Title:
AMIDE ANTIVIRAL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/134730
Kind Code:
A1
Abstract:
The present invention provides a pyrrolidine compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and a use thereof as a coronavirus 3CL protease inhibitor in the prevention or treatment of related diseases caused by coronavirus infection.
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Inventors:
ZOU HAO (CN)
ZHU WEI (CN)
ZHU DONGXING (CN)
JIN JINGHAI (CN)
LIU LANG (CN)
WANG WEIKUN (CN)
XU SHUN (CN)
LI ZHENGTAO (CN)
ZHU WEI (CN)
ZHU DONGXING (CN)
JIN JINGHAI (CN)
LIU LANG (CN)
WANG WEIKUN (CN)
XU SHUN (CN)
LI ZHENGTAO (CN)
Application Number:
PCT/CN2023/071925
Publication Date:
July 20, 2023
Filing Date:
January 12, 2023
Export Citation:
Assignee:
SIMCERE ZAIMING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K5/062; A61K38/05; A61K45/06; A61P31/14; C07D207/26; C07D209/52; C07D401/12; C07D403/12
Domestic Patent References:
WO2021250648A1 | 2021-12-16 | |||
WO2021252644A1 | 2021-12-16 | |||
WO2022020242A1 | 2022-01-27 | |||
WO2022020711A1 | 2022-01-27 | |||
WO2022251615A1 | 2022-12-01 | |||
WO2022256434A1 | 2022-12-08 |
Foreign References:
CN114149415A | 2022-03-08 | |||
CN114426568A | 2022-05-03 |
Other References:
BETHANY, HALFORD: "Pfizer unveils its oral SARS-CoV-2 inhibitor", CHEMICAL & ENGINEERING NEWS, vol. 99, no. 13, 12 April 2021 (2021-04-12), XP055976884
ALUGUBELLI, YUGENDAR R. ET AL.: "A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 240, 8 July 2022 (2022-07-08), XP087144478, DOI: 10.1016/j.ejmech.2022.114596
ALUGUBELLI, YUGENDAR R. ET AL.: "A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 240, 8 July 2022 (2022-07-08), XP087144478, DOI: 10.1016/j.ejmech.2022.114596
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