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Title:
AMIDE ANTIVIRAL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/134730
Kind Code:
A1
Abstract:
The present invention provides a pyrrolidine compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and a use thereof as a coronavirus 3CL protease inhibitor in the prevention or treatment of related diseases caused by coronavirus infection.

Inventors:
ZOU HAO (CN)
ZHU WEI (CN)
ZHU DONGXING (CN)
JIN JINGHAI (CN)
LIU LANG (CN)
WANG WEIKUN (CN)
XU SHUN (CN)
LI ZHENGTAO (CN)
Application Number:
PCT/CN2023/071925
Publication Date:
July 20, 2023
Filing Date:
January 12, 2023
Export Citation:
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Assignee:
SIMCERE ZAIMING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K5/062; A61K38/05; A61K45/06; A61P31/14; C07D207/26; C07D209/52; C07D401/12; C07D403/12
Domestic Patent References:
WO2021250648A12021-12-16
WO2021252644A12021-12-16
WO2022020242A12022-01-27
WO2022020711A12022-01-27
WO2022251615A12022-12-01
WO2022256434A12022-12-08
Foreign References:
CN114149415A2022-03-08
CN114426568A2022-05-03
Other References:
BETHANY, HALFORD: "Pfizer unveils its oral SARS-CoV-2 inhibitor", CHEMICAL & ENGINEERING NEWS, vol. 99, no. 13, 12 April 2021 (2021-04-12), XP055976884
ALUGUBELLI, YUGENDAR R. ET AL.: "A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 240, 8 July 2022 (2022-07-08), XP087144478, DOI: 10.1016/j.ejmech.2022.114596
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