Title:
ALDH2 ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2019/151241
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt of the compound.
(In the formula, X and Y may be the same or different, and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, and the C1-6 alkoxy group may be substituted by a C1-6 alkoxy group; and Z and W may be the same or different, and each represents a hydrogen atom, a halogen atom or a C1-6 alkyl group.)
Inventors:
TANAKA KEIGO (JP)
ISHIDA TASUKU (JP)
MIYANO MASAYUKI (JP)
SHINKYO RAKU (JP)
ISHIDA TASUKU (JP)
MIYANO MASAYUKI (JP)
SHINKYO RAKU (JP)
Application Number:
PCT/JP2019/002955
Publication Date:
August 08, 2019
Filing Date:
January 29, 2019
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07C233/73; A61K31/166; A61P7/06; A61P17/02; A61P19/10; A61P29/00; A61P43/00; C07C235/60
Domestic Patent References:
| WO2014160185A2 | 2014-10-02 | |||
| WO2007139149A1 | 2007-12-06 |
Foreign References:
| JP2012087116A | 2012-05-10 | |||
| JP2016514154A | 2016-05-19 | |||
| JP2010523476A | 2010-07-15 |
Other References:
DATABASE Registry 19 September 2009 (2009-09-19), retrieved from STN Database accession no. 1181487-96-6
DATABASE REgistry 6 August 2012 (2012-08-06), retrieved from STN Database accession no. 1386951-84-3
DATABASE Registry 3 August 2012 (2012-08-03), retrieved from STN Database accession no. 1386285-41-1
QIANKUN ZHU ET AL.: "Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice", CLINICAL SCIENCE, vol. 131, 2017, pages 1123 - 1136
MONIKA MITTAL ET AL.: "Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect", TOXICOLOGY AND APPLIED PHARMACOLOGY., vol. 316, 2017, pages 63 - 73, XP029889375, DOI: 10.1016/j.taap.2016.12.013
F. PETER GUENGERICH: "Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development", DRUG METABOLISM AND PHARMACOKINETICS., vol. 26, 14 March 2011 (2011-03-14)
SHINTARO NAKAYAMA ET AL.: "A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding", DRUG METABOLISM AND DISPOSITION., vol. 37, 2009, pages 1970 - 1977
YOSHIHIRO MIYAJI ET AL.: "In vitro evaluation of the potential for drug-induced toxicity based on 35S-labeled glutathione adduct formation and daily dose", BIOANALYSIS., vol. 4, 2012, pages 263 - 269
J. MED. CHEM., vol. 34, no. 1, 1991, pages 227 - 234
J. MED. CHEM., vol. 37, no. 7, 1994, pages 999 - 1014
ORG. LETT., vol. 14, no. 11, 2012, pages 2818 - 2821
J. ORG. CHEM., vol. 42, no. 12, 1977, pages 2053 - 2058
J. MED. CHEM., vol. 47, no. 4, 2004, pages 871 - 887
J. MASS SPECTRUM. SOC. JPN., vol. 51, no. 5, 2003, pages 492 - 498
DATABASE REgistry 6 August 2012 (2012-08-06), retrieved from STN Database accession no. 1386951-84-3
DATABASE Registry 3 August 2012 (2012-08-03), retrieved from STN Database accession no. 1386285-41-1
QIANKUN ZHU ET AL.: "Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice", CLINICAL SCIENCE, vol. 131, 2017, pages 1123 - 1136
MONIKA MITTAL ET AL.: "Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect", TOXICOLOGY AND APPLIED PHARMACOLOGY., vol. 316, 2017, pages 63 - 73, XP029889375, DOI: 10.1016/j.taap.2016.12.013
F. PETER GUENGERICH: "Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development", DRUG METABOLISM AND PHARMACOKINETICS., vol. 26, 14 March 2011 (2011-03-14)
SHINTARO NAKAYAMA ET AL.: "A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding", DRUG METABOLISM AND DISPOSITION., vol. 37, 2009, pages 1970 - 1977
YOSHIHIRO MIYAJI ET AL.: "In vitro evaluation of the potential for drug-induced toxicity based on 35S-labeled glutathione adduct formation and daily dose", BIOANALYSIS., vol. 4, 2012, pages 263 - 269
J. MED. CHEM., vol. 34, no. 1, 1991, pages 227 - 234
J. MED. CHEM., vol. 37, no. 7, 1994, pages 999 - 1014
ORG. LETT., vol. 14, no. 11, 2012, pages 2818 - 2821
J. ORG. CHEM., vol. 42, no. 12, 1977, pages 2053 - 2058
J. MED. CHEM., vol. 47, no. 4, 2004, pages 871 - 887
J. MASS SPECTRUM. SOC. JPN., vol. 51, no. 5, 2003, pages 492 - 498
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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