieved from STN Database accession no. 1332587-95-7
VISHNU C. DAMALANKA ET AL.: "Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 143, 6 December 2017 (2017-12-06), XP085306108, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.12.014
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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