Title:
ALKYL HALIDE, ALKYLATING AGENT USING SAME, AND METHOD FOR PRODUCING DERIVATIVE OF NUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2024/024766
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an alkylating agent that can alkylate a hydroxyl group at 2' position of a synthetic intermediate for an amidite compound in the presence of a base. The present invention provides an alkyl halide that is represented by general formula (I) and can achieve alkylation in the presence of a base. [In the formula, X represents a halogen atom, n represents an integer of 1-5, R1 and R2 are the same or different and represent a methyl group, an ethyl group, or a hydrogen atom, and EWG represents a cyano group or SO2R3 group (R3 represents a phenyl group, a C1-10 alkyl group, or a benzyl group which are optionally substituted with a halogen atom, a methyl group, a nitro group, a methoxy group, or a trifluoromethyl group).]
Inventors:
KOSHIMOTO KYOHEI (JP)
Application Number:
PCT/JP2023/027116
Publication Date:
February 01, 2024
Filing Date:
July 25, 2023
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07C255/13; C07H19/067
Domestic Patent References:
| WO2019208571A1 | 2019-10-31 | |||
| WO2021079617A1 | 2021-04-29 | |||
| WO2013027843A1 | 2013-02-28 |
Other References:
PAV, O. ET AL.: "Synthesis of oligoribonucleotides with phosphonate-modified linkages", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, no. 17, 2011, pages 6120 - 6126, XP055535662, DOI: 10.1039/c1ob05488k
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