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Title:
ALK2 KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/198114
Kind Code:
A1
Abstract:
An ALK2 kinase inhibitor as represented by general formula (I), a pharmaceutical composition thereof, a preparation method therefor, and use of the ALK2 kinase inhibitor in preparing a drug for the prevention and/or treatment of indications related to the ALK2 signaling pathway. A compound of the present invention is an ideal high-activity ALK2 kinase inhibitor, and can be used for treating and/or preventing diseases, including anemia, inflammation, tumors, and some rare diseases, such as fibrodysplasia ossificans progressiva, diffuse intrinsic pontine glioma, iron refractory iron deficiency anemia, inflammatory anemia, myelodysplastic syndrome, and multiple myeloma, and can also be combined with a JAK2 inhibitor to treat MPN-related anemia.

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Inventors:
YANG XIN (CN)
CUI RONG (CN)
WEN QIAODONG (CN)
YIN JIANMING (CN)
ZHENG MEI (CN)
LV YUBIN (CN)
Application Number:
PCT/CN2023/087857
Publication Date:
October 19, 2023
Filing Date:
April 12, 2023
Export Citation:
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Assignee:
HANGZHOU BANGSHUN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4439; C07D405/14; A61K31/496; A61K31/506; A61K31/519; A61K31/5377; A61P7/06; A61P29/00; A61P35/00; C07D213/82; C07D405/12; C07D413/14; C07D471/10; C07D487/04; C07D491/044; C07D491/048; C07D491/20
Domestic Patent References:
WO2019236631A12019-12-12
WO2018183633A12018-10-04
WO2022184152A12022-09-09
Foreign References:
CN109641871A2019-04-16
CN110913855A2020-03-24
CN111164083A2020-05-15
Other References:
AGUSTIN H MOHEDAS ET AL.: "Structure-Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants", J. MED. CHEM., vol. 57, no. 19, 7 August 2014 (2014-08-07), XP055227623, ISSN: 0022-2623, DOI: 10.1021/jm501177w
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