Title:
ALPROSTADIL LIPID EMULSION FOR INJECTION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2015/165373
Kind Code:
A1
Abstract:
An alprostadil lipid emulsion for injection and a preparation method therefor. The lipid emulsion contains alprostadil, phosphatidylcholine, phosphatidylglycerol, oil for injection and a lyophilized protective agent. Based on 1 part by weight of the alprostadil, the content of the phosphatidylcholine is 1200 to 4000 parts by weight, the content of the phosphatidylglycerol is 12 to 120 parts by weight, the content of the oil for injection is 2000 to 20000 parts by weight, and the content of the lyophilized protective agent is 16000 to 60000 parts by weight.
Inventors:
LIN JINPING (CN)
SONG HUAXIAN (CN)
SONG HUAXIAN (CN)
Application Number:
PCT/CN2015/077642
Publication Date:
November 05, 2015
Filing Date:
April 28, 2015
Export Citation:
Assignee:
BEIJING LANDAN PHARMACEUTICAL TECHNOLOGY CO LTD (CN)
International Classes:
A61K9/19; A61K9/107; A61K31/5575; A61K47/24; A61P9/00
Domestic Patent References:
| WO2000016744A1 | 2000-03-30 |
Foreign References:
| CN101511367A | 2009-08-19 | |||
| CN103301076A | 2013-09-18 | |||
| CN103655487A | 2014-03-26 |
Other References:
NONGNUCH PONGCHAROENKIAT ET AL.: "The effect of Surface Charge and Partition Coefficient on the Chemical Stability of Solutes in O/W Emulsions", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, no. 2, 28 February 2002 (2002-02-28), XP055232185, ISSN: 0022-3549
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
北京润平知识产权代理有限公司 (CN)
北京润平知识产权代理有限公司 (CN)
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