ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY

Title:

ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY

Document Type and Number:

WIPO Patent Application WO2005122379

Kind Code:

A9

Abstract:

The present invention provides a 4ß1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural amino acid or a D-amino acid, and wherein n is an integer of from 3 to 20. Methods are provided for administering the ligands for treating cancer, inflammatory diseases, and autoimmune diseases. Also provided are methods for administering the ligands for imaging a tumor, organ, or tissue in a subject.

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Inventors:

LAM KIT S (US)
LIU RUIWU (US)
PENG LI (US)

Application Number:

PCT/US2005/018730

Publication Date:

March 09, 2006

Filing Date:

May 26, 2005

Export Citation:

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Assignee:

UNIV CALIFORNIA (US)
LAM KIT S (US)
LIU RUIWU (US)
PENG LI (US)

International Classes:

A61K45/06; C07C275/42; C07K5/02; C07K7/02; H02N1/00; (IPC1-7): H02N1/00

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